pH-Responsive near-infrared fluorescent cyanine dyes for molecular imaging based on pH sensing

2017 ◽  
Vol 53 (55) ◽  
pp. 7792-7795 ◽  
Author(s):  
Koji Miki ◽  
Kentaro Kojima ◽  
Kazuaki Oride ◽  
Hiroshi Harada ◽  
Akiyo Morinibu ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Near Infrared ◽  
Cyanine Dyes ◽  
Living Cells ◽  
Ph Sensing ◽  
Ph Responsive ◽  
Imaging Probes ◽  
Intracellular Compartments

pH-Responsive near-infrared cyanine dyes were synthesized and applied as imaging probes of acidic intracellular compartments of living cells.

A naked-eye and ratiometric near-infrared probe for palladium via modulation of a π-conjugated system of cyanines

2014 ◽  
Vol 50 (88) ◽  
pp. 13525-13528 ◽  
Author(s):  
Xiaohang Wang ◽  
Zhiqian Guo ◽  
Shiqin Zhu ◽  
He Tian ◽  
Weihong Zhu
Keyword(s):  
Near Infrared ◽  
Stokes Shift ◽  
Cyanine Dyes ◽  
Living Cells ◽  
Aqueous Samples ◽  
Ratiometric Fluorescence ◽  
Large Stokes Shift ◽  
Naked Eye ◽  
Fluorescence Change

The modulation of π-conjugated electrons in cyanine dyes can result in a ratiometric fluorescence change with a large Stokes shift (270 nm), especially for realizing palladium detection in aqueous samples using indicator paper and in living cells by ratiometric mode.

IMAGING RNA IN LIVING CELLS WITH MOLECULAR BEACONS: CURRENT PERSPECTIVES AND CHALLENGES

2009 ◽  
Vol 02 (04) ◽  
pp. 315-324 ◽  
Author(s):  
ANTONY K. CHEN ◽  
ANDREW TSOURKAS
Keyword(s):  
Gene Expression ◽  
Molecular Imaging ◽  
Cell Fate ◽  
Dna Microarrays ◽  
Living Cells ◽  
Molecular Beacons ◽  
Rna Molecules ◽  
Molecular Imaging Probes ◽  
Imaging Probes ◽  
Phenotype Diversity

There is a growing realization that cell-to-cell variations in gene expression have important biological consequences underlying phenotype diversity and cell fate. Although analytical tools for measuring gene expression, such as DNA microarrays, reverse-transcriptase PCR and in situ hybridization have been widely utilized to discover the role of genetic variations in governing cellular behavior, these methods are performed in cell lysates and/or on fixed cells, and therefore lack the ability to provide comprehensive spatial-dynamic information on gene expression. This has invoked the recent development of molecular imaging strategies capable of illuminating the distribution and dynamics of RNA molecules in living cells. In this review, we describe a class of molecular imaging probes known as molecular beacons (MBs), which have increasingly become the probe of choice for imaging RNA in living cells. In addition, we present the major challenges that can limit the ability of MBs to provide accurate measurements of RNA, and discuss efforts that have been made to overcome these challenges. It is envisioned that with continued refinement of the MB design, MBs will eventually become an indispensable tool for analyzing gene expression in biology and medicine.

Examination of Chlorin-Bacteriochlorin Energy-transfer Dyads as Prototypes for Near-infrared Molecular Imaging Probes†

2008 ◽  
Vol 84 (5) ◽  
pp. 1061-1072 ◽  
Author(s):  
Hooi Ling Kee ◽  
Ralph Nothdurft ◽  
Chinnasamy Muthiah ◽  
James R. Diers ◽  
Dazhong Fan ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Molecular Imaging ◽  
Near Infrared ◽  
Molecular Imaging Probes ◽  
Imaging Probes

Degradable pH-responsive NIR-II imaging probes based on a polymer-lanthanide composite for chemotherapy

2020 ◽  
Vol 49 (27) ◽  
pp. 9444-9453
Author(s):  
Miao Feng ◽  
Yanxing Wang ◽  
Bi Lin ◽  
Xiangrong Peng ◽  
Ying Yuan ◽  
...  
Keyword(s):  
Rare Earth ◽  
Near Infrared ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Imaging Probes ◽  
Rare Earth Nanoparticles

A pH-sensitive nanoprobe was proposed by combining hydrophobic rare earth nanoparticles with biocompatible nanomicelles for near infrared-II (NIR-II) imaging-guided chemotherapy.

Azide Conjugatable and pH Responsive Near-Infrared Fluorescent Imaging Probes

2009 ◽  
Vol 11 (23) ◽  
pp. 5386-5389 ◽  
Author(s):  
Julie Murtagh ◽  
Daniel O. Frimannsson ◽  
Donal F. O’Shea
Keyword(s):  
Near Infrared ◽  
Fluorescent Imaging ◽  
Ph Responsive ◽  
Imaging Probes
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