Entrapment and release kinetics study of dyes from BSA microspheres forming a matrix and a reservoir system

2020 ◽  
Vol 8 (44) ◽  
pp. 10154-10161
Author(s):  
Kusha Sharma ◽  
Abed Saady ◽  
Avi Jacob ◽  
Ze’ev Porat ◽  
Aharon Gedanken
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Ultrasonic Irradiation ◽  
Bovine Serum ◽  
Release Kinetics ◽  
Kinetics Study ◽  
Reservoir System ◽  
System P

Two kinds of Bovine Serum Albumin (BSA)-loaded microspheres were prepared in water-organic bilayer systems using ultrasonic irradiation.

Sonocatalytic damage of bovine serum albumin (BSA) under ultrasonic irradiation by mixed TiO2/SiO2powder

2009 ◽  
Vol 84 (4) ◽  
pp. 538-546 ◽  
Author(s):  
Jun Wang ◽  
Na Ding ◽  
Zhaohong Zhang ◽  
Shixian Wang ◽  
Ying Guo ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Ultrasonic Irradiation ◽  
Bovine Serum ◽  
Sonocatalytic Damage

Identification of competitive inhibitors for bovine serum albumin from dynamic combinatorial libraries containing a bienzyme system

RSC Advances ◽  
2015 ◽  
Vol 5 (30) ◽  
pp. 23224-23228 ◽  
Author(s):  
Wei He ◽  
Zheng Fang ◽  
Zhao Yang ◽  
Dong Ji ◽  
Ketao Chen ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Size Exclusion Chromatography ◽  
Bovine Serum ◽  
Combinatorial Libraries ◽  
Size Exclusion ◽  
System P ◽  
Competitive Inhibitors ◽  
Exclusion Chromatography

Three dynamic combinatorial libraries (DCLs) have been generated by using esterification, combined with a protocol based on size-exclusion chromatography (SEC) and HRMS.

Ultrasensitive detection of nonlabelled bovine serum albumin using photothermal optical phase shift detection with UV excitation

The Analyst ◽  
2020 ◽  
Vol 145 (7) ◽  
pp. 2580-2585 ◽  
Author(s):  
Hisashi Shimizu ◽  
Shigenori Takeda ◽  
Kazuma Mawatari ◽  
Takehiko Kitamori
Keyword(s):  
Phase Shift ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Detection System ◽  
Ultrasensitive Detection ◽  
Optical Phase ◽  
System P ◽  
Shift Detection ◽  
Uv Excitation

Ultrasensitive detection of nonlabelled bovine serum albumin is performed in micro/nanofluidic chips using a photothermal optical phase shift (POPS) detection system.

Comment on “Physicochemical stimuli as tuning parameters to modulate the structure and stability of nanostructured lipid carriers and release kinetics of encapsulated antileprosy drugs” by R. Kanwar, M. Gradzielski, S. Prevost, G. Kaur, M. S. Appavou and S. K. Mehta, J. Mater. Chem. B, 2019, 7, 6539

2020 ◽  
Vol 8 (44) ◽  
pp. 10205-10208
Author(s):  
Jonghoon Kang ◽  
Albert M. Kang
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Release Kinetics ◽  
Nanostructured Lipid Carriers ◽  
Structure And Stability ◽  
Tuning Parameters ◽  
Kinetics Of

Entropy–enthalpy compensation describes a push–pull phenomenon in the binding of drug loaded nanostructured lipid carriers to bovine serum albumin.

The preparation of TiO2/hydroxylapatite (TiO2/HA) composite and sonocatalytic damage to bovine serum albumin (BSA) under ultrasonic irradiation

2011 ◽  
Vol 341 (1-2) ◽  
pp. 89-96 ◽  
Author(s):  
Xudong Jin ◽  
Yuwei Guo ◽  
Jun Wang ◽  
Zhiqiu Wang ◽  
Jingqun Gao ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Ultrasonic Irradiation ◽  
Bovine Serum ◽  
Sonocatalytic Damage

Spectroscopic study on the sonodynamic and sonocatalytic damage of anthraquinone derivants to bovine serum albumin under ultrasonic irradiation

2012 ◽  
Vol 132 (3) ◽  
pp. 818-825 ◽  
Author(s):  
Zhiqiu Wang ◽  
Jingqun Gao ◽  
Jun Wang ◽  
Ying Li ◽  
Kai Li ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Spectroscopic Study ◽  
Ultrasonic Irradiation ◽  
Bovine Serum ◽  
Sonocatalytic Damage

scholarly journals Enzyme Stability in Nanoparticle Preparations Part 1: Bovine Serum Albumin Improves Enzyme Function

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4593
Author(s):  
Jason Thomas Duskey ◽  
Federica da Ros ◽  
Ilaria Ottonelli ◽  
Barbara Zambelli ◽  
Maria Angela Vandelli ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Specific Activity ◽  
Enzyme Stability ◽  
Polymeric Nanoparticles ◽  
Release Kinetics ◽  
Titration Calorimetry ◽  
Therapeutic Effects

Enzymes have gained attention for their role in numerous disease states, calling for research for their efficient delivery. Loading enzymes into polymeric nanoparticles to improve biodistribution, stability, and targeting in vivo has led the field with promising results, but these enzymes still suffer from a degradation effect during the formulation process that leads to lower kinetics and specific activity leading to a loss of therapeutic potential. Stabilizers, such as bovine serum albumin (BSA), can be beneficial, but the knowledge and understanding of their interaction with enzymes are not fully elucidated. To this end, the interaction of BSA with a model enzyme B-Glu, part of the hydrolase class and linked to Gaucher disease, was analyzed. To quantify the natural interaction of beta-glucosidase (B-Glu,) and BSA in solution, isothermal titration calorimetry (ITC) analysis was performed. Afterwards, polymeric nanoparticles encapsulating these complexes were fully characterized, and the encapsulation efficiency, activity of the encapsulated enzyme, and release kinetics of the enzyme were compared. ITC results showed that a natural binding of 1:1 was seen between B-Glu and BSA. Complex concentrations did not affect nanoparticle characteristics which maintained a size between 250 and 350 nm, but increased loading capacity (from 6% to 30%), enzyme activity, and extended-release kinetics (from less than one day to six days) were observed for particles containing higher B-Glu:BSA ratios. These results highlight the importance of understanding enzyme:stabilizer interactions in various nanoparticle systems to improve not only enzyme activity but also biodistribution and release kinetics for improved therapeutic effects. These results will be critical to fully characterize and compare the effect of stabilizers, such as BSA with other, more relevant therapeutic enzymes for central nervous system (CNS) disease treatments.

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