scholarly journals Boosting the antimicrobial action of vancomycin formulated in shellac nanoparticles of dual-surface functionality

2019 ◽  
Vol 7 (19) ◽  
pp. 3119-3133 ◽  
Author(s):  
Saba S. M. Al-Obaidy ◽  
Ahmed F. Halbus ◽  
Gillian M. Greenway ◽  
Vesselin N. Paunov
Keyword(s):  
Cell Membranes ◽  
Microbial Cell ◽  
Antimicrobial Action ◽  
Surface Functionality ◽  
Strong Enhancement

We demonstrate a strong enhancement of the antimicrobial action of vancomycin encapsulated in shellac nanocarriers with cationic surface functionality which concentrate on the microbial cell membranes.

scholarly journals Dual-functionalised shellac nanocarriers give a super-boost of the antimicrobial action of berberine

2019 ◽  
Vol 1 (2) ◽  
pp. 858-872 ◽  
Author(s):  
Saba S. M. Al-Obaidy ◽  
Gillian M. Greenway ◽  
Vesselin N. Paunov
Keyword(s):  
Cell Walls ◽  
Local Delivery ◽  
Microbial Cell ◽  
Antimicrobial Action ◽  
Surface Functionality ◽  
Strong Enhancement ◽  
Electrostatic Adhesion

We demonstrate a strong enhancement of the antimicrobial action of berberine encapsulated in shellac nanoparticles with dual surface functionality. This is attributed to the electrostatic adhesion of the cationic nanocarriers to the microbial cell walls which leads to their accumulation and local delivery of berberine.

scholarly journals Amplified antimicrobial action of chlorhexidine encapsulated in PDAC-functionalized acrylate copolymer nanogel carriers

2018 ◽  
Vol 2 (11) ◽  
pp. 2032-2044 ◽  
Author(s):  
Mohammed J. Al-Awady ◽  
Paul J. Weldrick ◽  
Matthew J. Hardman ◽  
Gillian M. Greenway ◽  
Vesselin N. Paunov
Keyword(s):  
Cell Membrane ◽  
Cell Walls ◽  
Local Delivery ◽  
Microbial Cell ◽  
Antimicrobial Action ◽  
Strong Enhancement ◽  
Acrylate Copolymer ◽  
Electrostatic Adhesion

We demonstrate a strong enhancement of the antimicrobial action of chlorhexidine which is attributed to the electrostatic adhesion of the cationic nanocarriers on the microbial cell walls which leads to their accumulation and local delivery of chlorhexidine directly on to the microbial cell membrane.

scholarly journals Self-grafting copper oxide nanoparticles show a strong enhancement of their anti-algal and anti-yeast action

2019 ◽  
Vol 1 (6) ◽  
pp. 2323-2336 ◽  
Author(s):  
Ahmed F. Halbus ◽  
Tommy S. Horozov ◽  
Vesselin N. Paunov
Keyword(s):  
Copper Oxide ◽  
Functional Groups ◽  
Cell Membranes ◽  
Covalent Binding ◽  
Copper Oxide Nanoparticles ◽  
Cuo Nanoparticles ◽  
Oxide Nanoparticles ◽  
Strong Enhancement

We report a strong amplification of the anti-algal and anti-yeast action of CuO nanoparticles surface-grafted with 4-hydroxyphenylboronic acid functional groups due to their covalent binding to carbohydrates on the cell membranes.

scholarly journals Role of Nanoparticle Surface Functionality in the Disruption of Model Cell Membranes

Langmuir ◽  
2012 ◽  
Vol 28 (47) ◽  
pp. 16318-16326 ◽  
Author(s):  
Babak Y. Moghadam ◽  
Wen-Che Hou ◽  
Charlie Corredor ◽  
Paul Westerhoff ◽  
Jonathan D. Posner
Keyword(s):  
Cell Membranes ◽  
Surface Functionality ◽  
Nanoparticle Surface ◽  
Model Cell

scholarly journals Enhanced Antimicrobial Action of Chlorhexidine Loaded in Shellac Nanoparticles with Cationic Surface Functionality

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1389
Author(s):  
Saba S. M. Al-Obaidy ◽  
Gillian M. Greenway ◽  
Vesselin N. Paunov
Keyword(s):  
Release Kinetics ◽  
Antimicrobial Action ◽  
Poloxamer 407 ◽  
Ammonium Bromide ◽  
The Novel ◽  
High Concentration ◽  
Oral Infections ◽  
Surface Functionality ◽  
Negative Surface ◽  
Co Precipitation

