scholarly journals Brushing the surface: cascade reactions between immobilized nanoreactors

Nanoscale ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 1551-1562 ◽  
Author(s):  
Dalin Wu ◽  
Serena Rigo ◽  
Stefano Di Leone ◽  
Andrea Belluati ◽  
Edwin C. Constable ◽  
...  
Keyword(s):  
Polymer Brushes ◽  
Cascade Reactions ◽  
Cascade Reaction

A tandem cascade reaction between polymer brushes-supported nanoreactors has been demonstrated.

scholarly journals Synthesis of spiro[benzo[4,5]imidazo[2,1-b][1,3]thiazole-2,3-thiolane]s via sulfa-Michael/aldol cascade reactions

2019 ◽  
Vol 43 (1-2) ◽  
pp. 63-66 ◽  
Author(s):  
Jiaying Lei ◽  
Xinliang Fu ◽  
Yulin Huang ◽  
Xiaofang Li
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Crystallographic Analysis ◽  
X Ray ◽  
Resolution Mass

The sulfa-Michael/aldol cascade reaction of ( Z)-2-arylmethylidene-benzo[4,5]imidazo[2,1- b]thiazol-3(2H)-ones and 1,4-dithiane-2,5-diol afforded novel 2-aryl-4-hydroxy-spiro[benzo[4,5]imidazo[2,1- b][1,3]thiazole-2,3-thiolan]-3-ones in moderate yields. The structures of all the products were characterized thoroughly by nuclear magnetic resonance, infrared and high-resolution mass spectrometry together with X-ray crystallographic analysis.

Diversity-Oriented Synthesis of Natural Products via Gold-Catalyzed Cascade Reactions

Synlett ◽  
2018 ◽  
Vol 29 (12) ◽  
pp. 1552-1571 ◽  
Author(s):  
Jianxian Gong ◽  
Zhen Yang ◽  
Yueqing Gu ◽  
Ceheng Tan
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Biologically Active ◽  
Synthetic Methods ◽  
Left Wing ◽  
Asymmetric Total Synthesis ◽  
Diversity Oriented Synthesis ◽  
Active Natural

This account describes our group’s latest research in the field of diversity-oriented synthesis of natural products via gold-catalyzed cascade reactions. We present two general strategies based on gold-catalyzed cycloisomerization: a gold-catalyzed cascade reaction of 1,7-diynes and a pinacol-terminated gold-catalyzed cascade reaction. We highlight our development of synthetic methods for the construction of biologically active natural products by using these two strategies.1 Introduction2 Gold-Catalyzed Cascade Reactions of 1,7-Diynes2.1 Collective Synthesis of C15 Oxygenated Drimane-Type Sesquiterpenoids2.2 Synthesis of Left-Wing Fragment of Azadirachtin I2.3 Collective Synthesis of Cladiellins3 Pinacol-Terminated Gold-Catalyzed Cascade Reaction3.1 Asymmetric Formal Total Synthesis of (+)-Cortistatins3.2 Total Synthesis of Orientalol F3.3 Asymmetric Total Synthesis of (–)-Farnesiferol C4 Summary and Outlook

scholarly journals Synthesis of indanes via carbene-catalyzed single-electron-transfer processes and cascade reactions

2017 ◽  
Vol 53 (87) ◽  
pp. 11952-11955 ◽  
Author(s):  
Yuhuang Wang ◽  
Xingxing Wu ◽  
Yonggui Robin Chi
Keyword(s):  
Electron Transfer ◽  
Michael Addition ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Single Electron ◽  
Single Electron Transfer ◽  
Transfer Processes ◽  
Electron Transfer Processes

An NHC-catalyzed cascade reaction involving an SET process and two sequential Michael addition steps for the synthesis of indanes is disclosed.

Double enzymatic cascade reactions within FeSe–Pt@SiO2 nanospheres: synthesis and application toward colorimetric biosensing of H2O2 and glucose

The Analyst ◽  
2015 ◽  
Vol 140 (19) ◽  
pp. 6684-6691 ◽  
Author(s):  
Fengmin Qiao ◽  
Zhenzhen Wang ◽  
Ke Xu ◽  
Shiyun Ai
Keyword(s):  
Colorimetric Detection ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Peroxidase Mimic ◽  
Colorimetric Biosensing

The FeSe–Pt@SiO2 nanospheres possessed both intrinsic GOx- and peroxidase-mimic activities, which realized colorimetric detection of glucose through a cascade reaction.

