Near-infrared light-responsive, diselenide containing core-cross-linked micelles prepared by the Diels–Alder click reaction for photocontrollable drug release application

2018 ◽  
Vol 9 (39) ◽  
pp. 4813-4823 ◽  
Author(s):  
Sabrina Aufar Salma ◽  
Maheshkumar Prakash Patil ◽  
Dong Woo Kim ◽  
Cuong Minh Quoc Le ◽  
Byung-Hyun Ahn ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Click Reaction ◽  
Diels Alder ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Micelle System ◽  
Drug Vehicle

We report a facile and efficient preparation of a NIR-triggered micelle system for a drug vehicle.

scholarly journals Near-Infrared Light-Responsive Shell-Crosslinked Micelles of Poly(d,l-lactide)-b-poly((furfuryl methacrylate)-co-(N-acryloylmorpholine)) Prepared by Diels–Alder Reaction for the Triggered Release of Doxorubicin

Materials ◽  
2021 ◽  
Vol 14 (24) ◽  
pp. 7913
Author(s):  
Sonyabapu Yadav ◽  
Kalyan Ramesh ◽  
Parveen Kumar ◽  
Sung-Han Jo ◽  
Seong II Yoo ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Click Reaction ◽  
In Vitro Cytotoxicity ◽  
Diels Alder ◽  
Infrared Light ◽  
Burst Release ◽  
Crosslinking Reaction ◽  
Triggered Release

In the present study, we developed near-infrared (NIR)-responsive shell-crosslinked (SCL) micelles using the Diels–Alder (DA) click reaction between an amphiphilic copolymer poly(d,l-lactide)20-b-poly((furfuryl methacrylate)10-co-(N-acryloylmorpholine)78) (PLA20-b-P(FMA10-co-NAM78)) and a diselenide-containing crosslinker, bis(maleimidoethyl) 3,3′-diselanediyldipropionoate (BMEDSeDP). The PLA20-b-P(FMA10-co-NAM78) copolymer was synthesized by RAFT polymerization of FMA and NAM using a PLA20-macro-chain transfer agent (PLA20-CTA). The DA reaction between BMEDSeDP and the furfuryl moieties in the copolymeric micelles in water resulted in the formation of SCL micelles. The SCL micelles were analyzed by 1H-NMR, FE-SEM, and DLS. An anticancer drug, doxorubicin (DOX), and an NIR sensitizer, indocyanine green (ICG), were effectively incorporated into the SCL micelles during the crosslinking reaction. The DOX/ICG-loaded SCL micelles showed pH- and NIR-responsive drug release, where burst release was observed under NIR laser irradiation. The in vitro cytotoxicity analysis demonstrated that the SCL was not cytotoxic against normal HFF-1 cells, while DOX/ICG-loaded SCL micelles exhibited significant antitumor activity toward HeLa cells. Thus, the SCL micelles of PLA20-b-P(FMA10-co-NAM78) can be used as a potential delivery vehicle for the controlled drug release in cancer therapy.

Near-infrared light-triggered drug release from UV-responsive diblock copolymer-coated upconversion nanoparticles with high monodispersity

2018 ◽  
Vol 6 (21) ◽  
pp. 3531-3540 ◽  
Author(s):  
Jun Xiang ◽  
Xia Tong ◽  
Feng Shi ◽  
Qiang Yan ◽  
Bing Yu ◽  
...  
Keyword(s):  
Drug Release ◽  
Diblock Copolymer ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light ◽  
Nir Light ◽  
Triggered Drug Release

The preparation of a new near-infrared (NIR) light-responsive nanocarrier for controlled drug release is demonstrated.

Near-Infrared-Light-Induced Fast Drug Release Platform: Mesoporous Silica-Coated Gold Nanoframes for Thermochemotherapy

2016 ◽  
Vol 33 (6) ◽  
pp. 316-322 ◽  
Author(s):  
Haosha Tang ◽  
Liangqing Yao ◽  
Jianping Yang ◽  
Wei Li ◽  
Zhaogang Teng ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light

Phospholipid-based self-assembled mesophase systems for light-activated drug delivery

2015 ◽  
Vol 17 (21) ◽  
pp. 14021-14027 ◽  
Author(s):  
Joanne D. Du ◽  
Wye-Khay Fong ◽  
Stefan Salentinig ◽  
Suzanne M. Caliph ◽  
Adrian Hawley ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Self Assembled

Biocompatible phospholipid–cholesterol matrix undergoes photothermal transition on irradiation with near infrared light for drug release applications.

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