Development of an endoplasmic reticulum-targeting fluorescent probe for the two-photon imaging of hypochlorous acid (HClO) in living cells

2019 ◽  
Vol 11 (35) ◽  
pp. 4450-4455 ◽  
Author(s):  
Wenhui Song ◽  
Baoli Dong ◽  
Yaru Lu ◽  
Xiuqi Kong ◽  
Abdul Hadi Mehmood ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Fluorescent Probe ◽  
Hypochlorous Acid ◽  
Living Cells ◽  
Oxygen Species ◽  
Cell Dysfunction ◽  
Two Photon ◽  
Endoplasmic Reticulum Targeting

As an important reactive oxygen species, hypochlorous acid (HClO) could irreversibly destroy Ca2+-ATPase to inhibit Ca2+ transport in the endoplasmic reticulum (ER), which may eventually lead to cell dysfunction and cell death.

An endoplasmic reticulum-targeting and ratiometric fluorescent probe for hypochlorous acid in living cells based on a 1,8-naphthalimide derivative

2020 ◽  
Vol 44 (42) ◽  
pp. 18389-18398
Author(s):  
Qiujuan Ma ◽  
Chunyan Wang ◽  
Guojiang Mao ◽  
Meiju Tian ◽  
Jingguo Sun ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Fluorescent Probe ◽  
Hypochlorous Acid ◽  
Living Cells ◽  
Endoplasmic Reticulum Targeting ◽  
Ratiometric Fluorescent Probe

A novel reticulum-targeting and ratiometric fluorescent probe for determining hypochlorous acid has been developed.

A two-photon endoplasmic reticulum-targeting fluorescent probe for the imaging of pH in living cells and zebrafish

2018 ◽  
Vol 10 (47) ◽  
pp. 5702-5706 ◽  
Author(s):  
Nan Zhang ◽  
Baoli Dong ◽  
Xiuqi Kong ◽  
Wenhui Song ◽  
Weiying Lin
Keyword(s):  
Endoplasmic Reticulum ◽  
Fluorescent Probe ◽  
Living Cells ◽  
Ph Changes ◽  
Two Photon ◽  
Endoplasmic Reticulum Targeting

The pH changes of the endoplasmic reticulum (ER) are closely related to many diseases.

A two-photon fluorescent probe for ratiometric imaging of endogenous hypochlorous acid in live cells and tissues

2017 ◽  
Vol 53 (78) ◽  
pp. 10800-10803 ◽  
Author(s):  
Yong Woong Jun ◽  
Sourav Sarkar ◽  
Subhankar Singha ◽  
Ye Jin Reo ◽  
Hye Rim Kim ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Fluorescent Probe ◽  
Hypochlorous Acid ◽  
Reactive Oxygen ◽  
Live Cells ◽  
Oxygen Species ◽  
Two Photon ◽  
Ratiometric Imaging ◽  
In Cells

A fluorescent probe enables two-photon ratiometric imaging of endogenous hypochlorous acid, a reactive oxygen species, in cells and tissues.

Colorimetric and Fluorescent Probe for Hypochlorite with High Selectivity

2013 ◽  
Vol 295-298 ◽  
pp. 475-478 ◽  
Author(s):  
Zhi Xiang Han ◽  
Ming Hui Du ◽  
Guo Xi Liang ◽  
Xiang Yang Wu
Keyword(s):  
Reactive Oxygen Species ◽  
Aqueous Solution ◽  
Detection Limit ◽  
Fluorescent Probe ◽  
Rhodamine B ◽  
High Selectivity ◽  
Reactive Oxygen ◽  
Living Cells ◽  
Oxygen Species ◽  
Turn On

Rhodamine B thiohydrazide (RBS) was firstly employed as turn-on fluorescent probe for hypochlorite in aqueous solution and living cells. It exhibits a stable response to hypochlorite from 1.0×10-6to 1.0×10-5M with a detection limit of 3.3×10-7M. The response of this probe to hypochlorite is fast and highly selective compared with other reactive oxygen species (such as.OH,1O2, H2O2) and other common anions (such as X-, ClO2-, ClO4-, NO3-, NO2-, OH-, Ac-, CO32-, SO42-).

Two-photon fluorescent probe for lysosome-targetable hypochlorous acid detection within living cells

2018 ◽  
Vol 255 ◽  
pp. 2223-2231 ◽  
Author(s):  
Peisheng Zhang ◽  
Hong Wang ◽  
Di Zhang ◽  
Xuyao Zeng ◽  
Rongjin Zeng ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Hypochlorous Acid ◽  
Living Cells ◽  
Two Photon
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