Sign dependence of MCPL spectra on type and position of substituent groups of pyrene and phenanthrene derivatives

2021 ◽  
Vol 23 (14) ◽  
pp. 8236-8240
Author(s):  
Nobuyuki Hara ◽  
Maho Kitahara ◽  
Takaharu Sugimura ◽  
Hayato Toda ◽  
Motohiro Shizuma ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Dilute Solution ◽  
Carboxylic Acid Groups

Achiral pyrene and phenanthrene derivatives with electron-donating hydroxyl/methoxy and electron-withdrawing carboxylic acid groups exhibited magnetic circularly polarised luminescence at 360–410 nm in dilute solution under N-up and S-up Faraday geometries at 1.6 T.

scholarly journals Grafting TRAIL through Either Amino or Carboxylic Groups onto Maghemite Nanoparticles: Influence on Pro-Apoptotic Efficiency

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 502
Author(s):  
Hanene Belkahla ◽  
Andrei Alexandru Constantinescu ◽  
Tijani Gharbi ◽  
Florent Barbault ◽  
Alexandre Chevillot-Biraud ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Cancer Therapy ◽  
Computational Study ◽  
Carcinoma Cells ◽  
Maghemite Nanoparticles ◽  
Carboxylic Acid Groups ◽  
Lung Carcinoma Cells ◽  
Biological Studies ◽  
Apoptotic Effect ◽  
Carboxylic Groups

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF cytokine superfamily. TRAIL is able to induce apoptosis through engagement of its death receptors DR4 and DR5 in a wide variety of tumor cells while sparing vital normal cells. This makes it a promising agent for cancer therapy. Here, we present two different ways of covalently grafting TRAIL onto maghemite nanoparticles (NPs): (a) by using carboxylic acid groups of the protein to graft it onto maghemite NPs previously functionalized with amino groups, and (b) by using the amino functions of the protein to graft it onto NPs functionalized with carboxylic acid groups. The two resulting nanovectors, NH-TRAIL@NPs-CO and CO-TRAIL@NPs-NH, were thoroughly characterized. Biological studies performed on human breast and lung carcinoma cells (MDA-MB-231 and H1703 cell lines) established these nanovectors are potential agents for cancer therapy. The pro-apoptotic effect is somewhat greater for CO-TRAIL@NPs-NH than NH-TRAIL@NPs-CO, as evidenced by viability studies and apoptosis analysis. A computational study indicated that regardless of whether TRAIL is attached to NPs through an acid or an amino group, DR4 recognition is not affected in either case.

Dual-temperature and pH responsive (ethylene glycol)-based nanogels via structural design

2014 ◽  
Vol 5 (8) ◽  
pp. 3061-3070 ◽  
Author(s):  
Yohei Kotsuchibashi ◽  
Ravin Narain
Keyword(s):  
Carboxylic Acid ◽  
Ethylene Glycol ◽  
Salt Concentration ◽  
Structural Design ◽  
Solution Temperature ◽  
Ph Responsive ◽  
Solution Ph ◽  
Critical Solution Temperature ◽  
Carboxylic Acid Groups ◽  
The Core

Dual-temperature and pH responsive (ethylene glycol)-based nanogels were synthesized. Both the core and the shell of the nanogels showed a lower critical solution temperature (LCST) and the LCST of the shell was strongly affected by the solution pH and salt concentration due to the presence of carboxylic acid groups at the nanogel surface.

