Temperature and ultrasound sensitive gatekeepers for the controlled release of chemotherapeutic drugs from mesoporous silica nanoparticles

2018 ◽  
Vol 6 (3) ◽  
pp. 428-439 ◽  
Author(s):  
T. S. Anirudhan ◽  
Anoop S. Nair
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Transdermal Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Chemotherapeutic Drugs ◽  
Stimuli Responsive ◽  
Internal Organs ◽  
Delivery Route

The copolymer chains were grafted onto the mesopores of silica nanoparticles and could act as stimuli responsive ‘smart’ gatekeepers. With the aid of a transdermal delivery route and ultrasound penetration, even malignant sites of internal organs can be set as targets.

Enzyme and voltage stimuli-responsive controlled release system based on β-cyclodextrin-capped mesoporous silica nanoparticles

2015 ◽  
Vol 44 (9) ◽  
pp. 4355-4361 ◽  
Author(s):  
Yu Xiao ◽  
Tao Wang ◽  
Yu Cao ◽  
Xue Wang ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Release System ◽  
Controlled Release System

This work demonstrated the development of a novel controlled release system, which is sensitive to enzyme and voltage stimuli, based on mesoporous silica nanoparticles functionalized by a ferrocene moiety with β-cyclodextrin as the nanovalve.

Smart mesoporous silica nanoparticles for controlled-release drug delivery

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Mahdi Karimi ◽  
Hamed Mirshekari ◽  
Masoumeh Aliakbari ◽  
Parham Sahandi-Zangabad ◽  
Michael R. Hamblin
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
High Capacity ◽  
Bioactive Molecules ◽  
Stimuli Responsive ◽  
Release Drug ◽  
Stimulus Responsive ◽  
External Stimuli

AbstractStimuli-responsive controlled-release nanocarriers are promising vehicles for delivery of bioactive molecules that can minimize side effects and maximize efficiency. The release of the drug occurs when the nanocarrier is triggered by an internal or external stimulus. Mesoporous silica nanoparticles (MSN) can have drugs and bioactive cargos loaded into the high-capacity pores, and their release can be triggered by activation of a variety of stimulus-responsive molecular “gatekeepers” or “nanovalves.” In this mini-review, we discuss the basic concepts of MSN in targeted drug-release systems and cover different stimulus-responsive gatekeepers. Internal stimuli include redox, enzymes, and pH, while external stimuli include light, ultrasound, and magnetic fields, and temperature can either be internal or external.

scholarly journals Correction: Enzyme and voltage stimuli-responsive controlled release system based on β-cyclodextrin-capped mesoporous silica nanoparticles

2015 ◽  
Vol 44 (17) ◽  
pp. 8300-8300 ◽  
Author(s):  
Yu Xiao ◽  
Tao Wang ◽  
Yu Cao ◽  
Xue Wang ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Dalton Trans ◽  
Release System ◽  
Controlled Release System

Correction for ‘Enzyme and voltage stimuli-responsive controlled release system based on β-cyclodextrin-capped mesoporous silica nanoparticles’ by Yu Xiao et al., Dalton Trans., 2015, 44, 4355–4361.

scholarly journals Mesoporous Silica Nanoparticles as Theranostic Antitumoral Nanomedicines

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 957
Author(s):  
Alejandro Baeza ◽  
Maria Vallet-Regí
Keyword(s):  
Mesoporous Silica ◽  
Contrast Agents ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Substantial Improvement ◽  
The State ◽  
Chemotherapeutic Drugs ◽  
Stimuli Responsive ◽  
Panoramic View ◽  
Excellent Control

Nanoparticles have become a powerful tool in oncology not only as carrier of the highly toxic chemotherapeutic drugs but also as imaging contrast agents that provide valuable information about the state of the disease and its progression. The enhanced permeation and retention effect for loaded nanocarriers in tumors allow substantial improvement of selectivity and safety of anticancer nanomedicines. Additionally, the possibility to design stimuli-responsive nanocarriers able to release their payload in response to specific stimuli provide an excellent control on the administered dosage. The aim of this review is not to present a comprehensive revision of the different theranostic mesoporous silica nanoparticles (MSN) which have been published in the recent years but just to describe a few selected examples to offer a panoramic view to the reader about the suitability and effectiveness of these nanocarriers in the oncology field.

scholarly journals Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 527 ◽  
Author(s):  
Sugata Barui ◽  
Valentina Cauda
Keyword(s):  
Controlled Release ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Cancer Therapeutics ◽  
High Loading ◽  
Active Targeting ◽  
Stimuli Responsive

The presence of leaky vasculature and the lack of lymphatic drainage of small structures by the solid tumors formulate nanoparticles as promising delivery vehicles in cancer therapy. In particular, among various nanoparticles, the mesoporous silica nanoparticles (MSN) exhibit numerous outstanding features, including mechanical thermal and chemical stability, huge surface area and ordered porous interior to store different anti-cancer therapeutics with high loading capacity and tunable release mechanisms. Furthermore, one can easily decorate the surface of MSN by attaching ligands for active targeting specifically to the cancer region exploiting overexpressed receptors. The controlled release of drugs to the disease site without any leakage to healthy tissues can be achieved by employing environment responsive gatekeepers for the end-capping of MSN. To achieve precise cancer chemotherapy, the most desired delivery system should possess high loading efficiency, site-specificity and capacity of controlled release. In this review we will focus on multimodal decorations of MSN, which is the most demanding ongoing approach related to MSN application in cancer therapy. Herein, we will report about the recently tried efforts for multimodal modifications of MSN, exploiting both the active targeting and stimuli responsive behavior simultaneously, along with individual targeted delivery and stimuli responsive cancer therapy using MSN.

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