Hydrophilic magnetic covalent triazine frameworks fishing for differential N-glycopeptides in breast cancer plasma membrane

2022 ◽  
Author(s):  
Zhiyu Li ◽  
Yichun Gao ◽  
Huinan Zhang ◽  
Fang Lan ◽  
Yao Wu
Keyword(s):  
Breast Cancer ◽  
Plasma Membrane ◽  
Membrane Glycoproteins ◽  
Hallmarks Of Cancer

The alterations in plasma membrane glycoproteins (PMGs) have been identified as the hallmarks of cancer. The comparison and identification of differential PMGs is significant for finding new markers and understanding...

Biological Role of CDK 11 and 12 in Cell Cycle and its Function in Tumorigenesis

2020 ◽  
Author(s):  
Shamim Mushtaq
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Web Of Science ◽  
The Body ◽  
Main Role ◽  
Hallmarks Of Cancer ◽  
Cyclin Dependent Kinases ◽  
Tumor Studies ◽  
Cycle Regulation

Uninhibited proliferation and abnormal cell cycle regulation are the hallmarks of cancer. The main role of cyclin dependent kinases is to regulate the cell cycle and cell proliferation. These protein kinases are frequently down regulated or up regulated in various cancers. Two CDK family members, CDK 11 and 12, have contradicting views about their roles in different cancers. For example, one study suggests that the CDK 11 isoforms, p58, inhibits growth of breast cancer whereas, the CDK 11 isoform, p110, is highly expressed in breast tumor. Studies regarding CDK 12 show variation of opinion towards different parts of the body, however there is a consensus that upregulation of cdk12 increases the risk of breast cancer. Hence, CDK 11 and CDK 12 need to be analyzed to confirm their mechanism and their role regarding therapeutics, prognostic value, and ethnicity in cancer. This article gives an outline on both CDKs of information known up to date from Medline, PubMed, Google Scholar and Web of Science search engines, which were explored and thirty relevant researches were finalized.

scholarly journals Biogenesis of plasma membrane glycoproteins in hepatoma tissue culture cells.

1978 ◽  
Vol 253 (3) ◽  
pp. 965-973 ◽  
Author(s):  
D. Doyle ◽  
H. Baumann ◽  
B. England ◽  
E. Friedman ◽  
E. Hou ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Plasma Membrane ◽  
Membrane Glycoproteins ◽  
Culture Cells ◽  
Tissue Culture Cells ◽  
Hepatoma Tissue

Fucose incorporation into synaptic mitochondrial and plasma-membrane glycoproteins

1980 ◽  
Vol 8 (5) ◽  
pp. 619-620 ◽  
Author(s):  
CHRISTOPHER J. BRANFORD WHITE ◽  
DEBRA J. MULLINS
Keyword(s):  
Plasma Membrane ◽  
Membrane Glycoproteins

scholarly journals Glycosylation Modulates Plasma Membrane Trafficking of CD24 in Breast Cancer Cells

2021 ◽  
Vol 22 (15) ◽  
pp. 8165
Author(s):  
Amanda Chantziou ◽  
Kostas Theodorakis ◽  
Hara Polioudaki ◽  
Eelco de Bree ◽  
Marilena Kampa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Plasma Membrane ◽  
Subcellular Localization ◽  
Cancer Cells ◽  
Membrane Trafficking ◽  
Breast Cancer Cells ◽  
Endocytic Pathway ◽  
Cell Periphery ◽  
Wild Type ◽  
Mcf 7

In breast cancer, expression of Cluster of Differentiation 24 (CD24), a small GPI-anchored glycoprotein at the cell periphery, is associated with metastasis and immune escape, while its absence is associated with tumor-initiating capacity. Since the mechanism of CD24 sorting is unknown, we investigated the role of glycosylation in the subcellular localization of CD24. Expression and localization of wild type N36- and/or N52-mutated CD24 were analyzed using immunofluorescence in luminal (MCF-7) and basal B (MDA-MB-231 and Hs578T) breast cancer cells lines, as well as HEK293T cells. Endogenous and exogenously expressed wild type and mutated CD24 were found localized at the plasma membrane and the cytoplasm, but not the nucleoplasm. The cell lines showed different kinetics for the sorting of CD24 through the secretory/endocytic pathway. N-glycosylation, especially at N52, and its processing in the Golgi were critical for the sorting and expression of CD24 at the plasma membrane of HEK293T and basal B type cells, but not of MCF-7 cells. In conclusion, our study highlights the contribution of N-glycosylation for the subcellular localization of CD24. Aberrant N-glycosylation at N52 of CD24 could account for the lack of CD24 expression at the cell surface of basal B breast cancer cells.

Fractionation and identification of pig lymph node plasma membrane glycoproteins

1982 ◽  
Vol 19 (2) ◽  
pp. 201-217 ◽  
Author(s):  
Brian H. Barber ◽  
Sudha Arya
Keyword(s):  
Plasma Membrane ◽  
Lymph Node ◽  
Membrane Glycoproteins

Intracellular Sorting of Plasma Membrane Glycoproteins in Epithelial Cells

1984 ◽  
Vol 435 (1 First Colloqu) ◽  
pp. 337-340
Author(s):  
PEDRO J. I. SALAS ◽  
DORA E. VEGA SALAS ◽  
DAVID MISEK ◽  
ENZO BARD ◽  
ENRIQUE J. RODRIGUEZ-BOULAN
Keyword(s):  
Plasma Membrane ◽  
Epithelial Cells ◽  
Membrane Glycoproteins ◽  
Intracellular Sorting
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