Abstract:
Among the large variety of nitrogen and oxygen heterocycles, 1,3,4-oxadiazole, the scaffold, has attracted considerable attention owing to its ability to showing an extensive range of pharmacological actions. Therefore, significant efforts of organic chemists have been directed towards the construction of new drug candidates containing 1,3,4-oxadiazole subunits connected to a known pharmaceutical or a potential pharmacophore. This digest highlights recent publications on the various synthesis techniques of 1,3,4-oxadiazole and related compounds over the previous ten years (2011–2021). The purpose of this review is to learn about several ways for synthesizing oxadiazole. These heterocyclics are formed mainly by the cyclization reactions of various reactants under diverse circumstances. According to the literature investigations, they were given a high priority for their pharmacological significance, such as anticonvulsant, anticancer, antioxidant, anti-inflammatory, antibacterial, antidiabetic, etc.
