Direct visualization of drug release in injectable implant by laser induced breakdown spectroscopy (LIBS)

2019 ◽  
Vol 34 (7) ◽  
pp. 1351-1354 ◽  
Author(s):  
Lanfang Zou ◽  
Mallory J. Stenslik ◽  
Morgan B. Giles ◽  
James D. Ormes ◽  
Maureen Marsales ◽  
...  
Keyword(s):  
Drug Release ◽  
Laser Induced Breakdown Spectroscopy ◽  
Imaging Method ◽  
Direct Visualization ◽  
Release Process ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown ◽  
2D Imaging ◽  
Long Acting ◽  
First Time

A novel laser induced breakdown spectroscopy (LIBS) 2D imaging method is used to directly visualize the drug release process of long-acting injectable (LAI) implants for the first time.

A study of underwater stand-off laser-induced breakdown spectroscopy for chemical analysis of objects in the deep ocean

2015 ◽  
Vol 30 (5) ◽  
pp. 1050-1056 ◽  
Author(s):  
F. J. Fortes ◽  
S. Guirado ◽  
A. Metzinger ◽  
J. J. Laserna
Keyword(s):  
Chemical Analysis ◽  
Deep Ocean ◽  
Laser Induced Breakdown Spectroscopy ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown ◽  
Submerged Objects ◽  
First Time

In this work, we demonstrate for the first time the feasibility of stand-off laser induced breakdown spectroscopy (ST-LIBS) for the analysis of distant submerged objects.

scholarly journals Mg/Ca ratios measured by laser induced breakdown spectroscopy (LIBS): a new approach to decipher environmental conditions

2015 ◽  
Vol 30 (9) ◽  
pp. 1913-1919 ◽  
Author(s):  
A. García-Escárzaga ◽  
S. Moncayo ◽  
I. Gutiérrez-Zugasti ◽  
M. R. González-Morales ◽  
J. Martín-Chivelet ◽  
...  
Keyword(s):  
Environmental Conditions ◽  
Laser Induced Breakdown Spectroscopy ◽  
New Approach ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown ◽  
Mollusc Species ◽  
First Time ◽  
Environmental Proxy

Mg/Ca ratios in shells of the mollusc species Phorcus lineatus obtained using the LIBS technique has been evaluated as an environmental proxy to reconstruct paleotemperatures and season of capture of molluscs for the first time.

Multiplexing Steganography Based on Laser-Induced Breakdown Spectroscopy Coupled with Machine Learning

2021 ◽  
Author(s):  
Pengkun Yin ◽  
Enlai Yang ◽  
Youyuan Chen ◽  
Zhengying Peng ◽  
Dan Li ◽  
...  
Keyword(s):  
Machine Learning ◽  
Laser Induced Breakdown Spectroscopy ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown ◽  
First Time

This study proposed steganography based on laser-induced breakdown spectroscopy (LIBS) for the first time. LIBS inks containing different elements with varying concentrations were fabricated to write steganographic text. LIBS combined...

scholarly journals Standoff Detection of Explosives at 1 m using Laser Induced Breakdown Spectroscopy

2017 ◽  
Vol 67 (6) ◽  
pp. 623 ◽  
Author(s):  
Manoj Kumar Gundawar ◽  
Rajendhar Junjuri ◽  
Ashwin Kumar Myakalwar
Keyword(s):  
Electron Density ◽  
Plasma Temperature ◽  
Laser Induced Breakdown Spectroscopy ◽  
Stark Broadening ◽  
Breakdown Spectroscopy ◽  
Standoff Detection ◽  
Laser Induced Breakdown ◽  
Plasma Characteristics ◽  
Detection Of Explosives ◽  
First Time

<p class="p1">We report the ‘standoff detection’ of explosives at 1 m in laboratory conditions, for the first time in India, using Laser Induced Breakdown Spectroscopy combined with multivariate analysis. The spectra of a set of five secondary explosives were recorded at a distance of 1 m from the focusing as well as collection optics. The plasma characteristics viz., plasma temperature and electron density were estimated from Boltzmann statistics and Stark broadening respectively. Plasma temperature was estimated to be of the order of (10.9 ± 2.1) .103 K and electron density of (3.9 ± 0.5) .1016 cm-3. Using a ratiometric approach, C/H and H/O ratios showed a good correlation with the actual stoichiometric ratios and a partial identification success could be achieved. Finally employing principle component analysis, an excellent classification could be attained.<span class="Apple-converted-space"> </span></p>

Mapping of Uranium in Surrogate Nuclear Debris Using Laser-Induced Breakdown Spectroscopy (LIBS)

2019 ◽  
Vol 73 (6) ◽  
pp. 591-600 ◽  
Author(s):  
Michael B. Shattan ◽  
Mark Gragston ◽  
Zhili Zhang ◽  
John D. Auxier ◽  
Kathryn G. McIntosh ◽  
...  
Keyword(s):  
Matrix Effects ◽  
Atomic Emission ◽  
Laser Induced Breakdown Spectroscopy ◽  
Exterior Surface ◽  
Breakdown Spectroscopy ◽  
Melting Temperatures ◽  
Laser Induced Breakdown ◽  
Fractionation Pattern ◽  
Effective Instrument ◽  
First Time

