A poly(ε-caprolactone)–poly(glycerol)–poly(ε-caprolactone) triblock copolymer for designing a polymeric micelle as a tumor targeted magnetic resonance imaging contrast agent

2017 ◽  
Vol 5 (42) ◽  
pp. 8408-8416 ◽  
Author(s):  
Yi Cao ◽  
Min Liu ◽  
Ye Kuang ◽  
Guangyue Zu ◽  
Dangsheng Xiong ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Triblock Copolymer ◽  
Polymeric Micelle ◽  
Resonance Imaging ◽  
High Relaxivity ◽  
Magnetic Resonance Imaging Contrast ◽  
Magnetic Resonance Imaging Mri ◽  
Imaging Contrast Agent

Gadolinium-based macromolecular contrast agents (CAs) with favorable biocompatibility, targeting specificity, and high relaxivity properties are desired for magnetic resonance imaging (MRI) of tumors.

A High Relaxivity Magnetic Resonance Imaging Contrast Agent Targeted to Serum Albumin

2008 ◽  
Vol 61 (9) ◽  
pp. 682 ◽  
Author(s):  
Stéphane Dumas ◽  
Jeffrey S. Troughton ◽  
Normand J. Cloutier ◽  
Jaclyn M. Chasse ◽  
Thomas J. McMurry ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Serum Albumin ◽  
Contrast Agent ◽  
Binding Sites ◽  
Resonance Imaging ◽  
High Relaxivity ◽  
Magnetic Resonance Imaging Contrast ◽  
Magnetic Resonance Angiographic ◽  
Imaging Contrast Agent

EP-647 is a serum albumin-targeted magnetic resonance imaging contrast agent comprising a GdDTPA (DTPA, diethylenetriaminepentaacetate) chelate for magnetic resonance signal generation linked via a phosphodiester to a substituted biphenyl for albumin targeting. Albumin binding and relaxivity are higher than the benchmark magnetic resonance angiographic agent MS-325. EP-647 binds primarily to a unique site on serum albumin that is different from the MS-325 site and the binding sites of other drugs.

Gadolinium complexes of macrocyclic diethylenetriamine-N-oxide pentaacetic acid-bisamide as highly stable MRI contrast agents with high relaxivity

2020 ◽  
Vol 49 (26) ◽  
pp. 8927-8932
Author(s):  
Kehan Xu ◽  
Na Xu ◽  
Beibei Zhang ◽  
Weijun Tang ◽  
Yun Ding ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Gadolinium Complexes ◽  
High Relaxivity ◽  
Magnetic Resonance Imaging Mri

Macrocyclic gadolinium(iii) complexes with hyphenated-amino-N-oxide (HAO) type ligand structures are designed as efficient magnetic resonance imaging (MRI) contrast agents (CAs) with high relaxivity and stability.

The Application Of Molecular Sieves As Magnetic Resonance Imaging Contrast Agents

1991 ◽  
Vol 233 ◽  
Author(s):  
Kenneth J. Balkus ◽  
Iwona Bresinska ◽  
Stanislaw Kowalak ◽  
Stuart W. Young
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Molecular Sieves ◽  
Mri Contrast Agents ◽  
Paramagnetic Species ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Contrast ◽  
Magnetic Resonance Imaging Mri

ABSTRACTThe application of zeolite molecular sieves as Magnetic Resonance Imaging (MRI) contrast agents is presented. Recent progress is described for X, Y and A type zeolites modified with paramagnetic species.

scholarly journals Polyhydroxylated GdDTPA-derivatives as high relaxivity magnetic resonance imaging contrast agents

RSC Advances ◽  
2015 ◽  
Vol 5 (91) ◽  
pp. 74734-74743 ◽  
Author(s):  
Lorenzo Tei ◽  
Alessandro Barge ◽  
Matteo Galli ◽  
Roberta Pinalli ◽  
Luciano Lattuada ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Resonance Imaging ◽  
High Relaxivity ◽  
Wide Range ◽  
Magnetic Resonance Imaging Contrast

Novel GdDTPA-like complexes bearing differently branched, highly hydrophilic, gluconyl moieties were synthesized to obtain high relaxivity agents (∼20 mM−1 s−1 at 25 °C) over a wide range of imaging fields (0.5–3 T).

Magnetic Resonance Imaging Contrast Agents and the Nuclear Pharmacist

1989 ◽  
Vol 2 (3) ◽  
pp. 191-195
Author(s):  
Jeffrey A. Clanton
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Resonance Imaging ◽  
Specific Group ◽  
The Past ◽  
Iodinated Contrast ◽  
Magnetic Resonance Imaging Contrast ◽  
Magnetic Resonance Imaging Mri ◽  
Insight Into

The nuclear pharmacist works with a very specific group of drugs. These drugs generally exhibit no toxic effects and are used almost exclusively for diagnosis. In the past these have been the radioactive drugs used in nuclear medicine and the iodinated contrast agents used in radiology. However, with the advent of magnetic resonance imaging (MRI), there is an additional class of drugs used in radiology, the magnetopharmaceuticals. These drugs are designed especially for increasing diagnostic sensitivity with MRI. This article is intended to provide topical insight into the basics of MRI and magnetopharmaceuticals.

scholarly journals High-Relaxivity Gadolinium-Modified High-Density Lipoproteins as Magnetic Resonance Imaging Contrast Agents

2009 ◽  
Vol 113 (18) ◽  
pp. 6283-6289 ◽  
Author(s):  
Karen C. Briley-Saebo ◽  
Simonetta Geninatti-Crich ◽  
David P. Cormode ◽  
Alessandra Barazza ◽  
Willem J. M. Mulder ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
High Density ◽  
High Density Lipoproteins ◽  
Resonance Imaging ◽  
High Relaxivity ◽  
Magnetic Resonance Imaging Contrast

scholarly journals High-Relaxivity Magnetic Resonance Imaging Contrast Agents Part 2

2010 ◽  
Vol 45 (10) ◽  
pp. 613-624 ◽  
Author(s):  
Vincent Jacques ◽  
Stéphane Dumas ◽  
Wei-Chuan Sun ◽  
Jeffrey S. Troughton ◽  
Matthew T. Greenfield ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Resonance Imaging ◽  
High Relaxivity ◽  
Magnetic Resonance Imaging Contrast
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