Cell-penetrating peptide together with PEG-modified mesostructured silica nanoparticles promotes mucous permeation and oral delivery of therapeutic proteins and peptides

2019 ◽  
Vol 7 (7) ◽  
pp. 2934-2950 ◽  
Author(s):  
Xinyi Tan ◽  
Yan Zhang ◽  
Qian Wang ◽  
Tianyang Ren ◽  
Jingxin Gou ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Oral Delivery ◽  
Therapeutic Proteins ◽  
Cell Penetrating Peptide ◽  
Modified Silica ◽  
Mesostructured Silica ◽  
Cell Penetrating ◽  
Proteins And Peptides

Electrostatic particle complexes, CPP/TPP/NP, consisting of PEG-modified silica NPs with TPP and CPP, showed satisfactory stability and mucous penetration.

Cationic chitosan‐modified silica nanoparticles for oral delivery of protein vaccine

2021 ◽  
Author(s):  
Xi Wu ◽  
Muhammad Asim Farooq ◽  
Tiantian Li ◽  
Tianjiao Geng ◽  
Perpeuta Takunda Kutoka ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Oral Delivery ◽  
Protein Vaccine ◽  
Modified Silica ◽  
Modified Silica Nanoparticles

Thiolation and Cell-Penetrating Peptide Surface Functionalization of Porous Silicon Nanoparticles for Oral Delivery of Insulin

2016 ◽  
Vol 26 (20) ◽  
pp. 3405-3416 ◽  
Author(s):  
Neha Shrestha ◽  
Francisca Araújo ◽  
Mohammad-Ali Shahbazi ◽  
Ermei Mäkilä ◽  
Maria João Gomes ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Surface Functionalization ◽  
Oral Delivery ◽  
Silicon Nanoparticles ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Porous Silicon Nanoparticles

scholarly journals Interdependence of charge and secondary structure on cellular uptake of cell penetrating peptide functionalized silica nanoparticles

2020 ◽  
Vol 2 (1) ◽  
pp. 453-462 ◽  
Author(s):  
Isabel Gessner ◽  
Annika Klimpel ◽  
Merlin Klußmann ◽  
Ines Neundorf ◽  
Sanjay Mathur
Keyword(s):  
Secondary Structure ◽  
Silica Nanoparticles ◽  
Cellular Uptake ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating Peptide ◽  
Functionalized Silica ◽  
Biological Barriers ◽  
Drug Molecules ◽  
Cell Penetrating ◽  
Functionalized Silica Nanoparticles

The capability of cell-penetrating peptides (CPPs) to enable translocation of cargos across biological barriers shows promising pharmaceutical potential for the transport of drug molecules, as well as nanomaterials, into cells.

scholarly journals Oral delivery of therapeutic proteins and peptides: a review on recent developments

Drug Delivery ◽  
2013 ◽  
Vol 20 (6) ◽  
pp. 237-246 ◽  
Author(s):  
Sonal Gupta ◽  
Arushi Jain ◽  
Mainak Chakraborty ◽  
Jasjeet K Sahni ◽  
Javed Ali ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Therapeutic Proteins ◽  
Recent Developments ◽  
Proteins And Peptides
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