This work describes the use of a laser-induced breakdown spectroscopy (LIBS) system to conduct macroscopic elemental mapping of uranium and iron on the exterior surface and interior center cross-section of surrogate nuclear debris for the first time. The results suggest that similar LIBS systems could be packaged for use as an effective instrument for screening samples during collection activities in the field or to conduct process control measurements during the production of debris surrogates. The technique focuses on the mitigation of chemical and physical matrix effects of four uranium atomic emission lines, relatively free of interferences and of good analytical value. At a spatial resolution of 0.5 mm, a material fractionation pattern in the surrogate debris is identified and discussed in terms of constituent melting temperatures and thermal gradients experienced.

In situ analytical characterization and chemical imaging of tablet coatings using laser induced breakdown spectroscopy (LIBS)

The Analyst ◽  
2018 ◽  
Vol 143 (20) ◽  
pp. 5000-5007 ◽  
Author(s):  
Lanfang Zou ◽  
Brittany Kassim ◽  
Joseph P. Smith ◽  
James D. Ormes ◽  
Yong Liu ◽  
...  
Keyword(s):  
Quantitative Evaluation ◽  
Imaging Technique ◽  
Chemical Imaging ◽  
Laser Induced Breakdown Spectroscopy ◽  
Direct Visualization ◽  
Analytical Characterization ◽  
Breakdown Spectroscopy ◽  
Coating Uniformity ◽  
Laser Induced Breakdown

The first report that describes direct visualization and quantitative evaluation of the coating uniformity using the LIBS-based 3D chemical imaging technique.

The effect of sample surface roughness on the microanalysis of microchip laser-induced breakdown spectroscopy

2020 ◽  
Vol 35 (2) ◽  
pp. 357-365
Author(s):  
Wei Wang ◽  
Lanxiang Sun ◽  
Guodong Wang ◽  
Peng Zhang ◽  
Lifeng Qi ◽  
...  
Keyword(s):  
Surface Roughness ◽  
Quantitative Analysis ◽  
Sample Surface ◽  
Microchip Laser ◽  
Laser Induced Breakdown Spectroscopy ◽  
Crater Diameter ◽  
Ablation Crater ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown ◽  
First Time

In the microanalysis of laser-induced breakdown spectroscopy, the influence of surface roughness on spectral stability and quantitative analysis capability was studied for the first time when the laser ablation crater diameter was approximately 10 μm.

scholarly journals Identification of Multiple Rare Earths and Other Associated Elements in Zircon by Laser-Induced Breakdown Spectroscopy

2020 ◽  
Vol 44 (1) ◽  
pp. 59-68
Author(s):  
AFMY Haider ◽  
Zulfiqar Hasan Khan
Keyword(s):  
Rare Earth ◽  
Rare Earth Elements ◽  
Laser Induced Breakdown Spectroscopy ◽  
Breakdown Spectroscopy ◽  
Natural Zircon ◽  
Laser Induced Breakdown ◽  
Beach Sands ◽  
Academy Of Sciences ◽  
First Time ◽  
Zircon Mineral

Laser-induced breakdown spectroscopy (LIBS), which is a powerful technique for the detection of minor and trace elements in a sample, has been used to analyze the enriched zircon mineral collected from the beach sands of southern Bangladesh. In addition to zirconium, a large number of rare earth elements viz. cerium, lanthanum, praseodymium, neodymium, ytterbium, gadolinium, dysprosium, erbium, samarium, europium, holmium and yttrium and other associated elements like hafnium, niobium, tantalum, magnesium, calcium, sodium, titanium and iron along with non-metals like phosphorus and silicon were detected in the enriched zircon samples by the LIBS technique. To the best of our knowledge, this is the first time that multiple rare earth elements have been identified in natural zircon by LIBS. Journal of Bangladesh Academy of Sciences, Vol. 44, No. 1, 59-68, 2020

Nanosecond laser-induced breakdown assisted by femtosecond laser pre-ionization in air: the effect on spatial resolution and continuous radiation

2020 ◽  
Vol 92 (2) ◽  
pp. 20701
Author(s):  
Bo Li ◽  
Xiaofeng Li ◽  
Zhifeng Zhu ◽  
Qiang Gao
Keyword(s):  
Femtosecond Laser ◽  
Spatial Resolution ◽  
Laser Induced Breakdown Spectroscopy ◽  
Nanosecond Laser ◽  
Breakdown Threshold ◽  
Powerful Technique ◽  
Breakdown Spectroscopy ◽  
Continuous Radiation ◽  
Laser Induced Breakdown

Laser-induced breakdown spectroscopy (LIBS) is a powerful technique for quantitative diagnostics of gases. The spatial resolution of LIBS, however, is limited by the volume of plasma. Here femtosecond-nanosecond dual-pulsed LIBS was demonstrated. Using this method, the breakdown threshold was reduced by 80%, and decay of continuous radiation was shortened. In addition, the volume of the plasma was shrunk by 85% and hence, the spatial resolution of LIBS was significantly improved.

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