great achievement
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2021 ◽  
Author(s):  
Yusriadi Yusriadi

The welfare state was a great achievement of civilisation in the 20th century. In this century, the State equips civil rights and freedoms with social rights. That is why democracy and the welfare state must go hand in hand. The welfare state has freedom with millions of people from their various social origins to fight market difficulties and open opportunities in life. Among other things, economic power can identify global competition, free markets, and various kinds of public policies that are oppressive. Market liberalisation demands social and economic resilience of the people so that the tide of the free market does not displace it. The modern economy is not just a slogan, but needs to be actualised to empower the economic capabilities of the lower classes of society.


2021 ◽  
Vol 55 (9-10) ◽  
pp. 971-979
Author(s):  
SHAKIBA BAGHERI ◽  
◽  
MEHDI RAHMANINIA ◽  
RABI BEHROOZ ◽  
◽  
...  

Using lignocellulosic materials for producing more value-added bioproducts is an attractive mission. Fiber fines, which represent an important part of the wastes generated by paper recycling mills, have been considered in the current research. Dissolving these lignocellulosic residues in environmentally friendly and inexpensive solvents can be a great achievement. For this purpose, the performance of urea/sodium hydroxide in dissolving printing and writing pulp (RPW) fines was investigated. Although using sodium hydroxide alone had a positive effect on the dissolution of recycled printing and writing pulp (RPWP) fines, the addition of urea increased the dissolution of fines from 23% to 56%. Different levels of urea consumption had no significant effect on the dissolving process. The performance of the urea/sodium hydroxide system in dissolving fines suspensions with different concentration (1, 3 and 5%) showed that reducing the concentration leads to an increase in fines dissolution (56, 36 and 7%, respectively). The results of FTIR confirmed the presence of cellulose without any hemicelluloses and lignin in the dissolving part. The results of X-ray diffraction analysis of soluble cellulose showed that the type-I cellulose structure probably changed to type-II cellulose. No reduction in the DP of dissolved cellulose and the integrated structure of the final cellulosic film confirmed by the FE-SEM images affirmed the successful dissolution of the RPWP fines in this system.


2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Yu-Bo Ma ◽  
Ming Gao ◽  
Tong-Dian Zhang ◽  
Tie Chong ◽  
He-Cheng Li ◽  
...  

In the past two decades, testicular tissue grafting and xenografting have been well established, with the production of fertilization-competent sperm in some studies. However, few studies have been carried out to observe the development of grafted prepubertal testicular tissue of rats and compare the biological differences between in situ testis and grafted testis. In this study, we established the prepubertal testicular tissue xenografting model using a 22-day-old rat and evaluated certain parameters, including testicular histology, testosterone production, and ultrastructure of the grafted testes. We also assessed gene expression of cell proliferation markers, testicular cell markers, and antioxidative defense system. Our results showed that 47 days after transplantation, intratesticular testosterone concentration was not significantly altered; however, cell proliferation, spermatogenesis, and Sertoli cell markers in the transplanted testes were significantly disrupted compared with the control group, accompanied by aggravated apoptosis and oxidative damage. Moreover, the transplanted testes showed smaller tubular diameter and disrupted spermatogenic epithelium with apparent vacuoles, distorted and degenerated germ cells with obscure nuclear margin, and no spermatids in the center of the tubules. Although testis xenografting has been extensively tested and attained great achievement in other species, the prepubertal rat testicular tissue xenografting to immunodeficient mice exhibited obvious spermatogenesis arrest and oxidative damage. The protocol still needs further optimization, and there are still some unknown factors in prepubertal rat testes transplantation.


Author(s):  
A Rajaraman

Abstract: The history of any art is the basic nail root. In ancient times humans were first seen as the basis of omens and then began to worship the planets as deities due to the effects of the rages of nature. They then began to observe the changes in nature caused by the planets and the consequences. As a result of such research, the planets Sun, Mars and Saturn were divided into evil planets and the planets Moon, Mercury, Guru and Venus were divided into virtuous planets. Based on this they have been doing continuous study of people for centuries. The effects of planetary influences on this planet were first seen only by nations and kings, and then gradually benefited an individual. The result was a gradual breakdown of the sky, galaxy, and zodiac. Historians believe that the oldest fortune-teller was written on April 29, 410 BC. Going abroad was considered a great achievement and an active activity in the 1970s - 80s. It was considered an act performed only by the affluent. They only went abroad for higher studies and work. Due to the subsequent scientific development and technological development, going abroad has become a very simple thing. Indians got job opportunities abroad through computer and software. The growth of India's current computer industry has made it easier for all people to go abroad. Keywords: Bhakyashtana, Bhakyathipathi, pada, Dasa, Buddhi


Author(s):  
T. V. Tregubchak ◽  
T. V. Bauer ◽  
R. A. Maksyutov ◽  
E. V. Gavrilova

