scholarly journals Effect of streptomycin on lipid composition with particular reference to cyclic depsipeptide biosynthesis in Serratia marcescens and other micro-organisms

1970 ◽  
Vol 119 (5) ◽  
pp. 861-869 ◽  
Author(s):  
Margaret A. C. Bermingham ◽  
B. S. Deol ◽  
J. L. Still
Keyword(s):  
Serratia Marcescens ◽  
Total Lipid ◽  
Lipid Composition ◽  
Biosynthetic Pathway ◽  
Nocardia Asteroides ◽  
Cyclic Depsipeptide ◽  
Low Concentrations ◽  
Site Of Action ◽  
Rhodopseudomonas Spheroides ◽  
Micro Organisms

The addition of low concentrations of streptomycin (5–10μg/ml of medium) to Serratia marcescens caused significant alterations in the lipid composition of this organism, but neither growth nor pigmentation was affected. The acetone-soluble cyclic depsipeptides, which comprise on average 15% of the total lipid, were decreased almost to zero and the total lipid phosphorus was more than doubled in the presence of streptomycin. Most of the phospholipid increase was due to an increase in phosphatidylethanolamine. Cyclic depsipeptides were not leached from the cell in the presence of streptomycin, indicating a definite inhibition of the biosynthetic pathway. The effect of streptomycin on the reported peptidolipids of Rhodopseudomonas spheroides, Halobacterium halobium, Nocardia asteroides and Pseudomonas tabaci was investigated. In the case of the only strictly comparable cellular cyclic depsipeptide (that of N. asteroides) the biosynthesis was strongly inhibited by streptomycin, but cell weight was maintained or even slightly increased. A possible mode and site of action of low concentrations of streptomycin on bacterial lipids is discussed.

scholarly journals Some chemical and bacterial characteristics of bottom deposits from lakes and estuaries

1953 ◽  
Vol 51 (2) ◽  
pp. 185-194 ◽  
Author(s):  
L. A. Allen ◽  
J. Grindley ◽  
Eileen Brooks
Keyword(s):  
Bacteriological Examination ◽  
Surface Layers ◽  
Digested Sludge ◽  
Faecal Pollution ◽  
Bottom Deposits ◽  
Low Concentrations ◽  
Different Types ◽  
Different Depths ◽  
Micro Organisms ◽  
Reducing Bacteria

Chemical and bacteriological examination of muds from sources differing widely in the degree of pollution to which they were subject showed great differences in the contents of carbon, nitrogen and sulphide. These differences were not correlated with differences in the severity of faecal pollution. The amount of organic matter available for growth of micro-organisms in the mud of different depths was not reflected in the figures for organic carbon. A convenient index of this factor was obtained by measuring the volume of gas evolved during anaerobic digestion over a prolonged period of incubation. The rate of evolution was increased by the addition of an inoculum of digested sludge from a sewage works.Sulphate-reducing bacteria appeared to be of two different types. In samples of mud from fresh-water lakes much higher counts were usually obtained in a medium containing comparatively low concentrations of inorganic salts and of lactate than in a medium containing much higher concentrations of these constituents. In samples from locations where conditions were more saline the reverse was usually true.Counts of Bact. coli and of Strep, faecalis together probably constitute the best index of faecal pollution in the examination of samples of mud. These organisms are, however, largely confined to the surface layers.

scholarly journals Biosynthetic pathway of .BETA.-methylnorleucine, an antimetabolite produced by Serratia marcescens.

1981 ◽  
Vol 34 (10) ◽  
pp. 1283-1289 ◽  
Author(s):  
MASAKI SUGIURA ◽  
MASAHIKO KISUMI ◽  
ICHIRO CHIBATA
Keyword(s):  
Serratia Marcescens ◽  
Biosynthetic Pathway

scholarly journals AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: interference with the Akt/NF-κB survival pathway

Leukemia ◽  
2005 ◽  
Vol 19 (4) ◽  
pp. 572-579 ◽  
Author(s):  
E Escobar-Díaz ◽  
E M López-Martín ◽  
M Hernández del Cerro ◽  
A Puig-Kroger ◽  
V Soto-Cerrato ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Serratia Marcescens ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Cyclic Depsipeptide ◽  
Survival Pathway

