Malvidin and its derivatives exhibit antioxidant properties by inhibiting MAPK signaling pathways to reduce endoplasmic reticulum stress in ARPE-19 cells

2021 ◽  
Author(s):  
Xinyao Liu ◽  
Fei Zheng ◽  
Sheng Li ◽  
Zhitong Wang ◽  
Xinyuan Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Signaling Pathways ◽  
Molecular Mechanism ◽  
Antioxidant Properties ◽  
Mapk Signaling ◽  
Mapk Signaling Pathways

Diagram of the molecular mechanism of MV, Mv3C, and Mv3ACEC protecting ARPE-19 cells against oxidative stress.

scholarly journals Shen-Kang protects 5/6 nephrectomized rats against renal injury by reducing oxidative stress through the MAPK signaling pathways

2015 ◽  
Vol 36 (4) ◽  
pp. 975-984 ◽  
Author(s):  
MEIYOU LIU ◽  
JISOO PARK ◽  
XIAOXIAO WU ◽  
YUWEN LI ◽  
QUANGDON TRAN ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathways ◽  
Renal Injury ◽  
Mapk Signaling ◽  
Mapk Signaling Pathways

scholarly journals Myricetin Protects Cells against Oxidative Stress-Induced Apoptosis via Regulation of PI3K/Akt and MAPK Signaling Pathways

2010 ◽  
Vol 11 (11) ◽  
pp. 4348-4360 ◽  
Author(s):  
Kyoung Ah Kang ◽  
Zhi Hong Wang ◽  
Rui Zhang ◽  
Mei Jing Piao ◽  
Ki Cheon Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathways ◽  
Mapk Signaling ◽  
Induced Apoptosis ◽  
Mapk Signaling Pathways

scholarly journals Weaning Induced Hepatic Oxidative Stress, Apoptosis, and Aminotransferases through MAPK Signaling Pathways in Piglets

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Zhen Luo ◽  
Wei Zhu ◽  
Qi Guo ◽  
Wenli Luo ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathways ◽  
Redox Status ◽  
Mapk Signaling ◽  
Mitogen Activated Protein Kinase ◽  
Control Group ◽  
Hepatic Oxidative Stress ◽  
Mitogen Activated Protein ◽  
D 20 ◽  
Mapk Signaling Pathways

This study investigated the effects of weaning on the hepatic redox status, apoptosis, function, and the mitogen-activated protein kinase (MAPK) signaling pathways during the first week after weaning in piglets. A total of 12 litters of piglets were weaned at d 21 and divided into the weaning group (WG) and the control group (CG). Six piglets from each group were slaughtered at d 0 (d 20, referred to weaning), d 1, d 4, and d 7 after weaning. Results showed that weaning significantly increased the concentrations of hepatic free radicals H2O2and NO, malondialdehyde (MDA), and 8-hydroxy-2′-deoxyguanosine (8-OHdG), while significantly decreasing the inhibitory hydroxyl ability (IHA) and glutathione peroxidase (GSH-Px), and altered the level of superoxide dismutase (SOD). The apoptosis results showed that weaning increased the concentrations of caspase-3, caspase-8, caspase-9 and the ratio of Bax/Bcl-2. In addition, aspartate aminotransferase transaminase (AST) and alanine aminotransferase (ALT) in liver homogenates increased after weaning. The phosphorylated JNK and ERK1/2 increased, while the activated p38 initially decreased and then increased. Our results suggested that weaning increased the hepatic oxidative stress and aminotransferases and initiated apoptosis, which may be related to the activated MAPK pathways in postweaning piglets.

scholarly journals Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways

2012 ◽  
Vol 31 (3) ◽  
pp. 545-557 ◽  
Author(s):  
Patrick T. Grogan ◽  
Kristina D. Sleder ◽  
Abbas K. Samadi ◽  
Huaping Zhang ◽  
Barbara N. Timmermann ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heat Shock ◽  
Signaling Pathways ◽  
Heat Shock Response ◽  
Mapk Signaling ◽  
Withaferin A ◽  
Shock Response ◽  
Mapk Signaling Pathways

Long-term blue light exposure induces RGC-5 cell death in vitro: involvement of mitochondria-dependent apoptosis, oxidative stress, and MAPK signaling pathways

APOPTOSIS ◽  
2014 ◽  
Vol 19 (6) ◽  
pp. 922-932 ◽  
Author(s):  
Chen Huang ◽  
Pei Zhang ◽  
Wei Wang ◽  
Yongsheng Xu ◽  
Minshu Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Signaling Pathways ◽  
Blue Light ◽  
Light Exposure ◽  
Mapk Signaling ◽  
Mapk Signaling Pathways
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