Promoting antitumor efficacy by suppressing hypoxia via nano self-assembly of two irinotecan-based dual drug conjugates having a HIF-1α inhibitor

2019 ◽  
Vol 7 (35) ◽  
pp. 5352-5362 ◽  
Author(s):  
Bin Zhang ◽  
Xiaochao Huang ◽  
Hengshan Wang ◽  
Shaohua Gou
Keyword(s):  
Anticancer Drug ◽  
Self Assembly ◽  
Tumor Tissue ◽  
Delivery Systems ◽  
Molecular Entity ◽  
Nanodrug Delivery ◽  
Drug Conjugates ◽  
Hypoxic Tumor ◽  
Insight Into ◽  
Dual Drug

Conjugated a hydrophobic HIF-1α inhibitor (YC-1) with a hydrophilic anticancer drug, irinotecan (Ir), into one molecular entity, provided a new insight into the design of smart nanodrug delivery systems to hypoxic tumor tissue.

Cancer Nanotechnology-An Excursion on Drug Delivery Systems

2019 ◽  
Vol 18 (15) ◽  
pp. 2078-2092 ◽  
Author(s):  
Mala Sharma ◽  
Chitranshu Pandey ◽  
Neha Sharma ◽  
Mohammad A. Kamal ◽  
Usman Sayeed ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Cancer Chemoprevention ◽  
Delivery Systems ◽  
Nanostructured Lipid Carrier ◽  
Nanodrug Delivery ◽  
Drug Conjugates ◽  
Drug Nanoparticles ◽  
Cancer Nanotechnology

Background: Nanotechnology pictures a breakthrough in the domain of cancer therapy owing to its novel properties and functions. This technology is quite amendable as it allows the scientists to engineer drug nanoparticles of dimensions 10nm – 500nm permitting them to pass via leaky vasculature of tumorigenic microenvironment with higher specificity, reduced cytotoxicity and effective release without any after effects. The central part of the review zooms onto the role of nanoparticles and their targeted delivery for the cure of cancer. Methods: The novel and various versatile nanoparticle platforms viz. polymeric (drug-conjugates, micelles, dendrimers), Lipid-based (liposomes, solid nanoparticle, nanostructured lipid carrier, lipid-polymer hybrid), and stimuli-sensitive (thermoresponsive, ultrasound, pH-responsive, hydrogel) etc. have been designed for a persistent, précised nanodrug delivery and the co-delivery of collegial drug conjugates leading to the formation of safer release of myriad of drugs for cancer chemoprevention. Results: The review concerns about tracing and detailing the drug delivery systems of cancer nanotechnology. Conclusion: Nanotechnology is bestowed with the design, depiction, fabrication, and application of nanostructures, and devices with their controlled delivery together with the imaging of the selected target site and drug release at the specific site of action.

scholarly journals Delaying Anticancer Drug Delivery by Self‐Assembly and Branching Effects of Minimalist Dendron–Drug Conjugates

2019 ◽  
Vol 25 (41) ◽  
pp. 9552-9552
Author(s):  
Florian Correard ◽  
Myriam Roy ◽  
Vincent Terrasson ◽  
Diane Braguer ◽  
Marie‐Anne Estève ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Self Assembly ◽  
Anticancer Drug Delivery ◽  
Drug Conjugates

scholarly journals Front Cover: Delaying Anticancer Drug Delivery by Self‐Assembly and Branching Effects of Minimalist Dendron–Drug Conjugates (Chem. Eur. J. 41/2019)

2019 ◽  
Vol 25 (41) ◽  
pp. 9548-9548
Author(s):  
Florian Correard ◽  
Myriam Roy ◽  
Vincent Terrasson ◽  
Diane Braguer ◽  
Marie‐Anne Estève ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Self Assembly ◽  
Front Cover ◽  
Anticancer Drug Delivery ◽  
Drug Conjugates

Delaying Anticancer Drug Delivery by Self‐Assembly and Branching Effects of Minimalist Dendron–Drug Conjugates

2018 ◽  
Vol 25 (41) ◽  
pp. 9586-9591 ◽  
Author(s):  
Florian Correard ◽  
Myriam Roy ◽  
Vincent Terrasson ◽  
Diane Braguer ◽  
Marie‐Anne Estève ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Self Assembly ◽  
Anticancer Drug Delivery ◽  
Drug Conjugates

Miktoarm star copolymers from D-(−)-salicin core aggregated into dandelion-like structures as anticancer drug delivery systems: synthesis, self-assembly and drug release