THE INFLUENCE OF GONADAL HORMONES ON THE UPTAKE OF [14C]ACETATE BY LIVER LIPID FRACTIONS IN THE IMMATURE MALE CHICK

1968 ◽  
Vol 42 (1) ◽  
pp. 119-127 ◽  
Author(s):  
D. BALNAVE
Keyword(s):  
Lipid Composition ◽  
Biosynthetic Pathway ◽  
Liver Lipid ◽  
Gonadal Hormones ◽  
Liver Lipids ◽  
Triglyceride Fraction ◽  
Lipid Fractions ◽  
Time Patterns ◽  
Male Chick ◽  
Synthesis And Degradation

SUMMARY Six-week-old cockerels with an equalized food intake and receiving by injection oestrogen, androgen or progesterone were used in an investigation on the influence of the gonadal hormones on the rate of uptake of [14C]acetate into liver lipid fractions. The results obtained indicate that oestrogen was the only one of these hormones that affected the overall lipid composition of the liver significantly. However, although in all these treatments most of the label was incorporated into the triglyceride fraction, both testosterone and progesterone showed incorporation-time patterns which differed substantially from those obtained in control and oestrogen-treated birds. There was a very rapid incorporation of label into the liver lipids of the testosterone and progesterone-treated birds and the amount incorporated was greater than the maximum incorporation obtained at a later time in the control or oestrogen-treated birds. It is possible that a different biosynthetic pathway is utilized in the formation of triglycerides in testosterone and progesterone-treated birds than in oestrogen-treated birds. The results indicate also that although testosterone and progesterone do not influence the overall lipid composition of the liver, they exert a significant influence on metabolic processes involving the synthesis and degradation of liver lipids.

Total lipid and fatty acid composition of brill eggs Scophthalmus rhombus L. relationship between lipid composition and egg quality

2010 ◽  
Vol 42 (7) ◽  
pp. 1011-1025 ◽  
Author(s):  
Ismael Hachero Cruzado ◽  
Marcelino Herrera ◽  
Daniel Quintana ◽  
Ana Rodiles ◽  
José I. Navas ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Total Lipid ◽  
Lipid Composition ◽  
Egg Quality

Ozonation by-products issued from the destruction of microorganisms present in wastewaters treated for reuse

2004 ◽  
Vol 50 (2) ◽  
pp. 187-193 ◽  
Author(s):  
M.N. Rojas-Valencia ◽  
M.T. Orta-de-Velásquez ◽  
M. Vaca-Mier ◽  
V. Franco
Keyword(s):  
Amino Acids ◽  
Ascaris Suum ◽  
Correlation Coefficients ◽  
Salmonella Typhi ◽  
Faecal Coliforms ◽  
Excellent Correlation ◽  
Low Concentrations ◽  
Micro Organisms ◽  
By Products ◽  
Cellular Lysis

This work demonstrates the reaction of ozone on the amino acids comprising the covering layer of resistant micro-organisms. A secondary aim was to check the byproducts generated when ozone was applied to synthetic samples (such as Vibrio cholerae NO 01 WFCC-449, Salmonella typhi ATTC-6539, faecal coliforms and Ascaris suum). The ozone was applied at a concentration of 18.4 mgO3/min at pH 3, for different lengths of time. In the case of bacteria, results showed that, at 8 minutes, the number was reduced to the level of the Official Mexican Standards set for treated water destined for irrigation purposes (1,000 MPN/100 mL). Excellent correlation coefficients (0.95 to 0.99) were obtained for microbial concentrations versus ozone contact time. Destruction times required for 100% removal of the initial bacteria population varied between 2 and 14 minutes, while Ascaris suum required 1 hour. When Gram-negative bacteria die due to the effects of ozone, cellular lysis and the liberation of endotoxins (biodegradable) were observed. The ozonation of amino acids in the shell of Ascaris suum eggs, leads to the formation of aldehydes, such as formaldehyde and acetaldehyde, in low concentrations (0.0003 and 0.0005 μg/mL respectively). These levels are not hazardous to human health.

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