N-carbamylglutamate and l-arginine promote intestinal function in suckling lambs with intrauterine growth restriction by regulating antioxidant capacity via a nitric oxide-dependent pathway

2019 ◽  
Vol 10 (10) ◽  
pp. 6374-6384 ◽  
Author(s):  
Hao Zhang ◽  
Hua Sun ◽  
Along Peng ◽  
Shuang Guo ◽  
Mengzhi Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antioxidant Capacity ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intestinal Function ◽  
Intrauterine Growth ◽  
Dependent Pathway

Data indicate that intrauterine growth restriction (IUGR) in newborns can be partly alleviated through the supply of l-arginine (Arg) and N-carbamylglutamate (NCG).

Neurokinin B and nitric oxide plasma levels in pre-eclampsia and isolated intrauterine growth restriction

2004 ◽  
Vol 111 (10) ◽  
pp. 1046-1050 ◽  
Author(s):  
Rosario D'Anna ◽  
Giovanni Baviera ◽  
Francesco Corrado ◽  
Alessandra Crisafulli ◽  
Riccardo Ientile ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Plasma Levels ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Neurokinin B ◽  
Intrauterine Growth

Fetal nucleated red blood cells in a rat model of intrauterine growth restriction induced by hypoxia and nitric oxide synthase inhibition

2007 ◽  
Vol 196 (5) ◽  
pp. 482.e1-482.e8 ◽  
Author(s):  
Viswanathan Ravishankar ◽  
Catalin S. Buhimschi ◽  
Carmen J. Booth ◽  
Vineet Bhandari ◽  
Errol Norwitz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Red Blood Cells ◽  
Rat Model ◽  
Blood Cells ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Nucleated Red Blood Cells ◽  
Oxide Synthase

Effects of intrauterine growth restriction during late pregnancy on the ovine fetal renal function and antioxidant capacity

2021 ◽  
Vol 92 (1) ◽  
Author(s):  
Yang Zi ◽  
Chi Ma ◽  
Huimin Li ◽  
Suting Shen ◽  
Yingchun Liu ◽  
...  
Keyword(s):  
Renal Function ◽  
Antioxidant Capacity ◽  
Intrauterine Growth Restriction ◽  
Late Pregnancy ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Ovine Fetal

167: Intrauterine growth restriction increases nitric oxide synthase activity in the lungs of female but not male rats at birth

2012 ◽  
Vol 206 (1) ◽  
pp. S87-S88
Author(s):  
Daniel Malleske ◽  
Rajwinderjit Kaur ◽  
Xing Yu ◽  
Christopher Callaway ◽  
Robert McKnight ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Male Rats ◽  
Intrauterine Growth ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

Intrauterine growth restriction-induced deleterious adaptations in endothelial progenitor cells: possible mechanism to impair endothelial function

2017 ◽  
Vol 8 (6) ◽  
pp. 665-673 ◽  
Author(s):  
V. Oliveira ◽  
L. V. de Souza ◽  
T. Fernandes ◽  
S. D. S. Junior ◽  
M. H. C. de Carvalho ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Functional Capacity ◽  
Intrauterine Growth Restriction ◽  
Vascular Reactivity ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Ad Libitum

Intrauterine growth restriction (IUGR) can induce deleterious changes in the modulatory ability of the vascular endothelium, contributing to an increased risk of developing cardiovascular diseases in the long term. However, the mechanisms involved are not fully understood. Emerging evidence has suggested the potential role of endothelial progenitor cells (EPCs) in vascular health and repair. Therefore, we aimed to evaluate the effects of IUGR on vascular reactivity and EPCs derived from the peripheral blood (PB) and bone marrow (BM)in vitro. Pregnant Wistar rats were fed anad libitumdiet (control group) or 50% of thead libitumdiet (restricted group) throughout gestation. We determined vascular reactivity, nitric oxide (NO) concentration, and endothelial nitric oxide synthase (eNOS) protein expression by evaluating the thoracic aorta of adult male offspring from both groups (aged: 19–20 weeks). Moreover, the amount, functional capacity, and senescence of EPCs were assessedin vitro. Our results indicated that IUGR reduced vasodilation via acetylcholine in aorta rings, decreased NO levels, and increased eNOS phosphorylation at Thr495. The amount of EPCs was similar between both groups; however, IUGR decreased the functional capacity of EPCs from the PB and BM. Furthermore, the senescence process was accelerated in BM-derived EPCs from IUGR rats. In summary, our findings demonstrated the deleterious changes in EPCs from IUGR rats, such as reduced EPC function and accelerated senescencein vitro. These findings may contribute towards elucidating the possible mechanisms involved in endothelial dysfunction induced by fetal programming.

Nitric oxide synthase and changes in oxidative stress levels in embryonic kidney observed in a rabbit model of intrauterine growth restriction

2016 ◽  
Vol 36 (7) ◽  
pp. 628-635 ◽  
Author(s):  
Horacio Figueroa ◽  
Jorge Cifuentes ◽  
Mauricio Lozano ◽  
Cristobal Alvarado ◽  
Claudia Cabezas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Intrauterine Growth Restriction ◽  
Rabbit Model ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Stress Levels ◽  
Oxide Synthase

Amniotic levels of nitric oxide in women with fetal intrauterine growth restriction

2003 ◽  
Vol 13 (2) ◽  
pp. 115-118 ◽  
Author(s):  
A. L. Tranquilli ◽  
V. Bezzeccheri ◽  
S. R. Giannubilo ◽  
C. Scagnoli ◽  
L. Mazzanti ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth

Nitric oxide concentrations are increased in the feto-placental circulation in intrauterine growth restriction

Placenta ◽  
1996 ◽  
Vol 17 (2-3) ◽  
pp. 165-168 ◽  
Author(s):  
F. Lyall ◽  
I.A. Greer ◽  
A. Young ◽  
L. Myatt
Keyword(s):  
Nitric Oxide ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth
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