Chitosan oligosaccharide attenuates endoplasmic reticulum stress- associated intestinal apoptosis via Akt/mTOR pathway

2021 ◽  
Author(s):  
Tingting Fang ◽  
Ying Yao ◽  
Gang Tian ◽  
Daiwen Chen ◽  
Aimin Wu ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Disease Activity ◽  
Mtor Pathway ◽  
Chitosan Oligosaccharide ◽  
Therapeutic Approaches ◽  
Factors Associated ◽  
Control Disease

Endoplasmic reticulum stress (ERS) and apoptosis are widely considered as essential factors associated with intestinal disorders, whereas nutritional therapeutic approaches target for ERS may control disease activity. Thus, we focus...

scholarly journals GADD34 Keeps the mTOR Pathway Inactivated in Endoplasmic Reticulum Stress Related Autophagy

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0168359 ◽  
Author(s):  
Marianna Holczer ◽  
Gábor Bánhegyi ◽  
Orsolya Kapuy
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Mtor Pathway

Chitosan oligosaccharide ameliorated obesity by reducing endoplasmic reticulum stress in diet-induced obese rats

2020 ◽  
Vol 11 (7) ◽  
pp. 6285-6296 ◽  
Author(s):  
Xiaoyi Deng ◽  
Zhijun Ye ◽  
Hua Cao ◽  
Yan Bai ◽  
Qishi Che ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Lipid Metabolism ◽  
Endoplasmic Reticulum Stress ◽  
High Fat Diet ◽  
Chitosan Oligosaccharide ◽  
High Fat ◽  
Chitosan Oligosaccharides ◽  
Obese Rats

Chitosan oligosaccharides can alleviate liver endoplasmic reticulum stress to improve lipid metabolism and reduce obesity caused by high-fat diet.

scholarly journals Induction of the Endoplasmic-Reticulum-Stress Response: MicroRNA-34a Targeting of the IRE1α-Branch

Cells ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 1442
Author(s):  
Lena Krammes ◽  
Martin Hart ◽  
Stefanie Rheinheimer ◽  
Caroline Diener ◽  
Jennifer Menegatti ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Stress Response ◽  
Endoplasmic Reticulum Stress ◽  
Neurodegenerative Disorders ◽  
Endoplasmic Reticulum Stress Response ◽  
Caspase Activity ◽  
Therapeutic Approaches ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

Neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by the accumulation of misfolded proteins in the endoplasmic reticulum (ER) and the unfolded protein response (UPR). Modulating the UPR is one of the major challenges to counteract the development of neurodegenerative disorders and other diseases with affected UPR. Here, we show that miR-34a-5p directly targets the IRE1α branch of the UPR, including the genes BIP, IRE1α, and XBP1. Upon induction of ER stress in neuronal cells, miR-34a-5p overexpression impacts the resulting UPR via a significant reduction in IRE1α and XBP1s that in turn leads to decreased viability, increased cytotoxicity and caspase activity. The possibility to modify the UPR signaling pathway by a single miRNA that targets central genes of the IRE1α branch offers new perspectives for future therapeutic approaches against neurodegeneration.

scholarly journals α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway

2015 ◽  
Vol 6 (8) ◽  
pp. e1860-e1860 ◽  
Author(s):  
M Hasanain ◽  
A Bhattacharjee ◽  
P Pandey ◽  
R Ashraf ◽  
N Singh ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Mtor Pathway
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