Covalently assembled dopamine nanoparticle as an intrinsic photosensitizer and pH-responsive nanocarrier for potential application in anticancer therapy

2019 ◽  
Vol 55 (100) ◽  
pp. 15057-15060 ◽  
Author(s):  
Hong Li ◽  
Yuanyuan Zhao ◽  
Yi Jia ◽  
Chengtun Qu ◽  
Junbai Li
Keyword(s):  
Potential Application ◽  
Anticancer Therapy ◽  
Ph Responsive

A covalently assembled dopamine nanoparticle is constructed to serve as an intrinsic photosensitizer and pH-responsive drug nanocarrier for combined PDT and chemotherapy.

pH-responsive size-shrinkable mesoporous silica-based nanocarrier for improved tumor penetration and therapeutic efficacy

Nanoscale ◽  
2022 ◽  
Author(s):  
Yongju He ◽  
Xingyu Fan ◽  
Xiaozan Wu ◽  
Taishun Hu ◽  
Fangfang Zhou ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Mesoporous Silica ◽  
Therapeutic Efficacy ◽  
Anticancer Therapy ◽  
Major Obstacle ◽  
Drug Penetration ◽  
Ph Responsive ◽  
Tumor Penetration ◽  
Promising Strategy

Poor tumor penetration is a major obstacle to nanomedicine for achieving effective anticancer therapy. Tumor microenvironment-induced nanomedicine size shrinkage is a promising strategy to overcome the drug penetration barrier across...

pH-Responsive dopamine-based nanoparticles assembled via Schiff base bonds for synergistic anticancer therapy

2020 ◽  
Vol 56 (87) ◽  
pp. 13347-13350
Author(s):  
Hong Li ◽  
Yuanyuan Zhao ◽  
Yi Jia ◽  
Gang Chen ◽  
Junxia Peng ◽  
...  
Keyword(s):  
Schiff Base ◽  
Photodynamic Therapy ◽  
Anticancer Therapy ◽  
Ph Responsive ◽  
Drug Nanocarriers

Dopamine-based nanoparticles are constructed via Schiff base bonds to serve as pH-responsive drug nanocarriers for combined photodynamic therapy and chemotherapy.

scholarly journals A novel donor–π–acceptor halochromic 2,6-distyrylnaphthalene chromophore: synthesis, photophysical properties and DFT studies

RSC Advances ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 168-176
Author(s):  
Farhad Panahi ◽  
Ali Mahmoodi ◽  
Sajjad Ghodrati ◽  
Fazlolah Eshghi
Keyword(s):  
White Light ◽  
Potential Application ◽  
High Performance ◽  
Light Emission ◽  
Photophysical Properties ◽  
White Light Emission ◽  
High Potential ◽  
Dft Studies ◽  
Ph Responsive

A new pH-responsive fluorescence chromophore with white light emission at pH = 3 was synthesized which has high potential application in the preparation of high-performance lighting devices.

A Tunable pH-Responsive Nanomaterials for Cancer Delivery

2013 ◽  
Vol 750-752 ◽  
pp. 1476-1479 ◽  
Author(s):  
Bin Liu ◽  
Guan Hui Gao ◽  
Peng Liu ◽  
Hu Qiang Yi ◽  
Wei Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Potential Application ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Positive Potential ◽  
Ph Values ◽  
Drugs In Blood ◽  
Poly Ethylene

In this paper, we successfully designed a pH-responsive micelles based on hybrid polypeptide copolymers of poly (L-lysine-4-Azepan-1-yl-butyric)-b-poly (ethylene glycol)-b-poly (L-lysine-Diisopropylamide)-b-poly (L-leucine) (PLL(A)-PEG-PLL(B)-PLLeu) for efficient drug delivery. This pH-responsive nanoparticles were able to response to different pH values (pH=6.8 and 5.5). In vitro, these nanoparticles exhibited a stable and evenly distributed approximately 51 nm, a slightly positive potential about 10.3 mv at pH 7.4, which were crucial for the circulation of drugs in blood. While size and potential were about 130 nm and 34.7 mv at pH 6.8, which were good for drugs in membrane. Furthermore, the loading capability of DOX was up to 11.3%, and the pH-responsive release efficiency reached to 68.3% at pH 5.5. The results indicated that these micelles had huge potential application in cancer delivery.

Smart pH-responsive and high doxorubicin loading nanodiamond for in vivo selective targeting, imaging, and enhancement of anticancer therapy

2016 ◽  
Vol 4 (29) ◽  
pp. 5046-5058 ◽  
Author(s):  
Lin Li ◽  
Lu Tian ◽  
Yongli Wang ◽  
Wenjing Zhao ◽  
Fangqin Cheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Anticancer Therapy ◽  
Effective Strategy ◽  
Ph Responsive ◽  
Selective Targeting ◽  
Delivery Platform

We introduce a simple and effective strategy to design a promising drug delivery platform for improving the biomedical applications of smart nanodiamond carriers.

Design of pH responsive clickable prodrugs applied to histone deacetylase inhibitors: A new strategy for anticancer therapy

2013 ◽  
Vol 85 (3) ◽  
pp. 862-872 ◽  
Author(s):  
Régis Delatouche ◽  
Iza Denis ◽  
Marion Grinda ◽  
Fatima El Bahhaj ◽  
Estelle Baucher ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Anticancer Therapy ◽  
Ph Responsive ◽  
New Strategy

scholarly journals Synthesis of silica–alginate nanoparticles and their potential application as pH-responsive drug carriers

2019 ◽  
Vol 91 (1) ◽  
pp. 11-20 ◽  
Author(s):  
Xin Fan ◽  
Roman C. Domszy ◽  
Naiping Hu ◽  
Arthur J. Yang ◽  
Jeff Yang ◽  
...  
Keyword(s):  
Potential Application ◽  
Drug Carriers ◽  
Ph Responsive

Multifunctional microspherical magnetic and pH responsive carriers for combination anticancer therapy engineered by droplet-based microfluidics

2017 ◽  
Vol 5 (22) ◽  
pp. 4097-4109 ◽  
Author(s):  
Shaheer Maher ◽  
Abel Santos ◽  
Tushar Kumeria ◽  
Gagandeep Kaur ◽  
Martin Lambert ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Porous Silicon ◽  
Anticancer Therapy ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Ph Sensitive Polymer ◽  
Bacterial Nanowires

Drug loaded luminescent porous silicon diatoms and magnetic bacterial nanowires were encapsulated within pH sensitive polymer forming biodegradable microcapsules using droplet-based microfluidics for targeting colorectal cancer.

Enzyme and pH-responsive nanovehicles for intracellular drug release and photodynamic therapy

2017 ◽  
Vol 41 (6) ◽  
pp. 2468-2478 ◽  
Author(s):  
Ting Zhang ◽  
Shiying Huang ◽  
Huiming Lin ◽  
Na An ◽  
Ruihan Tong ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Drug Release ◽  
Cancer Treatment ◽  
Potential Application ◽  
The Novel ◽  
Ph Responsive

An enzyme and pH-responsive nanocomposite was constructed for sensitive intracellular drug release and photodynamic therapy (PDT). The novel nanoplatforms provide the potential application in cancer treatment.

Sign in / Sign up

Export Citation Format

Share Document