Annulated bacteriochlorins for near-infrared photophysical studies

2019 ◽  
Vol 43 (19) ◽  
pp. 7209-7232 ◽  
Author(s):  
Hikaru Fujita ◽  
Haoyu Jing ◽  
Michael Krayer ◽  
Srinivasarao Allu ◽  
Gorre Veeraraghavaiah ◽  
...  
Keyword(s):  
Excited State ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Photophysical Studies ◽  
Excited State Lifetimes

Bacteriochlorins with phenaleno or benzo annulation absorb at 913 or 1033 nm and exhibit excited-state lifetimes of 150 or 7 ps, suggesting applications in photoacoustic imaging.

Making the Best Use of Excited-State Energy: Multimodality Theranostic Systems Based on NIR-II AIEgens

2020 ◽  
Author(s):  
Wenhan XU ◽  
Zhijun Zhang ◽  
Miaomiao Kang ◽  
Heng Guo ◽  
Youmei Li ◽  
...  
Keyword(s):  
Excited State ◽  
Near Infrared ◽  
State Energy ◽  
Photoacoustic Imaging ◽  
Basic Research ◽  
Great Promise ◽  
Ros Generation ◽  
Tumoricidal Activity ◽  
Excited State Energy ◽  
Multiple Imaging

A single-component multi-modal theranostic platform taking advantage of multiple imaging and therapy techniques may offer improved diagnostic monitoring capabilities and therapeutic efficacies. In this study, through structural tuning, a novel theranostic agent TSSAM with aggregation-induced emission (AIE) characteristics, bright second near-infrared (NIR-II) emission, high reactive oxygen species (ROS) generation capability and excellent photothermal conversion efficiency (40.1%) was developed. TSSAM makes the best use of its excited state energy and keeps perfect equilibrium between radiative and non-radiative transition to satisfy the needs of both NIR-II fluorescence imaging (FLI)/photoacoustic imaging (PAI)/photothermal imaging (PTI) trimodal imaging and photodynamic therapy (PDT)/photothermal therapy (PTT) synergistic therapy. Further experiments validated the superior imaging quality and tumoricidal activity of TSSAM, in which tumor tissues were completely eradicated and tumor metastasis was effectively inhibited by merely single injection and one-time laser irradiation. This research has therefore presented a smart multifunctional material holding great promise in both basic research and clinical practice.

Making the Best Use of Excited-State Energy: Multimodality Theranostic Systems Based on NIR-II AIEgens

2020 ◽  
Author(s):  
Wenhan XU ◽  
Zhijun Zhang ◽  
Miaomiao Kang ◽  
Heng Guo ◽  
Youmei Li ◽  
...  
Keyword(s):  
Excited State ◽  
Near Infrared ◽  
State Energy ◽  
Photoacoustic Imaging ◽  
Basic Research ◽  
Great Promise ◽  
Ros Generation ◽  
Tumoricidal Activity ◽  
Excited State Energy ◽  
Multiple Imaging

A single-component multi-modal theranostic platform taking advantage of multiple imaging and therapy techniques may offer improved diagnostic monitoring capabilities and therapeutic efficacies. In this study, through structural tuning, a novel theranostic agent TSSAM with aggregation-induced emission (AIE) characteristics, bright second near-infrared (NIR-II) emission, high reactive oxygen species (ROS) generation capability and excellent photothermal conversion efficiency (40.1%) was developed. TSSAM makes the best use of its excited state energy and keeps perfect equilibrium between radiative and non-radiative transition to satisfy the needs of both NIR-II fluorescence imaging (FLI)/photoacoustic imaging (PAI)/photothermal imaging (PTI) trimodal imaging and photodynamic therapy (PDT)/photothermal therapy (PTT) synergistic therapy. Further experiments validated the superior imaging quality and tumoricidal activity of TSSAM, in which tumor tissues were completely eradicated and tumor metastasis was effectively inhibited by merely single injection and one-time laser irradiation. This research has therefore presented a smart multifunctional material holding great promise in both basic research and clinical practice.

Near-Infrared Emitting Heterobinuclear Zn-Ln (Ln = Nd, Yb, Er,and Gd) Complexes Based on a Novel Asymmetric Schiff-Base Ligand

2013 ◽  
Vol 749 ◽  
pp. 527-532
Author(s):  
Shun Sheng Zhao
Keyword(s):  
Schiff Base ◽  
Excited State ◽  
Schiff Base Ligand ◽  
Near Infrared ◽  
Zinc Complex ◽  
Intramolecular Energy Transfer ◽  
Elementary Analysis ◽  
Ft Ir ◽  
Photophysical Studies ◽  
Nir Luminescence

With the asymmetric Schiff-base zinc complex ZnL (H2L = N-(5-bromo-3-methoxysalicylidene)-N'-(5-(4-cyanophenyl)-3-methoxysalicylidene) phenylene-1,2-diamine) as the precursor, a series of heterobinuclear Zn-Ln complexes [ZnLnL(NO3)3(CH3CN)] (Ln = Nd, 1; Ln = Yb, 2; Ln = Er, 3; Ln = Gd, 4) are synthesized by the further reaction with Ln (NO3)3·6H2O, and characterized by FT-IR, FAB-MS and elementary analysis. Photophysical studies of these complexes show that the strong and characteristic NIR luminescence of Nd3+, Yb3+and Er3+ with emissive lifetimes in the microsecond range has been sensitized from the excited state of the asymmetric Schiff-base ligand due to effective intramolecular energy transfer.

