1D alignment of proteins and other nanoparticles by using reversible covalent bonds on cyclic peptide nanotubes

Self-assembling cyclic peptide nanotubes are supramolecular structures whose diameter and external surface properties are precisely controlled. In this communication we describe a general strategy to align different molecules on top...

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The effects of amino acid sequence and solvent polarity on the self-assembling of cyclic peptide nanotubes and molecular channel formation inside the lipid bilayer

Journal of Molecular Liquids ◽

10.1016/j.molliq.2020.113660 ◽

2020 ◽

Vol 314 ◽

pp. 113660

Author(s):

Mohammad Khavani ◽

Mohammad Izadyar ◽

Mohammad Reza Housaindokht

Keyword(s):

Amino Acid ◽

Amino Acid Sequence ◽

Cyclic Peptide ◽

Solvent Polarity ◽

The Self ◽

Channel Formation ◽

Peptide Nanotubes ◽

Self Assembling ◽

Molecular Channel ◽

Cyclic Peptide Nanotubes

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Recent advances in controlling the internal and external properties of self-assembling cyclic peptide nanotubes and dimers

Organic & Biomolecular Chemistry ◽

10.1039/c7ob00351j ◽

2017 ◽

Vol 15 (21) ◽

pp. 4490-4505 ◽

Cited By ~ 38

Author(s):

N. Rodríguez-Vázquez ◽

M. Amorín ◽

J. R. Granja

Keyword(s):

Cyclic Peptide ◽

Peptide Nanotubes ◽

Self Assembling ◽

Recent Advances ◽

Cyclic Peptide Nanotubes

Tuning the internal and external properties of self-assembling cyclic peptide nanotubes.

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Ion Channel Models Based on Self-Assembling Cyclic Peptide Nanotubes

Accounts of Chemical Research ◽

10.1021/ar400061d ◽

2013 ◽

Vol 46 (12) ◽

pp. 2955-2965 ◽

Cited By ~ 193

Author(s):

Javier Montenegro ◽

M. Reza Ghadiri ◽

Juan R. Granja

Keyword(s):

Ion Channel ◽

Cyclic Peptide ◽

Channel Models ◽

Peptide Nanotubes ◽

Self Assembling ◽

Cyclic Peptide Nanotubes

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Transmembrane Self-Assembled Cyclic Peptide Nanotubes Based on α‐Residues and Cyclic δ‐Amino Acids: A Computational Study

Frontiers in Chemistry ◽

10.3389/fchem.2021.704160 ◽

2021 ◽

Vol 9 ◽

Author(s):

Alexandre Blanco-González ◽

Martín Calvelo ◽

Pablo F. Garrido ◽

Manuel Amorín ◽

Juan R. Granja ◽

...

Keyword(s):

Amino Acids ◽

Cyclic Peptides ◽

Cyclic Peptide ◽

Computational Study ◽

Peptide Nanotubes ◽

Peptide Motifs ◽

Self Assembling ◽

Transmembrane Channels ◽

Dynamics Simulations ◽

Cyclic Peptide Nanotubes

Self-assembling cyclic peptide nanotubes have been shown to function as synthetic, integral transmembrane channels. The combination of natural and nonnatural aminoacids in the sequence of cyclic peptides enables the control not only of their outer surface but also of the inner cavity behavior and properties, affecting, for instance, their permeability to different molecules including water and ions. Here, a thorough computational study on a new class of self-assembling peptide motifs, in which δ-aminocycloalkanecarboxylic acids are alternated with natural α-amino acids, is presented. The presence of synthetic δ-residues creates hydrophobic regions in these α,δ-SCPNs, which makes them especially attractive for their potential implementation in the design of new drug or diagnostic agent carrier systems. Using molecular dynamics simulations, the behavior of water molecules, different ions (Li+, Na+, K+, Cs+, and Ca2+), and their correspondent counter Cl− anions is extensively investigated in the nanoconfined environment. The structure and dynamics are mutually combined in a diving immersion inside these transmembrane channels to discover a fascinating submarine nanoworld where star-shaped water channels guide the passage of cations and anions therethrough.

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