2016 ◽  
Vol 515 (1-2) ◽  
pp. 515-526 ◽  
Author(s):  
Anna Mielańczyk ◽  
Justyna Odrobińska ◽  
Sebastian Grządka ◽  
Łukasz Mielańczyk ◽  
Dorota Neugebauer
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Anticancer Drug ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Anticancer Drug Delivery ◽  
Star Copolymers ◽  
Miktoarm Star

Carbon Nanotubes, Quantum Dots and Dendrimers as Potential Nanodevices for Nanotechnology Drug Delivery Systems

2013 ◽  
Vol 6 (3) ◽  
pp. 2113-2124
Author(s):  
Prashant Malik ◽  
Neha Gulati ◽  
Raj Kaur Malik ◽  
Upendra Nagaich
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Atomic Scale ◽  
Sustained Drug Delivery ◽  
Pharmaceutical Nanotechnology ◽  
Conventional Device

Nanotechnology deal with the particle size in nanometers. Nanotechnology is ranging from extensions of conventional device physics to completely new approaches based upon molecular self assembly, from developing new materials with dimensions on the nanoscale to direct control of matter on the atomic scale. In nanotechnology mainly three types of nanodevices are described: carbon nanotubes, quantum dots and dendrimers. It is a recent technique used as small size particles to treat many diseases like cancer, gene therapy and used as diagnostics. Nanotechnology used to formulate targeted, controlled and sustained drug delivery systems. Pharmaceutical nanotechnology embraces applications of nanoscience to pharmacy as nanomaterials and as devices like drug delivery, diagnostic, imaging and biosensor materials. Pharmaceutical nanotechnology has provided more fine tuned diagnosis and focused treatment of disease at a molecular level.    

Doxorubicin delivery systems based on doped CaCO3 cores and polyanion drug conjugates

2021 ◽  
pp. 1-19
Author(s):  
Natalia Sudareva ◽  
Olga Suvorova ◽  
Natalia Saprykina ◽  
Helen Vlasova ◽  
Alexander Vilesov
Keyword(s):  
Delivery Systems ◽  
Drug Conjugates ◽  
Doxorubicin Delivery

scholarly journals Nitrite induces the extravasation of iron oxide nanoparticles in hypoxic tumor tissue

2014 ◽  
Vol 27 (4) ◽  
pp. 425-430 ◽  
Author(s):  
Nilesh Mistry ◽  
Ashley M. Stokes ◽  
James Van Gambrell ◽  
Christopher Chad Quarles
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Tumor Tissue ◽  
Oxide Nanoparticles ◽  
Hypoxic Tumor

Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems

2021 ◽  
pp. 113870
Author(s):  
Zhejie Chen ◽  
Mohamed A. Farag ◽  
Zhangfeng Zhong ◽  
Chen Zhang ◽  
Yu Yang ◽  
...  
Keyword(s):  
Delivery Systems ◽  
Nanodrug Delivery

scholarly journals Polymeric Drug Delivery System Based on Pluronics for Cancer Treatment

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3610
Author(s):  
Jialin Yu ◽  
Huayu Qiu ◽  
Shouchun Yin ◽  
Hebin Wang ◽  
Yang Li
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Tumor Therapy ◽  
Chemical Properties ◽  
Drug Carriers ◽  
Disease Diagnosis ◽  
Delivery Systems ◽  
Polymeric Drug Delivery ◽  
Physical And Chemical

Pluronic polymers (pluronics) are a unique class of synthetic triblock copolymers containing hydrophobic polypropylene oxide (PPO) and hydrophilic polyethylene oxide (PEO) arranged in the PEO-PPO-PEO manner. Due to their excellent biocompatibility and amphiphilic properties, pluronics are an ideal and promising biological material, which is widely used in drug delivery, disease diagnosis, and treatment, among other applications. Through self-assembly or in combination with other materials, pluronics can form nano carriers with different morphologies, representing a kind of multifunctional pharmaceutical excipients. In recent years, the utilization of pluronic-based multi-functional drug carriers in tumor treatment has become widespread, and various responsive drug carriers are designed according to the characteristics of the tumor microenvironment, resulting in major progress in tumor therapy. This review introduces the specific role of pluronic-based polymer drug delivery systems in tumor therapy, focusing on their physical and chemical properties as well as the design aspects of pluronic polymers. Finally, using newer literature reports, this review provides insights into the future potential and challenges posed by different pluronic-based polymer drug delivery systems in tumor therapy.

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