Trace analysis of methylated and hydroxymethylated cytosines in DNA by isotope-dilution LC–MS/MS: first evidence of DNA methylation in Caenorhabditis elegans
Keyword(s):
We developed an online solid-phase extraction LC–MS/MS method to simultaneously measure 5-methyl-2′-deoxycytidine and 5-hydroxymethyl-2′-deoxycytidine in DNA. We demonstrated that 5-methyl-2′-deoxycytidine is present in Caenorhabditis elegans and its level was regulated by decitabine or cadmium in a dose–response manner.
2013 ◽
Vol 236
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pp. 919-929
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2018 ◽
Vol 34
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pp. 893-898
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2014 ◽
Vol 113
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pp. 69-76
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1994 ◽
Vol 350
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pp. 150-154
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Vol 1423
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pp. 124-135
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2016 ◽
Vol 88
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pp. 6789-6796
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Vol 90
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pp. 3174-3182
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2017 ◽
pp. 362-371
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