scholarly journals Plasmon-Enhanced Theranostic Nanoplatform for Synergistic Chemo-Phototherapy of Hypoxic Tumors in the NIR-II Window

2021 ◽  
Author(s):  
Ming-Ming Chen ◽  
Hai-Li Hao ◽  
Wei Zhao ◽  
Xueli Zhao ◽  
Hong-Yuan Chen ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Therapeutic Modalities

Development of simple and effective synergistic therapy by combination of different therapeutic modalities within one single nanostructure is of great importance for cancer treatment. In this study, by integrating the...

Thrombotic Microangiopathy in Cancer

2019 ◽  
Vol 45 (04) ◽  
pp. 348-353 ◽  
Author(s):  
Ilene Ceil Weitz
Keyword(s):  
Platelet Count ◽  
Cancer Treatment ◽  
Hemolytic Anemia ◽  
Cancer Chemotherapy ◽  
Thrombotic Microangiopathy ◽  
Organ Damage ◽  
Microangiopathic Hemolytic Anemia ◽  
Therapeutic Modalities

AbstractThrombotic microangiopathy (TMA) is a rare but often devastating complication of cancer and cancer treatment. The syndrome is defined by thrombocytopenia (i.e., a platelet count of < 150,000/mcL or > 30% decrease from baseline), microangiopathic hemolytic anemia, and some evidence of organ damage. Among the nine recognized groups of disorders causing TMA, the focus of this article will be on cancer and cancer treatment-related causes of TMA. This review will discuss the pathophysiology of TMA in cancer, chemotherapy-associated TMA, transplant-associated TMA, and newer therapeutic modalities.

scholarly journals Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review

2021 ◽  
Vol 9 ◽  
Author(s):  
Zeng Zeng ◽  
Chao Fang ◽  
Ying Zhang ◽  
Cong-Xian Chen ◽  
Yi-Feng Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Treatment ◽  
Therapeutic Agents ◽  
Sonodynamic Therapy ◽  
Therapeutic Modalities ◽  
Normal Functions ◽  
The Past ◽  
Highly Efficient ◽  
Apoptotic Pathways ◽  
Mitochondria Targeting

Mitochondria are the primary organelles which can produce adenosine triphosphate (ATP). They play vital roles in maintaining normal functions. They also regulated apoptotic pathways of cancer cells. Given that, designing therapeutic agents that precisely target mitochondria is of great importance for cancer treatment. Nanocarriers can combine the mitochondria with other therapeutic modalities in cancer treatment, thus showing great potential to cancer therapy in the past few years. Herein, we summarized lipophilic cation- and peptide-based nanosystems for mitochondria targeting. This review described how mitochondria-targeted nanocarriers promoted highly efficient cancer treatment in photodynamic therapy (PDT), chemotherapy, combined immunotherapy, and sonodynamic therapy (SDT). We further discussed mitochondria-targeted nanocarriers’ major challenges and future prospects in clinical cancer treatment.

scholarly journals Phototherapy meets immunotherapy: a win–win strategy to fight against cancer

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Jianhua Zou ◽  
Ling Li ◽  
Zhen Yang ◽  
Xiaoyuan Chen
Keyword(s):  
Cell Death ◽  
Cancer Treatment ◽  
Synergistic Effects ◽  
Metastatic Cancer ◽  
Therapeutic Modality ◽  
Oncological Treatment ◽  
Therapeutic Modalities ◽  
Tumor Metastases ◽  
Antigen Presenting ◽  
Fight Against Cancer

