Biomineralized iron oxide–polydopamine hybrid nanodots for contrast-enhanced T1-weighted magnetic resonance imaging and photothermal tumor ablation

2021 ◽  
Vol 9 (7) ◽  
pp. 1781-1786
Author(s):  
Ze’ai Wang ◽  
Yanfeng Wang ◽  
Yuan Wang ◽  
Chaogang Wei ◽  
Yibin Deng ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Therapeutic Efficacy ◽  
Tumor Ablation ◽  
Resonance Imaging ◽  
Contrast Enhanced ◽  
Weighted Magnetic Resonance Imaging

Biomineralized iron oxide–polydopamine hybrid nanodots are constructed using albumin nanoreactors to facilitate contrast-enhanced T1-weighted magnetic resonance imaging as well as photothermal therapeutic efficacy.

Iron-oxide-based twin nanoplates with strong T2 relaxation shortening for contrast-enhanced magnetic resonance imaging

Nanoscale ◽  
2018 ◽  
Vol 10 (38) ◽  
pp. 18398-18406 ◽  
Author(s):  
Ruixue Wei ◽  
Tiantian Zhou ◽  
Chengjie Sun ◽  
Hongyu Lin ◽  
Lijiao Yang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Tumor Imaging ◽  
Resonance Imaging ◽  
T2 Relaxation ◽  
Contrast Enhanced

Iron oxide twin nanoplates with high T2 relaxivity for in vivo contrast-enhanced magnetic resonance imaging and tumor imaging were reported.

Numerical Study of Transport of Anticancer Drugs in Heterogeneous Vasculature of Human Brain Tumors Using Dynamic Contrast Enhanced-Magnetic Resonance Imaging

2018 ◽  
Vol 140 (5) ◽  
Author(s):  
Ajay Bhandari ◽  
Ankit Bansal ◽  
Anup Singh ◽  
Niraj Sinha
Keyword(s):  
Magnetic Resonance Imaging ◽  
Experimental Data ◽  
Magnetic Resonance ◽  
Brain Tumors ◽  
Human Brain ◽  
Therapeutic Efficacy ◽  
Free Drug ◽  
Resonance Imaging ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

Systemic administration of drugs in tumors is a challenging task due to unorganized microvasculature and nonuniform extravasation. There is an imperative need to understand the transport behavior of drugs when administered intravenously. In this study, a transport model is developed to understand the therapeutic efficacy of a free drug and liposome-encapsulated drugs (LED), in heterogeneous vasculature of human brain tumors. Dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) data is employed to model the heterogeneity in tumor vasculature that is directly mapped onto the computational fluid dynamics (CFD) model. Results indicate that heterogeneous vasculature leads to preferential accumulation of drugs at the tumor position. Higher drug accumulation was found at location of higher interstitial volume, thereby facilitating more tumor cell killing at those areas. Liposome-released drug (LRD) remains inside the tumor for longer time as compared to free drug, which together with higher concentration enhances therapeutic efficacy. The interstitial as well as intracellular concentration of LRD is found to be 2–20 fold higher as compared to free drug, which are in line with experimental data reported in literature. Close agreement between the predicted and experimental data demonstrates the potential of the developed model in modeling the transport of LED and free drugs in heterogeneous vasculature of human tumors.

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