Metal ion retention properties of water-insoluble polymers containing carboxylic acid groups

2005 ◽  
Vol 99 (3) ◽  
pp. 697-705 ◽  
Author(s):  
Bernabé L. Rivas ◽  
Benita Quilodrán ◽  
Eduardo Quiroz
Keyword(s):  
Carboxylic Acid ◽  
Metal Ion ◽  
Carboxylic Acid Groups ◽  
Insoluble Polymers

Oxidation of poly[bis(4-methylphenoxy)phosphazene] surfaces and chemistry of the surface carboxylic acid groups

1992 ◽  
Vol 4 (4) ◽  
pp. 769-775 ◽  
Author(s):  
Harry R. Allcock ◽  
Richard J. Fitzpatrick ◽  
Lawrence Salvati
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acid Groups

Direct synthesis of ordered and highly functionalized organosilicas containing carboxylic acid groups

2007 ◽  
Vol 17 (7) ◽  
pp. 616 ◽  
Author(s):  
Rola Mouawia ◽  
Ahmad Mehdi ◽  
Catherine Rey? ◽  
Robert Corriu
Keyword(s):  
Carboxylic Acid ◽  
Direct Synthesis ◽  
Carboxylic Acid Groups

scholarly journals Crystal structure of betulinic acid methanol monosolvate

2014 ◽  
Vol 70 (12) ◽  
pp. o1242-o1243 ◽  
Author(s):  
Wei Tang ◽  
Neng-Hua Chen ◽  
Guo-Qiang Li ◽  
Guo-Cai Wang ◽  
Yao-Lan Li
Keyword(s):  
Carboxylic Acid ◽  
Solvent Molecule ◽  
Acid Group ◽  
Carboxylic Acid Group ◽  
Syzygium Jambos ◽  
Carboxylic Acid Groups ◽  
Pentacyclic Triterpenoid ◽  
Naturally Occurring ◽  
Dimensional Network ◽  
Chinese Medicinal Plant

The title compound [systematic name: 3β-hydroxylup-20(29)-en-28-oic acid methanol monosolvate], C30H48O3·CH3OH, is a solvent pseudopolymorph of a naturally occurring plant-derived lupane-type pentacyclic triterpenoid, which was isolated from the traditional Chinese medicinal plantSyzygium jambos(L.) Alston. The dihedral angle between the planes of the carboxylic acid group and the olefinic group is 12.17 (18)°. TheA/B,B/C,C/DandD/Ering junctions are alltrans-fused. In the crystal, O—H...O hydrogen bonds involving the hydroxy and carboxylic acid groups and the methanol solvent molecule give rise to a two-dimensional network structure lying parallel to (001).

scholarly journals A new solvate of epalerstat, a drug for diabetic neuropathy

2017 ◽  
Vol 73 (8) ◽  
pp. 1264-1267 ◽  
Author(s):  
Okky Dwichandra Putra ◽  
Daiki Umeda ◽  
Kaori Fukuzawa ◽  
Mihoko Gunji ◽  
Etsuo Yonemochi
Keyword(s):  
Hydrogen Bond ◽  
Acetic Acid ◽  
Carboxylic Acid ◽  
Hydrogen Bonds ◽  
Diabetic Neuropathy ◽  
Dihedral Angle ◽  
Phenyl Ring ◽  
Acid Moiety ◽  
Acta Cryst ◽  
Carboxylic Acid Groups

Epalerstat {systematic name: (5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidine-3-acetic acid} crystallized as an acetone monosolvate, C15H13NO3S2·C3H6O. In the epalerstat molecule, the methylpropylenediene moiety is inclined to the phenyl ring and the five-membered rhodamine ring by 21.4 (4) and 4.7 (4)°, respectively. In addition, the acetic acid moiety is found to be almost normal to the rhodamine ring, making a dihedral angle of 85.1 (2)°. In the crystal, a pair of O—H...O hydrogen bonds between the carboxylic acid groups of epalerstat molecules form inversion dimers with an R 2 2(8) loop. The dimers are linked by pairs of C—H...O hydrogen bonds, enclosing R 2 2(20) loops, forming chains propagating along the [101] direction. In addition, the acetone molecules are linked to the chain by a C—H...O hydrogen bond. Epalerstat acetone monosolvate was found to be isotypic with epalerstat tertrahydrofuran solvate [Umeda et al. (2017). Acta Cryst. E73, 941–944].

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