Mesoporous silica nanobeans dual-functionalized with AIEgens and leaning pillar[6]arene-based supramolecular switches for imaging and stimuli-responsive drug release

2019 ◽  
Vol 55 (94) ◽  
pp. 14099-14102 ◽  
Author(s):  
Xiangshuai Li ◽  
Junyou Han ◽  
Jianchun Qin ◽  
Ming Sun ◽  
Jiarui Wu ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Stimuli Responsive ◽  
Tumor Inhibition ◽  
Turn On ◽  
Functionalized Mesoporous Silica

Dual-functionalized mesoporous silica nanobeans capable of GSH-dependent turn-on fluorescence and stimuli-responsive drug release are prepared for tumor inhibition and imaging.

scholarly journals Stimuli-responsive functionalized mesoporous silica nanoparticles for drug release in response to various biological stimuli

2014 ◽  
Vol 2 (1) ◽  
pp. 121-130 ◽  
Author(s):  
Xin Chen ◽  
Xiaoyu Cheng ◽  
Alexander H. Soeriyadi ◽  
Sharon M. Sagnella ◽  
Xun Lu ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Functionalized Mesoporous Silica

Influence of functionalized mesoporous silica in controlling azathioprine drug release and cytotoxicity properties

2017 ◽  
Vol 21 (7) ◽  
pp. 413-425 ◽  
Author(s):  
Suman Jangra ◽  
Surender Duhan ◽  
Manjeet Singh Goyat ◽  
Vinod Chhokar ◽  
Sandeep Singh ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Functionalized Mesoporous Silica

Size-Controlled Functionalized Mesoporous Silica Nanoparticles for Tunable Drug Release and Enhanced Anti-Tumoral Activity

2016 ◽  
Vol 28 (12) ◽  
pp. 4243-4258 ◽  
Author(s):  
Meryem Bouchoucha ◽  
Marie-France Côté ◽  
René C.-Gaudreault ◽  
Marc-André Fortin ◽  
Freddy Kleitz
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica ◽  
Size Controlled

Bioresponsive carbon nano-gated multifunctional mesoporous silica for cancer theranostics

Nanoscale ◽  
2016 ◽  
Vol 8 (8) ◽  
pp. 4537-4546 ◽  
Author(s):  
Rajendra Prasad ◽  
Sandhya Aiyer ◽  
Deepak S. Chauhan ◽  
Rohit Srivastava ◽  
Kaliaperumal Selvaraj
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Theranostic Agent ◽  
Functionalized Mesoporous Silica ◽  
Dual Functional ◽  
Successful Design ◽  
Bio Imaging ◽  
Green Fluorescent ◽  
Cancer Theranostics

A successful design of a novel dual functional green fluorescent CQD functionalized mesoporous silica based nano-theranostic agent for targeted bio-imaging and bio-responsive drug release has been reported. This study proves that the release of a preloaded anticancer drug is triggered by exposure to a tumor like environment which makes it an efficient theranostic system for cancer therapy.

Hybrid lipid-mesoporous silica for stimuli-responsive drug release and overcoming multidrug resistance

2015 ◽  
Vol 213 ◽  
pp. e84 ◽  
Author(s):  
Ning Han ◽  
Qinfu Zhao ◽  
Long Wan ◽  
Ying Wang ◽  
Yikun Gao ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Stimuli Responsive

scholarly journals Controlled release evaluation of paracetamol loaded amine functionalized mesoporous silica KCC1 compared to microcrystalline cellulose based tablets

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marieh Pishnamazi ◽  
Hamid Hafizi ◽  
Mahboubeh Pishnamazi ◽  
Azam Marjani ◽  
Saeed Shirazian ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Microcrystalline Cellulose ◽  
Release Rate ◽  
Drug Carriers ◽  
Release Behavior ◽  
Drug Controlled Release ◽  
Remarkable Effect ◽  
Functionalized Mesoporous Silica

AbstractIn the pharmaceutical manufacturing, drug release behavior development is remained as one of the main challenges to improve the drug effectiveness. Recently, more focus has been done on using mesoporous silica materials as drug carriers for prolonged and superior control of drug release in human body. In this study, release behavior of paracetamol is developed using drug-loaded KCC-1-NH2 mesoporous silica, based on direct compaction method for preparation of tablets. The purpose of this study is to investigate the utilizing of pure KCC-1 mesoporous silica (KCC-1) and amino functionalized KCC-1 (KCC-1-NH2) as drug carriers in oral solid dosage formulations compared to common excipient, microcrystalline cellulose (MCC), to improve the control of drug release rate by manipulating surface chemistry of the carrier. Different formulations of KCC-1 and KCC-NH2 are designed to investigate the effect of functionalized mesoporous silica as carrier on drug controlled-release rate. The results displayed the remarkable effect of KCC-1-NH2 on drug controlled-release in comparison with the formulation containing pure KCC-1 and formulation including MCC as reference materials. The pure KCC-1 and KCC-1-NH2 are characterized using different evaluation methods such as FTIR, SEM, TEM and N2 adsorption analysis.

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