Abstract Phototherapy usually includes photodynamic therapy (PDT) and photothermal therapy (PTT) to induce cell death. PDT utilizes the sensitization of the photosensitizers to generate reactive oxygen species by the intersystem crossing while PTT undergoes nonradiative decay to generate heat. Cancer immunotherapy has evolved as a new therapeutic modality to eradicate tumor cells by activating antigen-presenting cells, and thus, inducing innate or adaptive immune responses. Phototherapy is able to stimulate the immune system, usually by inducing immunogenic cell death (ICD). Photoimmunotherapy (PIT) is an oncological treatment that combines the phototherapy of the tumor with immunotherapy treatment. Combining phototherapy with immunotherapy enhances the immunostimulating response and has synergistic effects for metastatic cancer treatment. PIT is able to enhance the antitumor immune response by ICD and prevent tumor metastases and recurrence. In this review article, we would like to summarize the recent advances in the development of phototherapy (such as PDT, PTT, and synergistic PDT/PTT) triggered immunotherapy for cancer treatment. In addition, immunotherapy triggered by phototherapy and other therapeutic modalities will be discussed. PIT may be a win-win strategy to fight against cancer.

scholarly journals Assessment of the Quality of Life for Gynecologic Cancer Patients Using Functional Assessment of Cancer Therapy-General (Fact-G) Questionnaire at Haji Adam Malik Hospital

2019 ◽  
Vol 7 (16) ◽  
pp. 2569-2573 ◽  
Author(s):  
Deri Edianto ◽  
Muhammad Rizki Yaznil ◽  
Ade Ayu Chartyansari ◽  
Iman Helmi Effendi
Keyword(s):  
Quality Of Life ◽  
Cancer Treatment ◽  
Cancer Patients ◽  
Gynecologic Cancer ◽  
High Morbidity ◽  
Social Emotional ◽  
Duration Of Treatment ◽  
Therapeutic Modalities ◽  
General Fact

BACKGROUND: Nowadays, successful treatment of cancer is not only measured by 5-years survival rate, but also by the patient’s quality of life (QOL). Delayed in the seeking of cancer treatment resulted in high morbidity and impact on the quality of life. AIM: This study aims to assess the QOL of patients with gynecologic cancer after therapy. The results of this research can be used as a basis for cancer treatment that should be holistic, not only to eradicate the disease, but also improve QOL. METHODS: A total of 47 respondents who went to the Department of Oncology, Haji Adam Malik Hospital Medan from May to October 2015 were asked to fill out the FACT-G questionnaire for the QOL assessment. The patient’s personal and disease data was taken from the medical records. The data were analysed statistically by one-way ANOVA test. RESULTS: The results showed that the physical, social, emotional and functional of cancer patients were not much different based on the variables studied. The QOL was higher in patients with endometrial cancer compared with other types of cancer. The QOL was also higher in patients who had completed treatment (> 6 months) and early-stages cancer. There was no statistical difference between the QOL of patients with gynecologic cancer based on therapeutic modalities, duration of treatment and the stage of disease (p > 0.05). CONCLUSION: This current study found the QOL, physical, and emotional complaints are still encountered.

1077: A Novel Apoptosis-Inducing Gene and its Application in Prostate Cancer Treatment

2004 ◽  
Vol 171 (4S) ◽  
pp. 284-284
Author(s):  
Yi Lu ◽  
Jun Zhang ◽  
Ben Beheshti ◽  
Ximing J. Yang ◽  
Syamal K. Bhattacharya ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Treatment ◽  
Prostate Cancer Treatment

Molecular Mechanism of Apoptosis Induction by Resveratrol, a Natural Cancer Chemopreventive Agent

2008 ◽  
Vol 78 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Fan ◽  
Jiang ◽  
Zhang ◽  
Bai
Keyword(s):  
Cancer Treatment ◽  
Molecular Mechanism ◽  
Apoptosis Induction ◽  
Protective Agents ◽  
Chemopreventive Agent ◽  
Naturally Occurring ◽  
Apoptosis Pathways ◽  
Present Understanding

In efforts to identify naturally occurring compounds that act as protective agents, resveratrol, a phytoalexin existing in wine, has attracted much interest because of its diverse pharmacological characteristics. Considering that apoptosis induction is the most potent defense approach for cancer treatment, we have tried to summarize our present understanding of apoptosis induction by resveratrol based on the two major apoptosis pathways.

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