The role of ion content and cell volume in insulin action

1994 ◽  
Vol 22 (2) ◽  
pp. 516-522 ◽  
Author(s):  
Loranne Agius ◽  
Matthew Peak ◽  
Guy Beresford ◽  
Molham Al-Habori ◽  
Trevor H. Thomas
Keyword(s):  
Cell Volume ◽  
Insulin Action ◽  
Ion Content

Liver cell hydration and integrin signaling

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Michele Bonus ◽  
Dieter Häussinger ◽  
Holger Gohlke
Keyword(s):  
Cell Volume ◽  
Liver Cell ◽  
Cell Function ◽  
The Other ◽  
Signaling Cascades ◽  
Integrin Signaling ◽  
Volume Changes ◽  
The One ◽  
And Oxidative Stress

Abstract Liver cell hydration (cell volume) is dynamic and can change within minutes under the influence of hormones, nutrients, and oxidative stress. Such volume changes were identified as a novel and important modulator of cell function. It provides an early example for the interaction between a physical parameter (cell volume) on the one hand and metabolism, transport, and gene expression on the other. Such events involve mechanotransduction (osmosensing) which triggers signaling cascades towards liver function (osmosignaling). This article reviews our own work on this topic with emphasis on the role of β1 integrins as (osmo-)mechanosensors in the liver, but also on their role in bile acid signaling.

Roles of tyrosine kinase in insulin action on cell volume of fetal rat type II pneumocyte

1996 ◽  
Vol 432 (3) ◽  
pp. 571-573 ◽  
Author(s):  
Yoshinori Marunaka ◽  
Yutaka Shintani ◽  
Eizo Sugimoto ◽  
Naomi Niisato
Keyword(s):  
Tyrosine Kinase ◽  
Cell Volume ◽  
Insulin Action ◽  
Type Ii ◽  
Type Ii Pneumocyte ◽  
Fetal Rat

scholarly journals The role of insulin in the modulation of glucagon-dependent control of phenylalanine hydroxylation in isolated liver cells

1987 ◽  
Vol 242 (3) ◽  
pp. 655-660 ◽  
Author(s):  
M J Fisher ◽  
A J Dickson ◽  
C I Pogson
Keyword(s):  
Cyclic Amp ◽  
Insulin Action ◽  
Phenylalanine Hydroxylase ◽  
Liver Cells ◽  
Phosphorylation State ◽  
Isolated Liver Cells ◽  
The Impact ◽  
Isolated Liver ◽  
Stimulation Of

The stimulation of phenylalanine hydroxylation in isolated liver cells by sub-maximally effective concentrations of glucagon (less than 0.1 microM) is antagonized by insulin (0.1 nM-0.1 microM). This phenomenon is a consequence of a decrease in the glucagon-stimulated phosphorylation of phenylalanine hydroxylase from liver cells incubated in the presence of insulin. The impact of insulin on the phosphorylation state and activity of the hydroxylase is mimicked by incubation of liver cells in the presence of orthovanadate (10 microM). A series of cyclic AMP and cyclic GMP analogues enhanced phenylalanine hydroxylation: in each case insulin diminished the stimulation of flux. These results are discussed in the light of the characteristics of insulin action on other metabolic processes.

Functional role of amino terminus in ClC-3 chloride channel regulation by phosphorylation and cell volume

2006 ◽  
Vol 187 (1-2) ◽  
pp. 5-19 ◽  
Author(s):  
C. F. Rossow ◽  
D. Duan ◽  
W. J. Hatton ◽  
F. Britton ◽  
J. R. Hume ◽  
...  
Keyword(s):  
Cell Volume ◽  
Chloride Channel ◽  
Functional Role ◽  
Amino Terminus ◽  
Channel Regulation

Insulin’s Contribution to Growth in Children and the Potential for Exercise to Mediate Insulin’s Action

1997 ◽  
Vol 9 (1) ◽  
pp. 18-32 ◽  
Author(s):  
Craig A. Horswill ◽  
William B. Zipf ◽  
C. Lawrence Kien ◽  
E. Bowie Kahle
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Insulin Action ◽  
Bone Growth ◽  
Linear Growth ◽  
Amino Acid Uptake ◽  
Acid Uptake ◽  
Healthy Children ◽  
Anabolic Hormone

Insulin is an anabolic hormone with stimulatory effects on glucose and amino acid uptake, possibly protein synthesis, and bone growth, and inhibitory effects on protein breakdown. The precise role of insulin in the growth of healthy children is unclear, but two clinical models can be examined to illustrate insulin’s potential role in the growth of children. The cystic fibrosis (CF) patient, who exhibits poor linear growth and low lean body mass, may exhibit inadequate insulin secretion or impaired insulin action. The obese child typically has an excess of peripheral insulin, an associated acceleration of linear growth, and an accretion of lean body mass and adipose tissue. Speculation is offered on the putative role of exercise in affecting insulin action and secretion, which in turn could impact growth in children with CF or obesity.

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