scholarly journals Dynamic supramolecular self-assembly of platinum(ii) complexes perturbs an autophagy–lysosomal system and triggers cancer cell death

2021 ◽  
Author(s):  
Ka-Chung Tong ◽  
Pui-Ki Wan ◽  
Chun-Nam Lok ◽  
Chi-Ming Che
Keyword(s):  
Cell Death ◽  
Cancer Cell ◽  
Self Assembly ◽  
Cancer Cell Death ◽  
Enzymatic Action ◽  
Lysosomal System

Self-assembly of platinum(ii) glycosylated arylacetylide gave transformable superstructures upon enzymatic action in cellulo, leading to perturbation of an autophagy-lysosomal system and cancer cell death.

scholarly journals Self-assembly of mitochondria-specific peptide amphiphiles amplifying lung cancer cell death through targeting the VDAC1–hexokinase-II complex

2019 ◽  
Vol 7 (30) ◽  
pp. 4706-4716 ◽  
Author(s):  
Dan Liu ◽  
Angelina Angelova ◽  
Jianwen Liu ◽  
Vasil M. Garamus ◽  
Borislav Angelov ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Death ◽  
Cancer Cell ◽  
Self Assembly ◽  
Cell Penetrating Peptides ◽  
Lung Cancer Cell ◽  
Hexokinase Ii ◽  
Cancer Cell Death ◽  
Cell Penetrating ◽  
Specific Peptide

Novel cell-penetrating peptides self-assemble into ellipsoid-shape nanostructures which amplified the apoptotic stimuli by weakening the VDAC1–HK-II interaction.

Cancer Cell Death Induced by the Intracellular Self-Assembly of an Enzyme-Responsive Supramolecular Gelator

2015 ◽  
Vol 137 (2) ◽  
pp. 770-775 ◽  
Author(s):  
Akiko Tanaka ◽  
Yuki Fukuoka ◽  
Yuka Morimoto ◽  
Takafumi Honjo ◽  
Daisuke Koda ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cell ◽  
Self Assembly ◽  
Cancer Cell Death

scholarly journals Selectively Inducing Cancer Cell Death by Intracellular Enzyme-Instructed Self-Assembly (EISA) of Dipeptide Derivatives

2017 ◽  
Vol 6 (15) ◽  
pp. 1601400 ◽  
Author(s):  
Jie Li ◽  
Junfeng Shi ◽  
Jamie E. Medina ◽  
Jie Zhou ◽  
Xuewen Du ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cell ◽  
Self Assembly ◽  
Intracellular Enzyme ◽  
Cancer Cell Death

New Insight into 2-Methoxyestradiol- a Possible Physiological Link between Neurodegeneration and Cancer Cell Death

2016 ◽  
Vol 23 (15) ◽  
pp. 1513-1527 ◽  
Author(s):  
Magdalena Gorska ◽  
Alicja Kuban-Jankowska ◽  
Jaroslaw Slawek ◽  
Michal Wozniak
Keyword(s):  
Cell Death ◽  
Cancer Cell ◽  
Cancer Cell Death ◽  
Insight Into

Zinc chelator TPEN induces pancreatic cancer cell death through causing oxidative stress and inhibiting cell autophagy

2019 ◽  
Vol 234 (11) ◽  
pp. 20648-20661 ◽  
Author(s):  
Zhen Yu ◽  
Ze Yu ◽  
ZhenBao Chen ◽  
Lin Yang ◽  
MingJun Ma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pancreatic Cancer ◽  
Cell Death ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Death ◽  
Zinc Chelator

Magneto Mitochondrial Dysfunction Mediated Cancer Cell Death Using Intracellular Magnetic Nano-Transducers

2021 ◽  
Author(s):  
Wooram Park ◽  
Seok-Jo Kim ◽  
Paul Cheresh ◽  
Jeanho Yun ◽  
Byeongdu Lee ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Therapy ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Cancer Cell ◽  
High Sensitivity ◽  
Intrinsic Pathway ◽  
Cancer Cell Death

Mitochondria are crucial regulators of the intrinsic pathway of cancer cell death. The high sensitivity of cancer cells to mitochondrial dysfunction offers opportunities for emerging targets in cancer therapy. Herein,...

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