Cancer-targeted reactive oxygen species-degradable polymer nanoparticles for near infrared light-induced drug release

2018 ◽  
Vol 6 (46) ◽  
pp. 7737-7749 ◽  
Author(s):  
Geok Leng Seah ◽  
Jeong Heon Yu ◽  
Bon Il Koo ◽  
Dong Jae Lee ◽  
Yoon Sung Nam
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Near Infrared ◽  
Peripheral Region ◽  
Polymer Nanoparticles ◽  
Infrared Light ◽  
Oxygen Species ◽  
Degradable Polymer ◽  
Enhanced Permeability And Retention ◽  
Tumor Tissues

Nanocarriers can be translocated to the peripheral region of tumor tissues through the well-known enhanced permeability and retention effects.

Near infrared light triggered reactive oxygen species responsive nanoparticles for chemo-photodynamic combined therapy

2018 ◽  
Vol 6 (15) ◽  
pp. 2347-2357 ◽  
Author(s):  
Xuefei Zhang ◽  
Binyao Huang ◽  
Yifeng Shen ◽  
Chanzhen Yang ◽  
Zeqian Huang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Near Infrared ◽  
Combined Therapy ◽  
Reactive Oxygen ◽  
Infrared Light ◽  
Oxygen Species ◽  
Near Infrared Light

Nanoparticles with ROS-responsive properties could realize spatial and temporal drug release under NIR irradiation and the excess ROS could be used for PDT.

Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapyin Vitro

ACS Nano ◽  
2014 ◽  
Vol 8 (7) ◽  
pp. 7260-7271 ◽  
Author(s):  
Liang Gao ◽  
Ru Liu ◽  
Fuping Gao ◽  
Yaling Wang ◽  
Xinglu Jiang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Infrared Light ◽  
Oxygen Species ◽  
Near Infrared Light ◽  
Gold Nanocages

A Janus upconverting nanoplatform with biodegradability for glutathione depletion, near-infrared light induced photodynamic therapy and accelerated excretion

2020 ◽  
Vol 8 (40) ◽  
pp. 9251-9257
Author(s):  
Hang Zhou ◽  
Qunying Li ◽  
Xi Cheng ◽  
Chao Zhang ◽  
Jiawei Sun ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Near Infrared ◽  
Glutathione Depletion ◽  
Infrared Light ◽  
Oxygen Species ◽  
Tissue Penetration ◽  
Excitation Light ◽  
The Poor

The major limitations of photodynamic therapy (PDT) are the poor tissue penetration of excitation light and the neutralization of reactive oxygen species (ROS) generated by overexpressed glutathione (GSH) in cancer cells.

scholarly journals Mesoporous semiconductors combined with up-conversion nanoparticles for enhanced photodynamic therapy under near infrared light

RSC Advances ◽  
2019 ◽  
Vol 9 (30) ◽  
pp. 17273-17280 ◽  
Author(s):  
Fan Yang ◽  
Jun Liu ◽  
Xue Jiang ◽  
Weiwei Wu ◽  
Zhenni Wang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Cells ◽  
Near Infrared ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Infrared Light ◽  
Oxygen Species ◽  
Near Infrared Light

Photodynamic therapy (PDT) is a promising and effective method for tumor therapy that relies on the reactive oxygen species (ROS) produced by photosensitizers at specific wavelengths to inhibit tumor cells.

scholarly journals Photoactivated nanomotors via aggregation induced emission for enhanced phototherapy

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shoupeng Cao ◽  
Jingxin Shao ◽  
Hanglong Wu ◽  
Shidong Song ◽  
Maria Teresa De Martino ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Near Infrared ◽  
Radiant Energy ◽  
Reactive Oxygen ◽  
Infrared Light ◽  
Oxygen Species ◽  
Directed Motion ◽  
Aggregation Induced Emission

AbstractAggregation-induced emission (AIE) has, since its discovery, become a valuable tool in the field of nanoscience. AIEgenic molecules, which display highly stable fluorescence in an assembled state, have applications in various biomedical fields—including photodynamic therapy. Engineering structure-inherent, AIEgenic nanomaterials with motile properties is, however, still an unexplored frontier in the evolution of this potent technology. Here, we present phototactic/phototherapeutic nanomotors where biodegradable block copolymers decorated with AIE motifs can transduce radiant energy into motion and enhance thermophoretic motility driven by an asymmetric Au nanoshell. The hybrid nanomotors can harness two photon near-infrared radiation, triggering autonomous propulsion and simultaneous phototherapeutic generation of reactive oxygen species. The potential of these nanomotors to be applied in photodynamic therapy is demonstrated in vitro, where near-infrared light directed motion and reactive oxygen species induction synergistically enhance efficacy with a high level of spatial control.

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