scholarly journals Ultrabright fluorescent silica nanoparticles for in vivo targeting of xenografted human tumors and cancer cells in zebrafish

Nanoscale ◽  
2019 ◽  
Vol 11 (46) ◽  
pp. 22316-22327 ◽  
Author(s):  
Saquib Ahmed M. A. Peerzade ◽  
Xiaodan Qin ◽  
Fabrice J. F. Laroche ◽  
Shajesh Palantavida ◽  
Maxim Dokukin ◽  
...  

New ultrabright fluorescent silica nanoparticles for targeting cancers in vivo are presented.

Author(s):  
Xiaodan Qin ◽  
Fabrice F. J. Laroche ◽  
Saquib Ahmed M. A. Peerzade ◽  
Andrew Lam ◽  
Igor Sokolov ◽  
...  

Nanomaterials ◽  
2016 ◽  
Vol 6 (5) ◽  
pp. 81 ◽  
Author(s):  
Wen-Han Zhang ◽  
Xiao-Xiao Hu ◽  
Xiao-Bing Zhang

2010 ◽  
Vol 299 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Young-Seok Cho ◽  
Tae-Jong Yoon ◽  
Eue-Soon Jang ◽  
Kwan Soo Hong ◽  
Shin Young Lee ◽  
...  

2009 ◽  
Vol 12 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Yong Hyun Jeon ◽  
Young-Hwa Kim ◽  
Kihwan Choi ◽  
Jing Yu Piao ◽  
Bo Quan ◽  
...  

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2892
Author(s):  
Stefan Franco ◽  
Achraf Noureddine ◽  
Jimin Guo ◽  
Jane Keth ◽  
Michael L. Paffett ◽  
...  

Macrophages line the walls of microvasculature, extending processes into the blood flow to capture foreign invaders, including nano-scale materials. Using mesoporous silica nanoparticles (MSNs) as a model nano-scale system, we show the interplay between macrophages and MSNs from initial uptake to intercellular trafficking to neighboring cells along microtubules. The nature of cytoplasmic bridges between cells and their role in the cell-to-cell transfer of nano-scale materials is examined, as is the ability of macrophages to function as carriers of nanomaterials to cancer cells. Both direct administration of nanoparticles and adoptive transfer of nanoparticle-loaded splenocytes in mice resulted in abundant localization of nanomaterials within macrophages 24 h post-injection, predominately in the liver. While heterotypic, trans-species nanomaterial transfer from murine macrophages to human HeLa cervical cancer cells or A549 lung cancer cells was robust, transfer to syngeneic 4T1 breast cancer cells was not detected in vitro or in vivo. Cellular connections and nanomaterial transfer in vivo were rich among immune cells, facilitating coordinated immune responses.


2015 ◽  
Vol 3 (7) ◽  
pp. 1245-1253 ◽  
Author(s):  
Yu Gao ◽  
Yaqi Wang ◽  
Afu Fu ◽  
Wei Shi ◽  
David Yeo ◽  
...  

Core–shell fluorescent silica nanoparticles for in vitro and in vivo tracking of tumor tropism of human mesenchymal stem cells.


RSC Advances ◽  
2018 ◽  
Vol 8 (39) ◽  
pp. 21679-21689 ◽  
Author(s):  
Denisa Lizoňová ◽  
Monika Majerská ◽  
Vlastimil Král ◽  
Michal Pechar ◽  
Robert Pola ◽  
...  

Nanoparticles functionalised with pHPMA and monoclonal antibody IgG M75 show specific adhesion to tumour cells expressing carbonic anhydrase IX bothin vitroandin vivo.


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