scholarly journals Loss of protein targeting to glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell death

2015 ◽  
Vol 35 (3) ◽  
Author(s):  
Rongqiang Yang ◽  
Mei Zhang ◽  
Amber Renee Gustafson ◽  
Eugenia Wang ◽  
Marsha Paulette Cole ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Protein Targeting ◽  
Glucose Deprivation ◽  
Carcinoma Cells ◽  
Glycogen Accumulation ◽  
Liver Cancer Cells ◽  
Human Hepatocellular Carcinoma Cells ◽  
And Oxidative Stress

PTG is a protein that is critical for glycogen accumulation in various tissues such as the liver. Our present study shows that its loss sensitizes liver cancer cells towards metabolic and oxidative stress.

scholarly journals Autophagy and autophagy dysfunction contribute to apoptosis in HepG2 cells exposed to nanosilica

2016 ◽  
Vol 5 (3) ◽  
pp. 871-882 ◽  
Author(s):  
Yongbo Yu ◽  
Junchao Duan ◽  
Yang Yu ◽  
Yang Li ◽  
Yang Zou ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Hepg2 Cells ◽  
Carcinoma Cells ◽  
Human Hepatocellular Carcinoma ◽  
Hepatocellular Carcinoma Cells ◽  
Icr Mice ◽  
Distinct Cell ◽  
Human Hepatocellular Carcinoma Cells

The present study investigated both autophagy and apoptosis in ICR mice and Human hepatocellular carcinoma cells (HepG2), and then explored the interactive mechanism between these two distinct cell death modalities in HepG2 cells.

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