Comprehensive Review on Synthetic Approaches and Biological Activities of 1,3,4-Oxadiazole

Among the large variety of nitrogen and oxygen heterocycles, 1,3,4-oxadiazole, the scaffold, has attracted considerable attention owing to its ability to showing an extensive range of pharmacological actions. Therefore, significant efforts of organic chemists have been directed towards the construction of new drug candidates containing 1,3,4-oxadiazole subunits connected to a known pharmaceutical or a potential pharmacophore. This digest highlights recent publications on the various synthesis techniques of 1,3,4-oxadiazole and related compounds over the previous ten years (2011–2021). The purpose of this review is to learn about several ways for synthesizing oxadiazole. These heterocyclics are formed mainly by the cyclization reactions of various reactants under diverse circumstances. According to the literature investigations, they were given a high priority for their pharmacological significance, such as anticonvulsant, anticancer, antioxidant, anti-inflammatory, antibacterial, antidiabetic, etc.

New classes of graphs with edge $ \; \delta- $ graceful labeling

<abstract><p>Graph labeling is a source of valuable mathematical models for an extensive range of applications in technologies (communication networks, cryptography, astronomy, data security, various coding theory problems). An edge $ \; \delta - $ graceful labeling of a graph $ G $ with $ p\; $ vertices and $ q\; $ edges, for any positive integer $ \; \delta $, is a bijective $ \; f\; $ from the set of edge $ \; E(G)\; $ to the set of positive integers $ \; \{ \delta, \; 2 \delta, \; 3 \delta, \; \cdots\; , \; q\delta\; \} $ such that all the vertex labels $ \; f^{\ast} [V(G)] $, given by: $ f^{\ast}(u) = (\sum\nolimits_{uv \in E(G)} f(uv)\; )\; mod\; (\delta \; k) $, where $ k = max (p, q) $, are pairwise distinct. In this paper, we show the existence of an edge $ \; \delta- $ graceful labeling, for any positive integer $ \; \delta $, for the following graphs: the splitting graphs of the cycle, fan, and crown, the shadow graphs of the path, cycle, and fan graph, the middle graphs and the total graphs of the path, cycle, and crown. Finally, we display the existence of an edge $ \; \delta- $ graceful labeling, for the twig and snail graphs.</p></abstract>

Recent updates on Synthetic Strategies and Biological Potential of 1,3,4-oxadiazole: Review

Among the large variety of nitrogen and oxygen-containing heterocycles, 1,3,4-oxadiazole, the scaffold, has attracted considerable attention owing to its ability to show an extensive range of pharmacological actions. According to literature investigations, prepared 1,3,4-oxadiazole and its derivative are pharmacologically significant and consist of a variety of activities, such as anticonvulsant, anticancer, antioxidant, anti-inflammatory, antibacterial, antidiabetic, etc. These heterocyclics are formed mainly by the cyclization reactions of various reactants under diverse reaction circumstances. Therefore, significant efforts of organic chemists have been directed towards the synthesis of new drug candidates containing 1,3,4-oxadiazole subunits connected to an established potential pharmacophore to improve the efficacy and potency. This article aims to highlight recent publications on the various synthesis techniques of 1,3,4-oxadiazole and related compounds over the previous ten years (2011–2021). The purpose of this review is to help researchers by summarizing several synthetic strategies for synthesizing oxadiazole.

Recent advances in the synthesis of benzothiazole and its derivatives

Benzothiazoles have recognized pharmacophores in the field of research, predominantly in synthetic and medicinal chemistry, on account of their significant pharmaceutical properties. This important class of derivatives endows an extensive range of biological activities like anti-inflammatory, antidiabetic, anticancer, anticonvulsant, antibacterial, antiviral, antioxidant, antituberculosis, enzyme inhibitors, etc. Hence, various methodologies have been accomplished to synthesize benzothiazole compounds considering the purity, yield, and selectivity of the products. This review provides different reaction methods that are involved in the synthesis of a variety of benzothiazole derivatives.

Concept Creep and Psychiatrization

Some aspects of psychiatrization can be understood as forms of concept creep, the progressive expansion of concepts of harm. This article compares the two concepts and explores how concept creep sheds light on psychiatrization. We argue that although psychiatrization is in some respects a broader concept than concept creep, addressing institutional and societal dimensions of the expanding reach of psychiatry in addition to conceptual change, concept creep is broader in other respects, viewing the expansion of psychiatric concepts as examples of the broadening of a more extensive range of harm-related concepts. A concept creep perspective on psychiatrization clarifies the different forms of expansion it involves, the centrality of harm to it, its benefits as well as its costs, its variations across individuals and groups, and the drivers of psychiatrization in the general public and in fields beyond psychiatry.

Visual imagery vividness declines across the lifespan

The capacity to elicit vivid visual mental images varies within an extensive range across individuals between hyper- and aphantasia. It is not clear, however, whether imagery vividness is constant across the lifespan or changes during development and later in life. Without enforcing the constraints of strict experimental procedures and representativity across the entire population, our purpose was to take a first look at the self-reported level of imagery vividness and determine the relative proportion of aphantasic/hyperphantasic participants in different age-groups. Relying on the frequently used Vividness of Visual Mental Imagery questionnaire, we collected data on a random sample of 2252 participants between the ages of 12 to 60 years. We found a novel developmental pattern describing a declining ability to elicit vivid visual mental images in the group averages of different age-groups from adolescence to middle age. This effect involves both a decreasing proportion of individuals with very vivid imagery and an increasing proportion of individuals with weak imagery as maturation (assessed by boneage estimations in adolescents) and aging progresses. This finding may help to shed light on yet unknown developmental mechanisms of our internal, stimulus-independent processes, and might also help to determine genetic, maturational, and age-dependent factors in the extreme cases of hyper- and aphantasia.

