The protective effect of hydroxytyrosol acetate against inflammation of vascular endothelial cells partly through the SIRT6-mediated PKM2 signaling pathway

2019 ◽  
Vol 10 (9) ◽  
pp. 5789-5803 ◽  
Author(s):  
Feng Yao ◽  
Guangde Yang ◽  
Yushan Xian ◽  
Guan Wang ◽  
Zihan Zheng ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Inflammatory Response ◽  
Protective Effect ◽  
Signaling Pathway ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Anti Inflammatory ◽  
Inflammatory Effect

HT-AC had anti-inflammatory effect in hypercholesterolemic mice and TNF-stimulated HUVECs. HT-AC inhibited the inflammatory response partly through the TNFRSF1A/SIRT6/PKM2-mediated signaling pathway.

scholarly journals LCC-09, a Novel Salicylanilide Derivative, Exerts Anti-Inflammatory Effect in Vascular Endothelial Cells

2021 ◽  
Vol Volume 14 ◽  
pp. 4551-4565
Author(s):  
Ramcharan Singh Angom ◽  
Jian Zhu ◽  
Alexander TH Wu ◽  
Maryam Rachmawati Sumitra ◽  
Victoria Pham ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Cordycepin Attenuates Palmitic Acid-Induced Inflammation and Apoptosis of Vascular Endothelial Cells through Mediating PI3K/Akt/eNOS Signaling Pathway

2021 ◽  
pp. 1-20
Author(s):  
Chang-Wen Ku ◽  
Tsung-Jung Ho ◽  
Chih-Yang Huang ◽  
Pei-Ming Chu ◽  
Hsiu-Chung Ou ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Palmitic Acid ◽  
Signaling Pathway ◽  
Inflammatory Responses ◽  
Vascular Endothelial Cells ◽  
Cordyceps Sinensis ◽  
Ros Generation ◽  
Vascular Endothelial ◽  
Protective Effects ◽  
Anti Inflammatory

A well-known medicinal mushroom in the field of traditional Chinese medicine, Cordyceps sinensis, is a rare natural-occurring entomopathogenic fungus, and it typically grows at high altitudes on the plateau of the Himalayan. Previous studies indicated that cordycepin, the main bioactive chemical of Cordyceps sinensis, has very potent anticancer, anti-oxidant and anti-inflammatory activities. However, its protective effects against atherosclerotic changes in vascular endothelial cells have not been fully elucidated. In this study, we showed that pretreatment with cordycepin significantly attenuated palmitic acid (PA)-induced cytotoxicity, reactive oxygen species (ROS) generation, and inflammatory responses. We found that PA decreased phosphorylation of Akt, eNOS, and bioavailability of nitric oxide (NO), which in turn activated NF-[Formula: see text]B and the downstream inflammatory responses. All these detrimental events were markedly blocked by pretreatment with cordycepin. Moreover, cordycepin ameliorated destabilization of mitochondrial permeability, cytosolic calcium rises, and apoptotic features caused by PA. In addition, all these anti-inflammatory and anti-apoptosis effects of cordycepin were found to be inhibited by the PI3K and eNOS inhibitor, suggesting that its anti-atherosclerotic effects may partially be mediated by the PI3K/Akt/eNOS signaling pathway.

scholarly journals Regulation of the inflammatory response of vascular endothelial cells by EPAC1

2012 ◽  
Vol 166 (2) ◽  
pp. 434-446 ◽  
Author(s):  
Euan Parnell ◽  
Brian O Smith ◽  
Timothy M Palmer ◽  
Anna Terrin ◽  
Manuela Zaccolo ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Inflammatory Response ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial

scholarly journals Protective effect of Melissa officinalis extract against H2O2-induced oxidative stress in human vascular endothelial cells

2016 ◽  
Vol 11 (5) ◽  
pp. 383 ◽  
Author(s):  
Leila Safaeian ◽  
SeyyedEbrahim Sajjadi ◽  
ShaghayeghHaghjooy Javanmard ◽  
Hossein Montazeri ◽  
Fariba Samani
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Protective Effect ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Melissa Officinalis
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