scholarly journals Ultrasmall prussian blue nanoparticles attenuate UVA-induced cellular senescence in human dermal fibroblasts via inhibiting ERK/AP-1 pathway

Nanoscale ◽  
2021 ◽  
Author(s):  
Yueyue Li ◽  
Ni Zeng ◽  
Zhiguo Qin ◽  
Yihe Chen ◽  
Qian Lu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Prussian Blue ◽  
Cellular Senescence ◽  
Dermal Fibroblasts ◽  
Oxygen Species ◽  
Human Dermal Fibroblasts ◽  
Ultraviolet A ◽  
Uva Irradiation ◽  
Prussian Blue Nanoparticles ◽  
Skin Photoaging

Ultraviolet A (UVA) irradiation can induce cellular senescence and cause skin photoaging, which is mainly driven by excessive production of reactive oxygen species (ROS). Emerging studies have focused on new...

scholarly journals Antioxidative and antiphotoaging activities of neferine upon UV-A irradiation in human dermal fibroblasts

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Abidullah khan ◽  
Hongliang Bai ◽  
Maoguo Shu ◽  
Mingxia Chen ◽  
Amin Khan ◽  
...  
Keyword(s):  
Deleterious Effect ◽  
Dermal Fibroblasts ◽  
The Other ◽  
Oxygen Species ◽  
Human Dermal Fibroblasts ◽  
Ultraviolet A ◽  
Enzymatic Antioxidant ◽  
Matrix Metalloproteinase 1 ◽  
Prevention And Treatment ◽  
Skin Photoaging

Our daily exposure to ultraviolet radiation (UVR) results in the production of reactive oxygen species (ROS), lipids, proteins and DNA damage and alteration in fibroblast structure, thus contributing to skin photoaging. For this reason, the use of natural bioactive compounds with antioxidant activity could be a strategic tool to overcome ultraviolet A (UV-A) induced deleterious effect. Neferine is an alkaloid extract from the seed embryos of lotus (Nelumbo nucifera Gaertn). In the present study, we report the protective effect of neferine against UV-A induced oxidative stress and photoaging in human dermal fibroblasts (HDFs). HDFs subjected to UV-A irradiation showed increased production of ROS and malondialdehyde (MDA). Furthermore, it depleted the cellular enzymatic antioxidant superoxide dismutase (SOD) and non-enzymatic antioxidant glutathione peroxidase (GPx). On the other hand, HDFs treated with neferine followed by UV-A irradiation reversed the process, reduced the ROS and lipid peroxidation and restored the antioxidants pool. Moreover, neferine treatment significantly inhibited UV-A induced matrix metalloproteinase-1 (MMP-1) expression in HDFs. Remarkable morphological and ultrastructural alterations observed in HDFs upon UV-A irradiation, were also reduced with neferine treatment. Taken together, our results suggest that neferine has strong antioxidative and photoprotective properties and thus may be a potential agent for the prevention and treatment of UV-A mediated skin photoaging.

scholarly journals Galvanic microparticles increase migration of human dermal fibroblasts in a wound-healing model via reactive oxygen species pathway

2014 ◽  
Vol 320 (1) ◽  
pp. 79-91 ◽  
Author(s):  
Nina Tandon ◽  
Elisa Cimetta ◽  
Aranzazu Villasante ◽  
Nicolette Kupferstein ◽  
Michael D. Southall ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Reactive Oxygen ◽  
Dermal Fibroblasts ◽  
Oxygen Species ◽  
Human Dermal Fibroblasts ◽  
Wound Healing Model ◽  
Healing Model

Effect of Reactive Oxygen Species on the Elastin mRNA Expression in Cultured Human Dermal Fibroblasts

1997 ◽  
Vol 23 (1) ◽  
pp. 162-165 ◽  
Author(s):  
Yoshiharu Kawaguchi ◽  
Hiroshi Tanaka ◽  
Tomio Okada ◽  
Hiroaki Konishi ◽  
Masahide Takahashi ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Mrna Expression ◽  
Reactive Oxygen ◽  
Dermal Fibroblasts ◽  
Oxygen Species ◽  
Human Dermal Fibroblasts

Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers

2016 ◽  
Vol 138 (18) ◽  
pp. 5860-5865 ◽  
Author(s):  
Wei Zhang ◽  
Sunling Hu ◽  
Jun-Jie Yin ◽  
Weiwei He ◽  
Wei Lu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Prussian Blue ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Prussian Blue Nanoparticles
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