scholarly journals Silver derivatives of multi-donor heterocyclic thioamides as antimicrobial/anticancer agents: unusual bio-activity against methicillin resistantS. aureus,S. epidermidis, andE. faecalisand human bone cancerMG63cell line

RSC Advances ◽  
2019 ◽  
Vol 9 (27) ◽  
pp. 15470-15487 ◽  
Author(s):  
Jaspreet K. Aulakh ◽  
Tarlok S. Lobana ◽  
Henna Sood ◽  
Daljit S. Arora ◽  
Raminderjit Kaur ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Anticancer Agents ◽  
Mixed Ligand ◽  
Human Bone ◽  
Mixed Ligand Complexes ◽  
Line P ◽  
Derivatives Of ◽  
Heterocyclic Thioamides

A series of biosafe mixed-ligand complexes of silver with heterocyclic thioamides have been studied for their antimicrobial/anticancer activity.

scholarly journals A One-Pot Three-Component Synthesis and Investigation of the In Vitro Mechanistic Anticancer Activity of Highly Functionalized Spirooxindole-Pyrrolidine Heterocyclic Hybrids

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5581
Author(s):  
Raju Suresh Kumar ◽  
Dhaifallah M. Al-thamili ◽  
Abdulrahman I. Almansour ◽  
Natarajan Arumugam ◽  
Faruq Mohammad
Keyword(s):  
Anticancer Activity ◽  
Anticancer Agents ◽  
One Pot ◽  
Major Pathway ◽  
Molecular Scaffold ◽  
Highly Active ◽  
Ft Ir ◽  
Derivatives Of ◽  
Unique Mechanism

With an aim to develop more effective and affordable anticancer agents possessing a unique mechanism of action, we designed and synthesized derivatives of spirooxindole-pyrrolidine heterocyclic hybrids in good yields through a one-pot three-component (3+2) cycloaddition strategy. The synthesized compounds were characterized thoroughly for the physicochemical properties by making use of FT-IR, NMR spectroscopy, and mass spectrometry. Further, these compounds have been evaluated for the influence of anticancer activity against HepG2 cells up to 200 µg/mL concentration. The highly active molecular scaffold was tested for the in-depth mechanistic studies, and it was found that the major pathway of cell death is apoptosis which occurs through the induction of reactive oxygen species followed by the involvement of caspases.

scholarly journals Synthesis, Structure, and Anticancerous Properties of Silver Complexes

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Shraddha Shukla ◽  
A. P. Mishra
Keyword(s):  
Anticancer Activity ◽  
Tumor Cells ◽  
Cancer Cell ◽  
Cell Biology ◽  
Sequence Data ◽  
Analysis Data ◽  
Mixed Ligand ◽  
Water Soluble ◽  
Mixed Ligand Complexes ◽  
Elemental Analysis Data

Although the “war on cancer” is now in its fourth decade and much progress has been made in categorizing the environmental causes and cellular and molecular biological basis for this dreaded disease, we still do not have a precise understanding of the differences between a cancer cell and its normal counterpart. The completion of the human genome sequence and its subsequent improvements in the sequence data are important steps to fully comprehend cancer cell biology. Ag(I) is being used as an anticancer agent in several human cancers. The anticancer activity of these complexes againstEhrlich’s ascitestumor cells (EACs) has been reported. The aim of the present study is to synthesize some new water soluble Ag(I) mixed ligand complexes containing nitrogen and sulfur base and to evaluate their biomedicinal properties. Mixed ligand complexes of Ag(I) metal derived from L-lysine and thiouracil with 2,2′-bipyridyl; 2-aminopyridine with thiouracil have been synthesized. The composition of the prepared complexes was discussed on the basis of microanalysis, FAB-mass, and FT-ir, measurements. Molecular weight was confirmed by FAB-mass spectra. The elemental analysis data suggest the stoichiometry to be M : L : L′ (1 : 1 : 1) ratio. These Ag(I) mixed ligand complexes showed excellent anticancer activity againstEhrlich’s ascitestumor cells (EACs).

Fully Fluorinated Alkoxides. Part VI. Derivatives of Hydroxyhexafluoroisobutyric Acid

1972 ◽  
Vol 50 (6) ◽  
pp. 939-945 ◽  
Author(s):  
J. T. Price ◽  
A. J. Tomlinson ◽  
C. J. Willis
Keyword(s):  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Tridentate Ligand ◽  
Phosphorus Containing ◽  
Fluorinated Alkoxides ◽  
Derivatives Of ◽  
Spectrochemical Series

Hydroxyhexafluoroisobutyric acid, HOC(CF3)2COOH, H2(HHIB), gives complexes with a variety of metals, acting as a chelating, dinegative ligand. Derivatives prepared include [B(HHIB)2]−, [M(HHIB)2]2− (M = Ni, Cu, Co), [M(HHIB)3]3− (M = Al, Cr, Mn, Fe), and mixed ligand complexes of Cu and Ni with HHIB and nitrogen- or phosphorus-containing ligands. In some cases, the HHIB anion appears to act as a tridentate ligand through carboxylate bridging. HHIB is close to water in the spectrochemical series.

Synthesis and Spectroscopic, Thermal and Electrochemical Studies of Mixed-ligand Complexes of Silver(I) with Derivatives of Benzoyltrifluoroacetonate and 4,4ʹ-Bipyridine, Including the Crystal Structure of [Ag(4,4ʹ-bpy)(tfcpb)]n

2012 ◽  
Vol 67 (5) ◽  
pp. 465-472 ◽  
Author(s):  
Farzin Marandi ◽  
Afsaneh Marandi ◽  
Ingo Pantenburg ◽  
Gerd Meyer
Keyword(s):  
Crystal Structure ◽  
Nmr Spectroscopy ◽  
Weak Interactions ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Electrochemical Studies ◽  
One Dimensional ◽  
H Nmr ◽  
Elemental Analyses ◽  
Derivatives Of

Three new mixed-ligand complexes of silver(I) with 4,4ʹ-bipyridine and derivates of benzoyltrifluoroacetone (Htfpb: 4,4,4-trifluoro-1-phenyl-1,3-butandione, Htfcpb: 4,4,4-trifluoro-1-(4- chlorophenyl)-1,3-butandione and Htfmpb: 4,4,4-trifluoro-1-(4-methoxyphenyl)-1,3-butandione) were synthesized and characterized by elemental analyses and 1H NMR spectroscopy. Thermal and electrochemical properties were also studied. The single-crystal structure of [Ag(4,4ʹ-bpy)(tfcpb)]n shows a one-dimensional coordination polymer as a result of 4,4ʹ-bpy bridging. The four-coordinate Ag(I) ions are linked into double chains by Ag...O contacts, which are extended into a 3D supramolecular structure through abundant weak interactions, such as μ...μ, C-H...F, C-H...O, C-H...Cl and F...F contacts.

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