Transdermal Delivery of Heparin using Low Frequency Sonophoresis in combination with Sponge Spicules for the Venous Thrombosis Treatment

2021 ◽  
Author(s):  
Haojie Zhai ◽  
Chi Zhang ◽  
Huilong Ou ◽  
Ming Chen
Keyword(s):  
Venous Thrombosis ◽  
Transdermal Delivery ◽  
Low Frequency ◽  
Sponge Spicules

This study reports the use of low-frequency sonophoresis (LFS) in combination with sponge Haliclona sp. spicules (SHS), referred to as cSoSp (combined Sonophoresis and Spicules), can enhance the transdermal drug...

Transdermal Delivery Of Macromolecules Using Nanolipid Carriers

2021 ◽  
Vol 27 ◽  
Author(s):  
Sana Kalave ◽  
Bappaditya Chatterjee ◽  
Parth Shah ◽  
Ambikanandan Misra
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Low Frequency ◽  
Nanostructured Lipid Carriers ◽  
Skin Damage ◽  
Low Frequency Ultrasound ◽  
Transdermal Delivery System ◽  
Nanolipid Carriers ◽  
Transport Of Macromolecules ◽  
Frequency Ultrasound

: Skin being the largest external organ, offers an enticing procedure for transdermal drug delivery, so the drug needs to rise above the outermost layer of the skin, i.e., stratum corneum. Small molecular drug entities obeying the Lipinski rule, i.e., drugs having a molecular weight less than 500Da, high lipophilicity, and optimum polarity, are favored enough to be used on the skin as therapeutics. Skin's barrier action properties prevent the transport of macromolecules at pre-determined therapeutic rates. Notable advancement in macromolecules' transdermal delivery occurred in recent years. Scientists have opted for liposomes, the use of electroporation or, low-frequency ultrasound techniques. Some of these have shown better delivery of macromolecules at clinically beneficial rates. These physical technologies involve complex mechanisms, which may irreversibly incur skin damage. Majorly, two types of lipid-based formulations, including Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) are widely investigated as a transdermal delivery system. In this review, the concepts, mechanisms, and applications of Nanostructured Lipid Carriers that are considered feasible for transporting macromolecules via transdermal delivery system are thoroughly reviewed and presented along with their clinical perspective.

scholarly journals Transdermal Delivery of Enfuvirtide in a Porcine Model Using a Low-Frequency, Low-Power Ultrasound Transducer Patch

2019 ◽  
Vol 45 (2) ◽  
pp. 513-525 ◽  
Author(s):  
Kevin A. Snook ◽  
Robert Van Ess ◽  
Jacob R. Werner ◽  
Ryan S. Clement ◽  
Olga M. Ocon-Grove ◽  
...  
Keyword(s):  
Low Power ◽  
Transdermal Delivery ◽  
Porcine Model ◽  
Low Frequency ◽  
Ultrasound Transducer ◽  
Power Ultrasound

Low frequency ultrasound and PAMAM dendrimer facilitated transdermal delivery of ketoprofen

2017 ◽  
Vol 41 ◽  
pp. 334-343 ◽  
Author(s):  
Jyothsna Manikkath ◽  
Aparna Manikkath ◽  
Gopal Venkatesh Shavi ◽  
Krishnamurthy Bhat ◽  
Srinivas Mutalik
Keyword(s):  
Transdermal Delivery ◽  
Low Frequency ◽  
Pamam Dendrimer ◽  
Low Frequency Ultrasound ◽  
Frequency Ultrasound

scholarly journals A nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosis

Blood ◽  
2006 ◽  
Vol 108 (1) ◽  
pp. 177-183 ◽  
Author(s):  
Javier Corral ◽  
Rocio González-Conejero ◽  
Jose Manuel Soria ◽  
Jose Ramón González-Porras ◽  
Elena Pérez-Ceballos ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Venous Thrombosis ◽  
Stop Codon ◽  
Anticoagulant Activity ◽  
Low Frequency ◽  
Protein Z ◽  
Antithrombin Deficiency ◽  
Thrombotic Risk ◽  
Genetic Modifications ◽  
History Of

The protein Z-dependent protease inhibitor (ZPI) is a hemostatic serpin with anticoagulant activity. As for antithrombin, deficiency of ZPI could have relevant thrombotic consequences. We have studied 6 genetic modifications affecting the ZPI gene, identifying 5 haplotypes. Haplotype H5 is featured by a stop codon at position 67. The relevance of these genetic modifications and haplotypes in venous thrombosis was evaluated in a case-control study including 1018 patients and 1018 age- and sex-matched controls. Surprisingly, the H5 haplotype was found in 0.9% of controls, supporting that the Arg67Stop change is a low frequency nonsense polymorphism. The prevalence of this haplotype increased significantly in patients (3.0%), one of whom was in a homozygous state. Multivariate analysis confirms that carriers have a 3.3-fold risk of developing venous thrombosis (P = .002; 95% CI: 1.5-7.1). Moreover, we observed a significant association of this polymorphism with familial history of thrombosis (P < .001). Our study supports that the ZPI Arg67Stop nonsense polymorphism might be an independent genetic risk factor for venous thrombosis. This polymorphism has slightly lower prevalence but similar thrombotic risk than the FV Leiden or prothrombin 20210A. Although further studies are required, all available data support that the ZPI is a candidate to play a significant role in thrombosis and should be evaluated in thrombophilic studies. (Blood. 2006;108:177-183)

scholarly journals Transdermal delivery of fluorescein isothiocyanate-dextrans using the combination of microneedles and low-frequency sonophoresis

2015 ◽  
Vol 10 (5) ◽  
pp. 415-424 ◽  
Author(s):  
Boonnada Pamornpathomkul ◽  
Sureewan Duangjit ◽  
Suvida Laohapatarapant ◽  
Theerasak Rojanarata ◽  
Praneet Opanasopit ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Low Frequency ◽  
Fluorescein Isothiocyanate
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