Exploring the role of GS–GOGAT cycle in microcystin synthesis and regulation – a model based analysis

2017 ◽  
Vol 13 (12) ◽  
pp. 2603-2614 ◽  
Author(s):  
Swarnendu Banerjee ◽  
Abhishek Subramanian ◽  
Joydev Chattopadhyay ◽  
Ram Rup Sarkar
Keyword(s):  
Kinetic Model ◽  
Model Based ◽  
Gene Regulatory ◽  
Model Based Analysis

First kinetic model of microcystin regulation that explains the biochemical and gene regulatory events linking environmental nitrogen change with microcystin.

Model-based analysis of coupled equilibrium-kinetic processes: indirect kinetic studies of thermodynamic parameters using the dynamic data

The Analyst ◽  
2015 ◽  
Vol 140 (9) ◽  
pp. 3121-3135
Author(s):  
Fereshteh Emami ◽  
Marcel Maeder ◽  
Hamid Abdollahi
Keyword(s):  
Kinetic Model ◽  
Thermodynamic Parameters ◽  
Kinetic Models ◽  
Kinetic Studies ◽  
Dynamic Data ◽  
Model Based ◽  
Kinetic Processes ◽  
Model Based Analysis

Schematic of intertwined equilibrium-kinetic model at time = 0,1,2…T when both equilibrium and kinetic models are solved explicitly.

Model-Based Analysis of Friction-Induced Sub-Synchronous Whirl for a Rotor Contacting With Clearance Bearings Under Axial Load

2015 ◽  
Author(s):  
Matthew O. T. Cole ◽  
Lawrence Hawkins
Keyword(s):  
Axial Load ◽  
Coulomb Friction ◽  
Friction Forces ◽  
Root Finding ◽  
Model Based ◽  
Simple Physical Interpretation ◽  
Level Of Agreement ◽  
Model Based Analysis

For rotors supported by active magnetic bearings (AMBs), clearance bearings are commonly used to provide backup support under loss of AMB functionality. Test data from real machines shows that rotor vibration during touchdown on backup bearings may involve steady forward whirling at a sub-synchronous frequency. This excitation is believed to be due to friction forces transmitted between the rotor and a bearing end-face under axial load. This paper proposes a new analytical approach to model and predict such friction-driven forward whirl behaviors. A set of constraint equations are derived that relate a circular whirl motion of arbitrary orbital speed to the frequency response functions of the rotor-housing structure. This model is coupled with an evaluation of Coulomb friction associated with slip between the rotor and the supporting end-face of a thrust bearing. The resulting equations can be used to compute a set of possible whirl motions via a root-finding procedure. A case study is undertaken for a 140 kW energy storage flywheel. Model-based predictions are compared with measured data from spin-down tests and show a good level of agreement. The study confirms the role of friction-related forces in driving forward-whirl response behaviors. It also highlights the key role of housing and machine support characteristics in response behavior. This influence is shown to be complex and not open to simple physical interpretation. Therefore, the proposed analytical method is seen as a useful tool to investigate this influence while avoiding the need for time consuming numerical simulations.

Model-Based Analysis of Friction-Induced Subsynchronous Whirl for a Rotor Contacting With Clearance Bearings Under Axial Load

2016 ◽  
Vol 138 (7) ◽  
Author(s):  
Matthew O. T. Cole ◽  
Lawrence Hawkins
Keyword(s):  
Axial Load ◽  
Coulomb Friction ◽  
Friction Forces ◽  
Root Finding ◽  
Model Based ◽  
Simple Physical Interpretation ◽  
Level Of Agreement ◽  
Model Based Analysis

For rotors supported by active magnetic bearings (AMBs), clearance bearings are commonly used to provide backup support under loss of AMB functionality. Test data from real machines shows that vibration during touchdown on backup bearings may involve steady forward whirling of the rotor with a subsynchronous frequency. This excitation is believed to be due to friction forces transmitted between the rotor and a bearing end-face under axial load. This paper proposes a new analytical approach to model and predict such friction-driven forward whirl behaviors. A set of constraint equations are derived that relate a circular whirl motion of arbitrary orbital speed to the frequency response functions for the rotor-housing structure. This model is coupled with an evaluation of Coulomb friction associated with slip between the rotor and the supporting end-face of a thrust bearing. The resulting equations can be used to compute a set of possible whirl motions via a root-finding procedure. A case study is undertaken for a 140 kW energy storage flywheel. Model-based predictions are compared with measured data from spin-down tests and show a good level of agreement. The study confirms the role of friction-related forces in driving forward-whirl response behaviors. It also highlights the key role of housing and machine support characteristics in response behavior. This influence is shown to be complex and not open to simple physical interpretation. Therefore, the proposed analytical method is seen as a useful tool to investigate this influence while avoiding the need for time consuming numerical simulations.

scholarly journals Tight glycemic control in critical care – The leading role of insulin sensitivity and patient variability: A review and model-based analysis

2011 ◽  
Vol 102 (2) ◽  
pp. 156-171 ◽  
Author(s):  
J. Geoffrey Chase ◽  
Aaron J. Le Compte ◽  
Fatanah Suhaimi ◽  
Geoffrey M. Shaw ◽  
Adrienne Lynn ◽  
...  
Keyword(s):  
Critical Care ◽  
Insulin Sensitivity ◽  
Glycemic Control ◽  
Tight Glycemic Control ◽  
Model Based ◽  
Leading Role ◽  
Model Based Analysis

How do histone modifications contribute to transgenerational epigenetic inheritance in C. elegans?

2020 ◽  
Vol 48 (3) ◽  
pp. 1019-1034 ◽  
Author(s):  
Rachel M. Woodhouse ◽  
Alyson Ashe
Keyword(s):  
Histone Modifications ◽  
Molecular Mechanisms ◽  
Epigenetic Inheritance ◽  
Nematode Caenorhabditis Elegans ◽  
Histone Methyltransferases ◽  
Transgenerational Epigenetic Inheritance ◽  
C Elegans ◽  
Recent Developments ◽  
Gene Regulatory

Gene regulatory information can be inherited between generations in a phenomenon termed transgenerational epigenetic inheritance (TEI). While examples of TEI in many animals accumulate, the nematode Caenorhabditis elegans has proven particularly useful in investigating the underlying molecular mechanisms of this phenomenon. In C. elegans and other animals, the modification of histone proteins has emerged as a potential carrier and effector of transgenerational epigenetic information. In this review, we explore the contribution of histone modifications to TEI in C. elegans. We describe the role of repressive histone marks, histone methyltransferases, and associated chromatin factors in heritable gene silencing, and discuss recent developments and unanswered questions in how these factors integrate with other known TEI mechanisms. We also review the transgenerational effects of the manipulation of histone modifications on germline health and longevity.

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