The eradication of smallpox has become one of the greatest successes of modern health science. This great achievement was made possible thanks to the widespread vaccination of the population. The last case of human infection with smallpox virus occurred in 1977. In 1980, at the 33rd session of the World Health Assembly, routine vaccination against that infection was recommended to be discontinued due to severe post-vaccination complications. However, humanity remains vulnerable to other orthopoxvirus infections closely related to smallpox virus. Recently, the cases of human infection with ortopoxviruses such as monkeypox virus, cowpox virus, vaccinia virus have become more frequent. Also, cases of infection of people with previously unknown orthopoxvirus species are recorded. Zoonotic orthopoxviruses pathogenic for humans, circulating in nature, require a detailed study and monitoring of the emergence of new strains. Their occurrence against the background of the cessation of planned vaccination of the population against smallpox virus can lead to the emergence of new highly pathogenic viruses. This review contains information on cases of human infection with orthopoxviruses around the world for the period 2008–2018. It also describes epidemiological anamnesis and the relations between cases of human infection in different countries due to the spread of viruses over a wide area, the movement of people between countries, population contacts with domestic and wild animals. Also, this paper provides information on the infection of people with previously unknown strains of orthopoxviruses.


2021 ◽  
Vol 10 (20) ◽  
pp. 4782
Author(s):  
Shi Chen ◽  
Liang Chen ◽  
Firat Duru ◽  
Shengshou Hu

Arrhythmogenic cardiomyopathy (ACM) is a rare inherited cardiomyopathy characterized as fibro-fatty replacement, and a common cause for sudden cardiac death in young athletes. Development of heart failure (HF) has been an under-recognized complication of ACM for a long time. The current clinical management guidelines for HF in ACM progression have nowadays been updated. Thus, a comprehensive review for this great achievement in our understanding of HF in ACM is necessary. In this review, we aim to describe the research progress on epidemiology, clinical characteristics, risk stratification and therapeutics of HF in ACM.


2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Ognjen Arandjelovic

Democracy is widely praised as a great achievement of humanity. However, in recent years there has been an increasing amount of concern that its functioning across the world may be eroding. In response, efforts to combat such change are emerging. Considering the pervasiveness of technology and its increasing capabilities, it is no surprise that there has been much focus on the use of artificial intelligence(AI) to this end. Questions as to how AI can be best utilized to extend the reach of democracy to currently non-democratic countries, how the involvement in the democratic process of certain demographic groups (e.g. ethnic minorities, women, and young people) can be increased, etc. are frequent topics of discussion. In this article I would like not merely to question whether this is desirable but rather argue that we should be trying to envisage ways of using AI for the exact opposite purpose: that of replacing democratic systems with better alternatives.


2021 ◽  
Vol 11 (3) ◽  
pp. 241-249
Author(s):  
Gundu H. R. Rao

According to one of the earliest definitions, biomedicine means “clinical medicine based on the principles of physiology and biochemistry.” Clinicians for quite some time preferred the use of the term medical research to describe what they considered the clinical findings pertaining to various issues related to clinical studies. Since the time when the basic molecules of life, deoxyribonucleic acids, were characterized and the genetic code elucidated, there has been great excitement, anticipation, and promise for the development of precision and personalized medicine. However, the progress has been considerably slow and at times disappointing. The unprecedented coronavirus disease created a worldwide panic and exposed all our weaknesses and unpreparedness. It also demonstrated a global demand for better public health infrastructure and preparedness to combat future pandemics. This unprecedented public health crisis acted as a great stimulus for putting together a concerted effort to develop vaccines. According to the experts, the time was right and within 48 hours after the information on the SARS-CoV-2 genome was posted, Moderna scientists had on paper a workable mRNA, which would code for the spike protein. The immune engineers at Moderna as well as BioNTech were able to put together a lipid nanoparticle delivery system for safe delivery of this precious cargo to the appropriate cells. Professor Cody Meissner at Tufts University School of Medicine in Boston says, “It is absolutely astonishing that this happened [COVID Vaccine development] in such a short time—to me, it is equivalent to putting a person on the Moon.” It is indeed a great achievement, and it demonstrated the power of basic science and emerging technologies. The extraordinary success of mRNA vaccines has opened new avenues for mRNA-based therapies. mRNAs, siRNAs, and non-coding miRNAs will play a very important role as novel therapeutics soon. Furthermore, this success has acted as a catalyst for ongoing work on the use of small RNAs for therapeutic purposes. Having said that, I must say that there are a great many challenges that need to be addressed.


Author(s):  
Anton Popov ◽  

The article analyzes the process of institutionalization of the Olympic Movement in the Republic of Moldova, as well as the formation of the normative base of great achievement sport and its role as an instrument of foreign policy and a factor of soft power of the Moldovan State. In this regard, the author examines the continuity in the development of sports, in accordance with the two historical and political periods of the Moldovan statehood - "Soviet" and "Post-Soviet", through a comparative analysis of specific sports achievements. In this context, the author examines the main reasons for the slowdown in the development of the Olympic movement, including through the prism of content analysis the leaders of this structure, as well as the admission of systemic errors associated with insufficient funding of Moldovan sports, the lack of a legal framework for sponsoring performance sports, and the loss of the system for training highly qualified coaches.


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