Pyrazino[2,3-g]quinoxaline-Based Nanoparticles as Near-Infrared Phototheranostic Agents for Efficient Photoacoustic-Imaging-Guided Photothermal Therapy

2021 ◽  
Vol 4 (2) ◽  
pp. 2019-2029
Author(s):  
Li-Peng Zhang ◽  
Lin Kang ◽  
Xianqiang Li ◽  
Shiyang Liu ◽  
Tianlong Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging

scholarly journals Realizing Near‐Infrared Laser Dyes through a Shift in Excited‐State Absorption

2021 ◽  
pp. 2001947
Author(s):  
Reiko Aoki ◽  
Ryutaro Komatsu ◽  
Kenichi Goushi ◽  
Masashi Mamada ◽  
Soo Young Ko ◽  
...  
Keyword(s):  
Excited State ◽  
Near Infrared ◽  
Excited State Absorption ◽  
Infrared Laser ◽  
Laser Dyes

Ambient Oxygen-Doped Conjugated Polymer for pH-Activatable Aggregation-Enhanced Photoacoustic Imaging in the Second Near-Infrared Window

2021 ◽  
Vol 93 (6) ◽  
pp. 3189-3195
Author(s):  
Jiayingzi Wu ◽  
Liyan You ◽  
Saadia T. Chaudhry ◽  
Jiazhi He ◽  
Ji-Xin Cheng ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Ambient Oxygen ◽  
Infrared Window

Near-Infrared Combination and Overtone Bands of CH in CHX3, CHX2—CHX2, and CHX2—CX2—CHX2

2005 ◽  
Vol 59 (11) ◽  
pp. 1393-1398 ◽  
Author(s):  
Reikichi Iwamoto ◽  
Akishi Nara ◽  
Toshihiko Matsuda
Keyword(s):  
Excited State ◽  
Near Infrared ◽  
Present Report ◽  
Spectral Characteristics ◽  
The Other ◽  
Coupled Modes ◽  
Third Order ◽  
The Third ◽  
Combination Bands ◽  
Deformation Modes

In the present report we studied spectral characteristics of the near-infrared combination and overtone bands of CH vibrations of a CH sequence. The near-infrared bands of the CH in CHX3 (X, halogen), which were interpreted in terms of the CH stretching and CH deformation fundamentals without any ambiguity, typically showed how the frequency and intensity of a combination or an overtone depend on the vibrational excited state. In the CH–C–CH of CHX2CX2CHX2, the vibrations of one CH are isolated from those of the other CH, and the combination and overtone bands were similarly interpreted as those of the CH, although each of the combination bands was split into two because of non-degeneracy of the CH deformation. In the CH–CH of CHX2CHX2, the CH deformations only have coupled modes. The first combination showed four narrowly separate bands, which were reasonably interpreted on the basis of the CH stretching and the coupled CH deformation modes. We demonstrated that the first combination of coupled modes as well as the combination of up to, at least, the third order of isolated modes have the nature of the characteristic bands.

scholarly journals Recent advances in applications of multimodal ultrasound-guided photoacoustic imaging technology

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Shanshan Wang ◽  
Yunfeng Zhao ◽  
Ye Xu
Keyword(s):  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Imaging Techniques ◽  
Color Doppler ◽  
Power Doppler ◽  
Infrared Region ◽  
Detection Methods ◽  
Imaging Mode ◽  
Nonlinear Imaging ◽  
The Relationship

Abstract Photoacoustic imaging (PAI) is often performed simultaneously with ultrasound imaging and can provide functional and cellular information regarding the tissues in the anatomical markers of the imaging. This paper describes in detail the basic principles of photoacoustic/ultrasound (PA/US) imaging and its application in recent years. It includes near-infrared-region PA, photothermal, photodynamic, and multimode imaging techniques. Particular attention is given to the relationship between PAI and ultrasonic imaging; the latest high-frequency PA/US imaging of small animals, which involves not only B-mode, but also color Doppler mode, power Doppler mode, and nonlinear imaging mode; the ultrasonic model combined with PAI, including the formation of multimodal imaging; the preclinical imaging methods; and the most effective detection methods for clinical research for the future.

Sign in / Sign up

Export Citation Format

Share Document