scholarly journals Apoptotic mechanisms of gastric cancer cells induced by isolated Erinacine S through epigenetic histone H3 methylation of FasL and TRAIL

2021 ◽  
Author(s):  
Hsing-Chun Kuo ◽  
Shui-Yi Tung ◽  
Ko-Chao Lee ◽  
Kam-Fai Lee ◽  
Ya-Ling Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Histone H3 ◽  
Ethanol Extract ◽  
Gastric Cancer Cells ◽  
Hericium Erinaceus ◽  
Histone H3 Methylation ◽  
Health Promoting ◽  
Great Health

Erinacine S, the new bioactive diterpenoid compound isolated from the ethanol extract of the mycelia of Hericium erinaceus, displays great health-promoting properties. However, the effects of erinacine S on inductive...

scholarly journals Suppressive effects of an ethanol extract of Gleditsia sinensis thorns on human SNU-5 gastric cancer cells

2013 ◽  
Vol 29 (4) ◽  
pp. 1609-1616 ◽  
Author(s):  
SE-JUNG LEE ◽  
DONG HEE RYU ◽  
LEE CHAN JANG ◽  
SEOK-CHEOL CHO ◽  
WUN-JAE KIM ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Ethanol Extract ◽  
Gastric Cancer Cells ◽  
Gleditsia Sinensis

scholarly journals The ethanol extract of Excoecaria cochinchinensis Lour. leaves inhibits cell migration and arrests cell cylce in gastric cancer cell MKN45

2021 ◽  
Vol 19 (1) ◽  
pp. 147-154
Author(s):  
Nguyen Phu Hung ◽  
Le Thi Thanh Huong
Keyword(s):  
Gastric Cancer ◽  
Cell Migration ◽  
Cancer Cells ◽  
Stomach Cancer ◽  
Leaf Extract ◽  
Ethanol Extract ◽  
Dependent Manner ◽  
Gastric Cancer Cells ◽  
Concentration Dependent Manner ◽  
The World

According to Globocan 2020, stomach cancer is the 5th most common cancer in the world. Vietnam belongs to the group of 20 countries with the highest rate of stomach cancer in the world with 17906 new cases and 14615 deaths in 2020. Natural medicinal products are gaining increasing popularity and use worldwide as complementary alternative therapies. Excoecaria cochinchinensis Lour. is an herb widely distributed in many Southeast Asian countries and China. Current understanding of the effects of E. cochinchinensis on cancer cells is limited. In this study, we collected ethanol extract from the leaves of E. cochinchinensis and assessed its impacts on MKN45 gastric cancer cells. Our study showed that the ethanol extract of the E. cochinchinensis leaves was able to strongly inhibit the proliferation of MKN45 gastric cancer cells, from 40% to 80% compared to the control, with an IC50 value of 0,07 mg/mL. On the other hand, the leaf extract also reduced the level of cell migration from 20% to 70% compared to the control in a concentration-dependent manner. Flow cytometry analysis also showed that the leaf extract arrested the cell cycle in G2/M phase (P < 0,05). Overall, the results showed that the leaf extract of Excoecaria cochinchinensis had the potential to inhibit gastric cancer cells.

Alpha-fetoprotein producing gastric cancer cells lack transcription factor AT-motif binding factor 1 (ATBF1)

2001 ◽  
Vol 120 (5) ◽  
pp. A31-A31
Author(s):  
H KATAOKA ◽  
T JOH ◽  
T OHSHIMA ◽  
Y ITOH ◽  
K SENOO ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factor ◽  
Cancer Cells ◽  
Alpha Fetoprotein ◽  
Gastric Cancer Cells ◽  
Binding Factor
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