We report on an active nanocarrier for chlorhexidine (CHX) based on sterically stabilized shellac nanoparticles (NPs) with dual surface functionalization, which greatly enhances the antimicrobial action of CHX. The fabrication process for the CHX nanocarrier is based on pH-induced co-precipitation of CHX-DG from an aqueous solution of ammonium shellac and Poloxamer 407 (P407), which serves as a steric stabilizing agent. This is followed by further surface modification with octadecyl trimethyl ammonium bromide (ODTAB) through a solvent change to yield cationic surface functionality. In this study, we assessed the encapsulation efficiency and release kinetics of the novel nanocarrier for CHX. We further examined the antimicrobial effects of the CHX nanocarriers and their individual components in order to gain better insight into how they work, to improve their design and to explore the impacts of their dual functionalization. The antimicrobial actions of CHX loaded in shellac NPs were examined on three different proxy microorganisms: a Gram-negative bacterium (E. coli), a yeast (S. cerevisiae) and a microalgae (C. reinhardtii). The antimicrobial actions of free CHX and CHX-loaded shellac NPs were compared over the same CHX concentration range. We found that the non-coated shellac NPs loaded with CHX showed inferior action compared with free CHX due to their negative surface charge; however, the ODTAB-coated, CHX-loaded shellac NPs strongly amplified the antimicrobial action of the CHX for the tested microorganisms. The enhancement of the CHX antimicrobial action was thought to be due to the increased electrostatic adhesion between the cationic surface of the ODTAB-coated, CHX-loaded shellac NPs and the anionic surface of the cell walls of the microorganisms, ensuring direct delivery of CHX with a high concentration locally on the cell membrane. The novel CHX nanocarriers with enhanced antimicrobial action may potentially find applications in dentistry for the development of more efficient formulations against conditions such as gingivitis, periodontitis and other oral infections, as well as enabling formulations to have lower CHX concentrations.

Branched-Chain Fatty Acid Content Modulates Structure, Fluidity, and Phase in Model Microbial Cell Membranes

2019 ◽  
Vol 123 (27) ◽  
pp. 5814-5821 ◽  
Author(s):  
Barmak Mostofian ◽  
Tony Zhuang ◽  
Xiaolin Cheng ◽  
Jonathan D. Nickels
Keyword(s):  
Fatty Acid ◽  
Acid Content ◽  
Cell Membranes ◽  
Fatty Acid Content ◽  
Chain Fatty Acid ◽  
Microbial Cell ◽  
Branched Chain

scholarly journals Enhanced antimicrobial effect of berberine in nanogel carriers with cationic surface functionality

2017 ◽  
Vol 5 (38) ◽  
pp. 7885-7897 ◽  
Author(s):  
Mohammed J. Al-Awady ◽  
Adelaide Fauchet ◽  
Gillian M. Greenway ◽  
Vesselin N. Paunov
Keyword(s):  
Cell Wall ◽  
Antimicrobial Effect ◽  
Cationic Polyelectrolyte ◽  
Surface Functionality ◽  
Strong Enhancement ◽  
Antifungal Action ◽  
Electrostatic Adhesion

We demonstrate a strong enhancement in the antimicrobial and antifungal action of berberine encapsulated in nanogel carriers whose surface is functionalised with a cationic polyelectrolyte. The effect comes from the electrostatic adhesion of the cationic nanocarriers on the cell wall.

Photoreceptor disk membrane substructures by means of the complementary freeze-fracture-replica methods

1978 ◽  
Vol 36 (2) ◽  
pp. 156-157
Author(s):  
A. Tonosaki ◽  
M. Yamasaki ◽  
H. Washioka ◽  
J. Mizoguchi
Keyword(s):  
Cell Membranes ◽  
Freeze Fracture ◽  
Purple Membrane ◽  
Remarkable Case ◽  
Single Face ◽  
Disk Membrane ◽  
Associated Proteins ◽  
Photoreceptor Membranes

A vertebrate disk membrane is composed of 40 % lipids and 60 % proteins. Its fracture faces have been classed into the plasmic (PF) and exoplasmic faces (EF), complementary with each other, like those of most other types of cell membranes. The hypothesis assuming the PF particles as representing membrane-associated proteins has been challenged by serious questions if they in fact emerge from the crystalline formation or decoration effects during freezing and shadowing processes. This problem seems to be yet unanswered, despite the remarkable case of the purple membrane of Halobacterium, partly because most observations have been made on the replicas from a single face of specimen, and partly because, in the case of photoreceptor membranes, the conformation of a rhodopsin and its relatives remains yet uncertain. The former defect seems to be partially fulfilled with complementary replica methods.

Introduction to Cell Membranes at Molecular Resolution

1978 ◽  
Vol 36 (3) ◽  
pp. 497-502
Author(s):  
R.J. Barrnett
Keyword(s):  
Cell Membranes ◽  
International Federation ◽  
Mountain Range ◽  
Cellular Membranes ◽  
Short History ◽  
Biological Organization ◽  
Macromolecular Assemblies ◽  
The Past

This subject, is like observing the panorama of a mountain range, magnificent towering peaks, but it doesn't take much duration of observation to recognize that they are still in the process of formation. The mountains consist of approaches, materials and methods and the rocky substance of information has accumulated to such a degree that I find myself concentrating on the foothills in the foreground in order to keep up with the advance; the edifices behind form a wonderous, substantive background. It's a short history for such an accumulation and much of it has been moved by the members of the societies that make up this International Federation. My panel of speakers are here to provide what we hope is an interesting scientific fare, based on the fact that there is a continuum of biological organization from biochemical molecules through macromolecular assemblies and cellular membranes to the cell itself. Indeed, this fact explains the whole range of towering peaks that have emerged progressively during the past 25 years.

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