Study on the Effectiveness of Simultaneous Recovery and Concentration of 1-Ethyl-3-methylimidazolium Chloride Ionic Liquid by Electrodialysis with Heterogeneous Ion-Exchange Membranes

Due to the extensive range of ionic liquids (ILs) used in industry, an efficient recovery method is needed. In this study, the effectiveness of a simultaneous concentration and recovery method was investigated for 1-ethyl-3-methylimidazolium chloride ([Emim]Cl), an IL that was recovered using electrodialysis (ED). The optimal operational parameters for electrodialytic recovery were determined empirically. The variables that were investigated included the concentration of IL, applied voltage, linear flow velocity and the diluate-to-concentrate volume ratio. The recovery of [Emim]Cl, the concentration degree, the [Emim]Cl flux across membranes, the current efficiency, as well as the energy consumption were determined. The results of the experiments confirmed that [Emim]Cl concentration and recovery can be achieved using ED. The highest ED efficiency was obtained when a 2 V electric potential per one membrane pair was applied, using a 2 cm/s linear flow velocity, and by adjusting to 0.2 M IL in the feed solution. By using ED, a 2.35-fold concentration of [Emim]Cl with a recovery of 90.4% could be achieved when the diluate-to-concentrate volume ratio was 2. On the other hand, a 3.35-fold concentration of [Emim]Cl with a recovery of 81.7% could be obtained when the diluate-to-concentrate volume ratio was increased to 5.

RUSSIAN SPACE THROUGH THE PRISM OF LONG-TERM ACADEMIC INTERDISCIPLINARY RESEARCH(REFLECTIONS ON THE BOOK «CHALLENGES AND POLICY OF RUSSIA’S SPATIAL DEVELOPMENT IN THE 21ST CENTURY»)

The article contains the author’s reflections on the scientific, theoretical and applied aspects of the modern challenges of Russia’s spatial development and the state policy responding to them, its goals and tools. The reason for the appearance of these reflections was the recent publication of a scientific and academic collective monograph on this topic, and their subject basis was an extensive range of issues analyzed in this monograph. In his reflections on the book, the author strives to identify, first of all, scientific results that are of a pioneering and debatable nature, while avoiding making categorical assessments and formulating final conclusions about complex and ambiguous judgments presented on the pages of the book. The author does not try to comment equally on all sections and aspects of a voluminous monograph, but focuses on revealing the ideological richness and meaningful depth of the peer-reviewed collective work, supporting and criticizing, developing and supplementing its most important and controversial provisions.

MicroRNA-214 in Health and Disease

MicroRNAs (miRNAs) are endogenously expressed, non-coding RNA molecules that mediate the post-transcriptional repression and degradation of mRNAs by targeting their 3′ untranslated region (3′-UTR). Thousands of miRNAs have been identified since their first discovery in 1993, and miR-214 was first reported to promote apoptosis in HeLa cells. Presently, miR-214 is implicated in an extensive range of conditions such as cardiovascular diseases, cancers, bone formation and cell differentiation. MiR-214 has shown pleiotropic roles in contributing to the progression of diseases such as gastric and lung cancers but may also confer cardioprotection against excessive fibrosis and oxidative damage. These contrasting functions are achieved through the diverse cast of miR-214 targets. Through silencing or overexpressing miR-214, the detrimental effects can be attenuated, and the beneficial effects promoted in order to improve health outcomes. Therefore, discovering novel miR-214 targets and understanding how miR-214 is dysregulated in human diseases may eventually lead to miRNA-based therapies. MiR-214 has also shown promise as a diagnostic biomarker in identifying breast cancer and coronary artery disease. This review provides an up-to-date discussion of miR-214 literature by describing relevant roles in health and disease, areas of disagreement, and the future direction of the field.

Maori, Biculturalism and the Assemblies of God in New Zealand, 1970 - 2008

<p>This thesis examines the extent to which the New Zealand Assemblies of God, one of the largest and oldest Pentecostal denominations in the country, has fostered participation by Maori, and its success in doing so between 1970 and 2008. From the advent of the Mana Maori renaissance in the 1970s the idea of biculturalism became an important vehicle for Maori aspirations. As part of its broader agenda, the thesis also considers the church's response to this bicultural emphasis. The Assemblies' particular response is analysed in the light of experiences in the mainline denominations and the Apostolic and Destiny churches which either experienced considerable success in attracting Maori participation, or explicitly accommodated the call for a bicultural response using recognised bicultural models. The research is based on the published literature of the Assemblies of God and an extensive range of interviews. These provided detail on the motivations and underlying beliefs that have generated particular responses. The published literature of the other denominations has also been addressed for comparative purposes, along with a range of relevant secondary literature. The Assemblies of God's flexible structure, clarity of teaching, fostering of indigenous leadership and emphasis on local church autonomy, has enabled it to grow rapidly throughout the world. Despite this, and despite the church's emphasis on crosscultural mission, this thesis demonstrates that Maori have not joined the Assemblies of God to the same extent that they have other Pentecostal denominations in New Zealand. It argues that the church has done little to foster Maori participation in the movement, and identifies eight key historical, ideological, and organisational factors that have hindered its ability to do so. In particular, it highlights the significance of the denomination's emphasis on local church autonomy, the absence of any deliberate "mission" to Maori, and the church's multicultural emphasis and historical suspicion of "social justice".</p>