Importance of protein flexibility on molecular recognition: modeling binding mechanisms of aminopyrazine inhibitors to Nek2
2018 ◽
Vol 20
(8)
◽
pp. 5591-5605
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Keyword(s):
NIMA-related kinase 2 (Nek2) plays a significant role in cell cycle regulation, and overexpression of Nek2 has been observed in several types of carcinoma, suggesting it is a potential target for cancer therapy. Computational methods were employed for deep understanding the interaction between Nek2 and inhibitors for future inhibitor design.
Keyword(s):
2020 ◽
2008 ◽
Vol 40
(9)
◽
pp. 1753-1763
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Keyword(s):
Keyword(s):
Keyword(s):
2013 ◽
Vol 138
(2)
◽
pp. 255-271
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Keyword(s):