Metal-free multicomponent cascade reactions of homopropargylic amines and acyl chlorides as well as potassium thiocyanate and diiodine: an access to thiazine imides

2018 ◽  
Vol 16 (33) ◽  
pp. 5955-5959
Author(s):  
Jing Wu ◽  
Yuanfang Kong ◽  
Lingyan Liu ◽  
Weixing Chang ◽  
Jing Li
Keyword(s):  
Potassium Thiocyanate ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Acyl Chlorides ◽  
Metal Free

A novel metal-free multicomponent cascade reaction was developed for the construction of thiazine imides.

scholarly journals Heterogeneous Synergistic Catalysis for Promoting Aza-Michael–Henry Tandem Reaction for the Synthesis of Chiral 3-Nitro-1,2-Dihydroquinoline

Catalysts ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 713 ◽  
Author(s):  
Zhe An ◽  
Lifeng Chen ◽  
Yitao Jiang ◽  
Jing He
Keyword(s):  
Secondary Amine ◽  
Tertiary Amine ◽  
Enantiomeric Excess ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Tandem Reaction ◽  
Chiral Amines ◽  
Synergistic Catalysis ◽  
Geometrical Constraints ◽  
Synergistic Mechanism

Heterogeneous synergistic catalysis by SBA-15 immobilized chiral amines catalysts has promoted efficient aza-Michael–Henry tandem reaction for the synthesis of chiral 3-Nitro-1,2-Dihydroquinoline. Final products in the asymmetric aza-Michael–Henry cascade reactions between 2-aminobenzaldehyde and β-nitrostyrolene were afforded in a yield of 85% and an enantiomeric excess (ee) value of 98% on (S)-(–)-2-aminomethyl-1-ethylpyrrolidine immobilized SBA-15. SBA-15-AEP catalyst has been also extended to the asymmetric aza-Michael–Henry cascade reaction of substituted R1-2-aminobenzaldehyde and R2-substituted nitroolefin. The heterogeneous synergistic mechanism for both tertiary amine and secondary amine immobilized mesoporous has been proposed in detail including the geometrical constraints in the ee promotion.

Synthesis of γ,δ-Unsaturated Esters and Amides via Au(I)-Catalyzed Reactions of Aryl Ynol Ethers or Ynamides with Allylic Alcohols

Synthesis ◽  
2021 ◽  
Author(s):  
Souta Misawa ◽  
Asaki Miyairi ◽  
Yoshihiro Oonishi ◽  
Steven P. Nolan ◽  
Yoshihiro Sato
Keyword(s):  
Claisen Rearrangement ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Allylic Alcohols ◽  
Unsaturated Esters ◽  
Mild Conditions ◽  
Reaction Proceeds ◽  
Ynol Ethers ◽  
Catalyzed Reactions ◽  
Reaction Attack

Polarized alkynes such as ynol ethers and ynamides have attracted much attention due to their inherent unique reactivity. Herein, we report Au(I)-catalyzed hydroalkoxylation/Claisen rearrangement cascade reactions of aryl ynol ethers and ynamides with allylic alcohols. At the first stage (hydroalkoxylation) of this cascade reaction, attack of allylic alcohols to aryl ynol ethers or ynamides occurs at the α-position of the polarized alkynes in an entirely regioselective manner. Claisen rearrangement of the resulting adducts subsequentially takes place to give γ,δ-unsaturated esters or amides, respectively. The [Au(IPr)NTf2] catalyst is most effective for this reaction, and the reaction proceeds under mild conditions (in the case of aryl ynol ether: in THF, 60 °C; in the case of ynamides: in toluene, 80 °C) in an atom-economical way.

Visible-light organic photoredox catalytic cascade reaction

2021 ◽  
Author(s):  
Guo-Qiang Xu ◽  
Peng-Fei Xu
Keyword(s):  
Transition Metals ◽  
Visible Light ◽  
Visible Light Irradiation ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Light Irradiation ◽  
The Past

Over the past years, impressive progress has been made on the development of organic photoredox catalytic cascade reactions without the participation of expensive and toxic transition-metals under visible light irradiation....

Synthesis of Spiro Indazole-Tetrahydrothiophenes via Sulfa-Michael/Aldol Cascade Reactions

2017 ◽  
Vol 41 (11) ◽  
pp. 641-644 ◽  
Author(s):  
Shaowei Zhang ◽  
Demin Ren ◽  
Xiaolian Hu ◽  
Xingliang Fu ◽  
Xiaofang Li
Keyword(s):  
Cascade Reactions ◽  
Cascade Reaction ◽  
Crystallographic Analysis ◽  
X Ray

The sulfa-Michael/aldol cascade reaction of 5-arylmethylidene-1-phenyl-6,7-dihydro-1H-indazol-4(5H)-ones and 1,4-dithiane-2,5-diol yielded novel 2′-(4-aryl)-4′-hydroxy-1-phenyl-4′,5′,6,7-tetrahydro-2′H-spiro[indazole-5,3′-thiophen]-4(1H)-ones in moderate yields. The structures of all the products were characterised thoroughly by NMR, IR and HRMS, together with X-ray crystallographic analysis.

Squaramide-catalysed asymmetric cascade reactions of 2,3-dioxopyrrolidines with 3-chlorooxindoles

2020 ◽  
Vol 18 (8) ◽  
pp. 1647-1656 ◽  
Author(s):  
Jiang-Bo Wen ◽  
Da-Ming Du
Keyword(s):  
Michael Addition ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Spiro Compounds ◽  
Asymmetric Michael Addition ◽  
High Yields

An efficient squaramide-catalysed asymmetric Michael addition/cyclization cascade reaction of 3-chlorooxindoles with 2,3-dioxopyrrolidines produced the corresponding chiral spiro-compounds in high yields with excellent stereoselectivities.

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