scholarly journals Lead aggravates the diabetic-induced reproductive toxicity in male Wistar rats

2016 ◽  
Vol 5 (5) ◽  
pp. 1465-1476 ◽  
Author(s):  
K. Pratap Reddy ◽  
Madamsetti Narayana Rao ◽  
J. S. R. Murthy ◽  
P. Sreenivasula Reddy
Keyword(s):  
Metabolic Disorder ◽  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Lead Contamination ◽  
Contemporary Society ◽  
Male Wistar Rats

Diabetes, an unresolved metabolic disorder, and lead contamination are prevalent problems in contemporary society.

Cocos nucifera L. oil alleviates lead acetate-induced reproductive toxicity in sexually-matured male Wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Olugbemi T. Olaniyan ◽  
Olakunle A. Ojewale ◽  
Ayobami Dare ◽  
Olufemi Adebayo ◽  
Joseph E. Enyojo ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Histological Analysis ◽  
Cocos Nucifera ◽  
Reproductive Toxicity ◽  
Positive Control ◽  
Negative Control ◽  
Male Wistar Rats ◽  
Cocos Nucifera L

Abstract Objectives Lead primarily affects male reproductive functions via hormonal imbalance and morphological damage to the testicular tissue with significant alteration in sperm profile and oxidative markers. Though, different studies have reported that Cocos nucifera L. oil has a wide range of biological effects, this study aimed at investigating the effect of Cocos nucifera L. oil on lead acetate-induced reproductive toxicity in male Wistar rats. Methods Twenty (20) sexually matured male Wistar rats (55–65 days) were randomly distributed into four groups (n=5). Group I (negative control)—distilled water orally for 56 days, Group II (positive control)—5 mg/kg bwt lead acetate intraperitoneally (i.p.) for 14 days, Group III—6.7 mL/kg bwt Cocos nucifera L. oil orally for 56 days and Group IV—lead acetate intraperitoneally (i.p.) for 14 days and Cocos nucifera L. oil for orally for 56 days. Rats were sacrificed by diethyl ether, after which the serum, testis and epididymis were collected and used for semen analysis, biochemical and histological analysis. Results The lead acetate significantly increases (p<0.05) testicular and epididymal malondialdehyde (MDA) levels, while a significant reduction (p<0.05) in sperm parameters, organ weight, testosterone and luteinizing hormone was observed when compared with the negative control. The coadministration of Cocos nucifera oil with lead acetate significantly increases (p<0.05) testosterone, luteinizing hormone, sperm parameters and organ weight, with a significant decrease (p<0.05) in MDA levels compared with positive control. Histological analysis showed that lead acetate distorts testicular cytoarchitecture and germ cell integrity while this was normalized in the cotreated group. Conclusions Cocos nucifera oil attenuates the deleterious effects of lead acetate in male Wistar rats, which could be attributed to its polyphenol content and antioxidant properties.

Cyclophosphamide-induced reproductive toxicity: Beneficial effects of Helichrysum odoratissimum (Asteraceae) in male Wistar rats

2019 ◽  
Vol 17 (5) ◽  
pp. 366-373 ◽  
Author(s):  
Pierre Watcho ◽  
Ismaelle Rosine Mpeck ◽  
Patrick Brice Deeh Defo ◽  
Modeste Wankeu-Nya ◽  
Esther Ngadjui ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Beneficial Effects ◽  
Male Wistar Rats

scholarly journals Protective effects of Camellia sinensis on Syzygium aromaticum- or chlorpyrifos-induced reproductive toxicity in male Wistar rats

2019 ◽  
Vol 80 (1) ◽  
Author(s):  
Damola V. Akinwande ◽  
Joseph A. Adeyemi ◽  
Solomon T. Olawuyi ◽  
Busuyi K. Akinola ◽  
Chris O. Adedire
Keyword(s):  
Camellia Sinensis ◽  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Syzygium Aromaticum ◽  
Protective Effects ◽  
Male Wistar Rats

scholarly journals Clomiphene citrate ameliorated lead acetate-induced reproductive toxicity in male Wistar rats

2019 ◽  
Author(s):  
Oyeyemi A.Wahab ◽  
Anyanwu C. Princely ◽  
Akinola A. Oluwadamilare ◽  
Daramola O. Oore-oluwapo ◽  
Alli O. Blessing ◽  
...  
Keyword(s):  
Lead Acetate ◽  
Wistar Rats ◽  
Clomiphene Citrate ◽  
Reproductive Toxicity ◽  
Male Wistar Rats

scholarly journals Protective role of N-Acetyl L-Cysteine against reproductive toxicity due to interaction of lead and cadmium in male Wistar rats

2013 ◽  
Vol 4 (2) ◽  
pp. 414 ◽  
Author(s):  
AllaGopala Reddy ◽  
PentelaRavi Kumar ◽  
YerradoddiRamana Reddy ◽  
ThirthamMadava Rao ◽  
Chiluka Haritha ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Protective Role ◽  
Lead And Cadmium ◽  
Male Wistar Rats

Reproductive toxicity of lapachol in adult male Wistar rats submitted to short-term treatment

2007 ◽  
Vol 21 (7) ◽  
pp. 658-662 ◽  
Author(s):  
Rita de Cássia da Silveira e Sá ◽  
Martha de Oliveira Guerra
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment ◽  
Male Wistar Rats

scholarly journals Protective effect of vitamin C on chronic carbamazepine-induced reproductive toxicity in male wistar rats

2020 ◽  
Vol 7 ◽  
pp. 269-276 ◽  
Author(s):  
Ganiu Jimoh Akorede ◽  
Suleiman Folorusho Ambali ◽  
Mikai’l Garba Hudu ◽  
Aisha Omobolanle Olatunji ◽  
Muftau Shittu ◽  
...  
Keyword(s):  
Vitamin C ◽  
Protective Effect ◽  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Male Wistar Rats
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