A mimotope attached to an ITIM–SHP-1 interaction inhibitory peptide boosts immune response and efficacy

2021 ◽  
Author(s):  
Koushik Roy ◽  
Syamal Roy ◽  
Siddhartha Roy
Keyword(s):  
Immune Response ◽  
Antibody Production ◽  
Fc Receptor ◽  
Inhibitory Peptide ◽  
Peptide Antigen ◽  
Conformationally Constrained

Conformationally-constrained antigen is more immunogenic and attenuation of inhibitory Fc receptor by ITIM mimicking peptide enhance antibody production to a defined peptide antigen.

scholarly journals DNA epitope vaccine containing complement component C3d enhances anti-amyloid-β antibody production and polarizes the immune response towards a Th2 phenotype

2008 ◽  
Vol 205 (1-2) ◽  
pp. 57-63 ◽  
Author(s):  
Nina Movsesyan ◽  
Mikayel Mkrtichyan ◽  
Irina Petrushina ◽  
Ted M. Ross ◽  
David H. Cribbs ◽  
...  
Keyword(s):  
Immune Response ◽  
Antibody Production ◽  
Amyloid Β ◽  
Complement Component ◽  
Epitope Vaccine

scholarly journals Immunomodulatory action of jacalin from Artocarpus integrifolia and mannoprotein from Saccharomyces uvarum on the humoral immunity of laying hens

2020 ◽  
Vol 50 (4) ◽  
Author(s):  
Marco Aurélio Chiara Silva ◽  
Miriele Caroline da Silva ◽  
João Waine Pinheiro ◽  
Raul Jorge Hernan Castro-Goméz ◽  
Alice Eiko Murakami ◽  
...  
Keyword(s):  
Immune Response ◽  
Protein Interactions ◽  
Antibody Production ◽  
Laying Hens ◽  
Lectin Binding ◽  
Primary Immune Response ◽  
Immunomodulatory Effects ◽  
Saccharomyces Uvarum ◽  
Immunomodulatory Properties ◽  
Artocarpus Integrifolia

ABSTRACT: Advances in the fields of glycobiology and immunology have provided many insights into the role of carbohydrate-protein interactions in the immune system. Jacalin of Artocarpus integrifolia (JCA) and structural mannoprotein of Saccharomyces uvarum (MPS) are molecules with immunomodulatory properties. JCA is an IgA human lectin binding molecule that causes the mitogenic stimulation of immune cells, production of cytokines, chemotaxis, and activation of leukocytes. Studies on the immunomodulatory properties of JCA and MPS in mammals and fish suggest that they have an action on antibody production. The aim of this study was to investigate the possible action of JCA and MPS on the production of specific antibodies in laying hens. For this, laying hens were inoculated with an intra abdominal injection of sheep red blood cells (SRBC) with either JCA (0.075 µg, 0.75 µg, and 7.5 µg) or MPS (20 µg and 100 µg). Levels of anti-SRBC antibodies of the IgY, IgM, and IgA classes were evaluated by ELISA. Results showed that JCA and MPS have immunomodulatory effects on levels of anti-SRBC IgM, IgA, and IgY. An immunostimulatory effect of JCA was observed in primary immune response on anti-SRBC IgY, while an inhibitory effect of JCA and MPS was observed in secondary immune response on the production of IgM and IgA anti-SRBC. These results suggested that MPS and JCA have immunomodulatory effects on antibody production and could be used in future studies on humoral immune response in poultry.

scholarly journals Promiscuous T cell epitopes boosts specific IgM immune response against a P0 peptide antigen from sea lice in different teleost species

2019 ◽  
Vol 92 ◽  
pp. 322-330 ◽  
Author(s):  
Yeny Leal ◽  
Janet Velazquez ◽  
Liz Hernandez ◽  
Jaya Kumari Swain ◽  
Alianet Rodríguez Rodríguez ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Sea Lice ◽  
T Cell Epitopes ◽  
Peptide Antigen ◽  
Teleost Species

scholarly journals GENETIC CONTROL OF THE IMMUNE RESPONSE

1972 ◽  
Vol 136 (5) ◽  
pp. 1195-1206 ◽  
Author(s):  
John C. Ordal ◽  
F. Carl Grumet
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Genetic Control ◽  
Antibody Production ◽  
Lymphoid Cells ◽  
Antigen Challenge ◽  
Graft Versus Host ◽  
K Cells

The transfer of parental (H-2k/k) nonresponder lymphoid cells into heterozygous (H-2k/q) nonresponder recipients at the time of primary challenge with aqueous poly-L(Tyr,Glu)-poly-D,L-Ala-poly-L-Lys [(T,G)-A--L] elicited the production of both IgM and IgG anti-(T,G)-A--L antibody. Normally, the production of IgG anti-(T,G)-A--L antibody is restricted to strains possessing the responder Ir-1 allele. The timing and intensity of the graft-versus-host (GVH) reaction required for this effect were found to be critical. Injection of H-2k/k cells into H-2k/q recipients 1 wk before antigen challenge did not elicit IgG anti-(T,G)-A--L antibody production, and markedly suppressed IgM anti-(T,G)-A--L antibody production. The transfer of alloimmune (H-2q-primed) H-2k/k cells at the time of antigen challenge was also associated with no IgG and little IgM anti-(T,G)-A--L antibody production. These data are consistent with the model that nonresponder thymus-derived lymphocytes (T cells) activated in a GVH reaction can substitute for (T,G)-A--L-reactive T cells to induce a shift from IgM to IgG anti-(T,G)-A--L antibody production.

Induction of immune response against a short synthetic peptide antigen coupled to small neutral liposomes containing monophosphoryl lipid a

1993 ◽  
Vol 30 (6) ◽  
pp. 539-547 ◽  
Author(s):  
Martin Friede ◽  
Sylviane Muller ◽  
Jean-Paul Briand ◽  
Marc H.V. Van Regenmortel ◽  
Francis Schuber
Keyword(s):  
Immune Response ◽  
Synthetic Peptide ◽  
Lipid A ◽  
Peptide Antigen ◽  
Monophosphoryl Lipid A ◽  
Monophosphoryl Lipid

scholarly journals INDUCTION AND REVERSAL OF IMMUNE PARALYSIS IN VITRO

1970 ◽  
Vol 132 (5) ◽  
pp. 845-857 ◽  
Author(s):  
V. S. Byers ◽  
E. E. Sercarz
Keyword(s):  
Immune Response ◽  
Cell Proliferation ◽  
Lymph Node ◽  
Cell Population ◽  
Antibody Production ◽  
Cellular Environment ◽  
Immune Paralysis ◽  
Antigen Removal ◽  
The Postponement

Induction of the immune response can only be completed after antigen is removed from the cellular environment. Primed rabbit lymph node fragments were cultured in vitro with 5 mg/ml BSA. If antigen was removed from the fragments 2 hr later, they produced a normal anti-BSA response, which was first evident 5 days later. If antigen removal was delayed for 3 days, the onset of the response was postponed for 2 to 3 days. Pulses with BUDR marked the periods of cell proliferation in both sets of cultures, and established that the postponement of antibody production was preceded by a postponement in the wave of proliferation among precursors of antibody forming cells. The similarity in avidity of antibody-containing fluids from normal and postponed cultures support the idea that the same cell population produced the response in each case. It was concluded that a reversible state of paralysis could be instituted in antigen-responsive cells, and this state did not depend upon cell-killing. The widespread incidence of temporary paralysis as an early aspect of the immune response was discussed.

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