The unusual aggregation-induced emission of coplanar organoboron isomers and their lipid droplet-specific applications

2018 ◽  
Vol 2 (8) ◽  
pp. 1498-1507 ◽  
Author(s):  
Jen-Shyang Ni ◽  
Haixiang Liu ◽  
Junkai Liu ◽  
Meijuan Jiang ◽  
Zheng Zhao ◽  
...  
Keyword(s):  
Excited State ◽  
Double Bond ◽  
Lipid Droplet ◽  
Lipid Droplets ◽  
Aggregation Induced Emission ◽  
Bond Reorganization

Organoboron isomers are not only rare coplanar AIEgens stemmed from excited-state double-bond reorganization, but also specifically target lipid droplets.

A highly selective AIE fluorogen for lipid droplet imaging in live cells and green algae

2014 ◽  
Vol 2 (14) ◽  
pp. 2013-2019 ◽  
Author(s):  
Erjing Wang ◽  
Engui Zhao ◽  
Yuning Hong ◽  
Jacky W. Y. Lam ◽  
Ben Zhong Tang
Keyword(s):  
Green Algae ◽  
Lipid Droplet ◽  
Lipid Droplets ◽  
High Selectivity ◽  
High Specificity ◽  
Live Cells ◽  
Aggregation Induced Emission ◽  
Low Cytotoxicity ◽  
Excellent Photostability

An aggregation-induced emission fluorogen, TPE-AmAl, is reported to selectively image lipid droplets in live cells and green algae with high selectivity, high specificity, excellent photostability and low cytotoxicity.

Evidence for Aggregation-Induced Emission from Free Rotation Restriction of Double Bond at Excited State

2018 ◽  
Vol 20 (2) ◽  
pp. 373-376 ◽  
Author(s):  
Jia-Bin Xiong ◽  
Ying-Xue Yuan ◽  
Lian Wang ◽  
Jian-Ping Sun ◽  
Wei-Guo Qiao ◽  
...  
Keyword(s):  
Excited State ◽  
Double Bond ◽  
Free Rotation ◽  
Aggregation Induced Emission

Facile construction of boranil complexes with aggregation-induced emission characteristics and their specific lipid droplet imaging applications

2019 ◽  
Vol 55 (58) ◽  
pp. 8494-8497 ◽  
Author(s):  
Na Zhao ◽  
Chengcheng Ma ◽  
Weiyao Yang ◽  
Wei Yin ◽  
Jiahui Wei ◽  
...  
Keyword(s):  
Lipid Droplet ◽  
Lipid Droplets ◽  
Living Cells ◽  
Emission Characteristics ◽  
Aggregation Induced Emission ◽  
Specific Lipid

A series of boranil complexes with aggregation-induced emission effects were facilely constructed, which can be utilized to image lipid droplets in living cells and yolk lipids in zebrafish.

scholarly journals Drawing a clear mechanistic picture for the aggregation-induced emission process

2019 ◽  
Vol 3 (6) ◽  
pp. 1143-1150 ◽  
Author(s):  
Haoke Zhang ◽  
Junkai Liu ◽  
Lili Du ◽  
Chao Ma ◽  
Nelson L. C. Leung ◽  
...  
Keyword(s):  
Excited State ◽  
Double Bond ◽  
Emission Process ◽  
Aggregation Induced Emission

Excited-state “double-bond” torsion plays an important role in the nonluminescent behaviour of a stilbene-based twisted isomer.

scholarly journals Indolylbenzothiadiazoles as highly tunable fluorophores for imaging lipid droplet accumulation in astrocytes and glioblastoma cells

RSC Advances ◽  
2021 ◽  
Vol 11 (39) ◽  
pp. 23960-23967
Author(s):  
Kilian Colas ◽  
Karl O. Holmberg ◽  
Linus Chiang ◽  
Susanne Doloczki ◽  
Fredrik J. Swartling ◽  
...  
Keyword(s):  
Lipid Droplet ◽  
Lipid Droplets ◽  
Glioblastoma Cells ◽  
Photophysical Study

We present an extensive photophysical study of a series of fluorescent indolylbenzothiadiazole derivatives and their ability to specifically image lipid droplets in astrocytes and glioblastoma cells.

Identification of Perilipin-2 as a lipid droplet protein regulated in oocytes during maturation

2010 ◽  
Vol 22 (8) ◽  
pp. 1262 ◽  
Author(s):  
Xing Yang ◽  
Kylie R. Dunning ◽  
Linda L.-Y. Wu ◽  
Theresa E. Hickey ◽  
Robert J. Norman ◽  
...  
Keyword(s):  
Lipid Droplet ◽  
Lipid Content ◽  
Lipid Droplets ◽  
Intracellular Lipids ◽  
Epidermal Growth ◽  
Novel Method ◽  
Perilipin 2 ◽  
Lipid Droplet Protein

Lipid droplet proteins regulate the storage and utilisation of intracellular lipids. Evidence is emerging that oocyte lipid utilisation impacts embryo development, but lipid droplet proteins have not been studied in oocytes. The aim of the present study was to characterise the size and localisation of lipid droplets in mouse oocytes during the periovulatory period and to identify lipid droplet proteins as potential biomarkers of oocyte lipid content. Oocyte lipid droplets, visualised using a novel method of staining cumulus–oocyte complexes (COCs) with BODIPY 493/503, were small and diffuse in oocytes of preovulatory COCs, but larger and more centrally located after maturation in response to ovulatory human chorionic gonadotrophin (hCG) in vivo, or FSH + epidermal growth factor in vitro. Lipid droplet proteins Perilipin, Perilipin-2, cell death-inducing DNA fragmentation factor 45-like effector (CIDE)-A and CIDE-B were detected in the mouse ovary by immunohistochemistry, but only Perilipin-2 was associated with lipid droplets in the oocyte. In COCs, Perilipin-2 mRNA and protein increased in response to ovulatory hCG. IVM failed to induce Perilipin-2 mRNA, yet oocyte lipid content was increased in this context, indicating that Perilipin-2 is not necessarily reflective of relative oocyte lipid content. Thus, Perilipin-2 is a lipid droplet protein in oocytes and its induction in the COC concurrent with dynamic reorganisation of lipid droplets suggests marked changes in lipid utilisation during oocyte maturation.

Excited state dynamics for hybridized local and charge transfer state fluorescent emitters with aggregation-induced emission in the solid phase: a QM/MM study

2017 ◽  
Vol 19 (44) ◽  
pp. 29872-29879 ◽  
Author(s):  
Jianzhong Fan ◽  
Lei Cai ◽  
Lili Lin ◽  
Chuan-Kui Wang
Keyword(s):  
Excited State ◽  
Charge Transfer ◽  
Solid Phase ◽  
Charge Transfer State ◽  
Aggregation Induced Emission ◽  
Excited State Dynamics ◽  
Transfer State

Investigation on the excited state dynamics to reveal the AIE and HLCT mechanisms by a QM/MM method.

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