Reproductive toxicity of lapachol in adult male Wistar rats submitted to short-term treatment

2007 ◽  
Vol 21 (7) ◽  
pp. 658-662 ◽  
Author(s):  
Rita de Cássia da Silveira e Sá ◽  
Martha de Oliveira Guerra
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment ◽  
Male Wistar Rats

scholarly journals Short-term menthol treatment promotes persistent thermogenesis without induction of compensatory food consumption in Wistar rats: implications for obesity control

2018 ◽  
Vol 124 (3) ◽  
pp. 672-683 ◽  
Author(s):  
Robson Cristiano Lillo Vizin ◽  
Anna Carolina P. Motzko-Soares ◽  
Giovana Marchini Armentano ◽  
Débora T. Ishikawa ◽  
Ariovaldo P. Cruz-Neto ◽  
...  
Keyword(s):  
Food Intake ◽  
Energy Expenditure ◽  
Body Mass ◽  
Wistar Rats ◽  
Transient Receptor Potential ◽  
Mass Gain ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment ◽  
Cutaneous Vasoconstriction

In this study, we aimed to evaluate the influence of daily repeated menthol treatments on body mass and thermoregulatory effectors in Wistar rats, considering that menthol is a transient receptor potential melastatin 8 channel agonist that mimics cold sensation and activates thermoregulatory cold-defense mechanisms in mammals, promoting hyperthermia and increasing energy expenditure, and has been suggested as an anti-obesity drug. Male Wistar rats were topically treated with 5% menthol for 3 or 9 consecutive days while body mass, food intake, abdominal temperature, metabolism, cutaneous vasoconstriction, and thermal preference were measured. Menthol promoted hyperthermia on all days of treatment, due to an increase in metabolism and cutaneous vasoconstriction, without affecting food intake, resulting in less mass gain in menthol-hyperthermic animals. As the treatment progressed, the menthol-induced increases in metabolism and hyperthermia were attenuated but not abolished. Moreover, cutaneous vasoconstriction was potentiated, and an increase in the warmth-seeking behavior was induced. Taken together, the results suggest that, although changes occur in thermoeffector recruitment during the course of short-term treatment, menthol is a promising drug to prevent body mass gain. NEW & NOTEWORTHY Menthol produces a persistent increase in energy expenditure, with limited compensatory thermoregulatory adaptations and, most unexpectedly, without affecting food intake. Thus short-term treatment with menthol results in less mass gain in treated animals compared with controls. Our results suggest that menthol is a promising drug for the prevention of obesity.

scholarly journals Effects of Short-Term Treatment with Estrogen Receptor Agonist on Morphological Changes in Reproductive Organs of Adult Male Mice

2016 ◽  
Vol 46 (4) ◽  
pp. 193-200
Author(s):  
Hayana Choi ◽  
Yun Jeong Mo ◽  
Mi-Kyung Lee ◽  
Eun Sang Choe ◽  
Sung Tae Yee ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Adult Male ◽  
Receptor Agonist ◽  
Morphological Changes ◽  
Reproductive Organs ◽  
Term Treatment ◽  
Male Mice ◽  
Short Term ◽  
Short Term Treatment

scholarly journals Short-Term Treatment with Bisphenol-A Leads to Metabolic Abnormalities in Adult Male Mice

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e33814 ◽  
Author(s):  
Thiago M. Batista ◽  
Paloma Alonso-Magdalena ◽  
Elaine Vieira ◽  
Maria Esmeria C. Amaral ◽  
Christopher R. Cederroth ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Adult Male ◽  
Term Treatment ◽  
Metabolic Abnormalities ◽  
Male Mice ◽  
Short Term ◽  
Short Term Treatment

Adrenal phenotype in TPIT insufficient animals cannot be restored by short-term treatment with physiological doses of ACTH and N-POMC

2005 ◽  
Vol 113 (S 1) ◽  
Author(s):  
S Klammer ◽  
D Schulte ◽  
M Fassnacht ◽  
S Hahner ◽  
AM Pulichino ◽  
...  
Keyword(s):  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment

Cocos nucifera L. oil alleviates lead acetate-induced reproductive toxicity in sexually-matured male Wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Olugbemi T. Olaniyan ◽  
Olakunle A. Ojewale ◽  
Ayobami Dare ◽  
Olufemi Adebayo ◽  
Joseph E. Enyojo ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Histological Analysis ◽  
Cocos Nucifera ◽  
Reproductive Toxicity ◽  
Positive Control ◽  
Negative Control ◽  
Male Wistar Rats ◽  
Cocos Nucifera L

Abstract Objectives Lead primarily affects male reproductive functions via hormonal imbalance and morphological damage to the testicular tissue with significant alteration in sperm profile and oxidative markers. Though, different studies have reported that Cocos nucifera L. oil has a wide range of biological effects, this study aimed at investigating the effect of Cocos nucifera L. oil on lead acetate-induced reproductive toxicity in male Wistar rats. Methods Twenty (20) sexually matured male Wistar rats (55–65 days) were randomly distributed into four groups (n=5). Group I (negative control)—distilled water orally for 56 days, Group II (positive control)—5 mg/kg bwt lead acetate intraperitoneally (i.p.) for 14 days, Group III—6.7 mL/kg bwt Cocos nucifera L. oil orally for 56 days and Group IV—lead acetate intraperitoneally (i.p.) for 14 days and Cocos nucifera L. oil for orally for 56 days. Rats were sacrificed by diethyl ether, after which the serum, testis and epididymis were collected and used for semen analysis, biochemical and histological analysis. Results The lead acetate significantly increases (p<0.05) testicular and epididymal malondialdehyde (MDA) levels, while a significant reduction (p<0.05) in sperm parameters, organ weight, testosterone and luteinizing hormone was observed when compared with the negative control. The coadministration of Cocos nucifera oil with lead acetate significantly increases (p<0.05) testosterone, luteinizing hormone, sperm parameters and organ weight, with a significant decrease (p<0.05) in MDA levels compared with positive control. Histological analysis showed that lead acetate distorts testicular cytoarchitecture and germ cell integrity while this was normalized in the cotreated group. Conclusions Cocos nucifera oil attenuates the deleterious effects of lead acetate in male Wistar rats, which could be attributed to its polyphenol content and antioxidant properties.

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