Catechol- and ketone-containing multifunctional bottlebrush polymers for oxime ligation and hydrogel formation

2017 ◽  
Vol 8 (32) ◽  
pp. 4707-4715 ◽  
Author(s):  
Rimantas Slegeris ◽  
Brian A. Ondrusek ◽  
Hoyong Chung
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Poly Ethylene Glycol ◽  
Ring Opening Metathesis Polymerization ◽  
Metathesis Polymerization ◽  
Hydrogel Formation ◽  
Poly Ethylene

We report the synthesis of a highly-functional macromonomer, and subsequent crosslinkable poly(ethylene glycol) (PEG)-based bottlebrush polymers prepared via graft-through ring-opening metathesis polymerization (ROMP).

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis, Non-Acylating Performance and In Vivo Degradation

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1438
Author(s):  
Silvio Curia ◽  
Feifei Ng ◽  
Marie-Emérentienne Cagnon ◽  
Victor Nicoulin ◽  
Adolfo Lopez-Noriega
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Gel Chromatography ◽  
Amphiphilic Copolymers ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Acting ◽  
In Vivo Degradation

This article presents the evaluation of diblock and triblock poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-opening polymerisation. The concomitant formation of PTMC homopolymer could not be avoided irrespective of the catalyst amount, but the by-product could easily be removed by gel chromatography. Pure PEG-PTMCs undergo faster erosion in vivo than their corresponding homopolymer. Furthermore, these copolymers show outstanding stability compared to their polyester analogues when formulated with amine-containing reactive drugs, which makes them particularly suitable as LAIs for the sustained release of drugs susceptible to acylation.

scholarly journals Poly(ethylene) glycol hydrogel based on oxa-Michael reaction: Precursor synthesis and hydrogel formation

2017 ◽  
Vol 12 (2) ◽  
pp. 02C414 ◽  
Author(s):  
Hanqi Wang ◽  
Fang Cheng ◽  
Wei He ◽  
Jiaohui Zhu ◽  
Gang Cheng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Michael Reaction ◽  
Poly Ethylene Glycol ◽  
Precursor Synthesis ◽  
Hydrogel Formation ◽  
Poly Ethylene

Dual mode gelation behavior of silk fibroin microgel embedded poly(ethylene glycol) hydrogels

2016 ◽  
Vol 4 (26) ◽  
pp. 4574-4584 ◽  
Author(s):  
S. Ryu ◽  
H. H. Kim ◽  
Y. H. Park ◽  
C.-C. Lin ◽  
I. C. Um ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Silk Fibroin ◽  
Cross Linking ◽  
Poly Ethylene Glycol ◽  
Dual Mode ◽  
Hydrogel Formation ◽  
Gelation Behavior ◽  
Poly Ethylene

Hydrogel formation by more than two cross-linking mechanisms is preferred for the sophisticated manipulation of hydrogel properties.

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