The functionally diverse roles of tribbles
2013 ◽
Vol 41
(4)
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pp. 1096-1100
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Keyword(s):
Tribbles are members of the pseudokinase family of proteins, with no associated kinase activity detectable to date. As tribbles appear not to function as kinases, there has been debate surrounding their functional classification. Tribbles have been proposed to function as adaptor molecules facilitating degradation of their target proteins. Tribbles have also been proposed to mediate signalling changes to MAPK (mitogen-activated protein kinase) cascades and also to function as decoy kinases interfering with the activity of known kinases. The present review discusses the functionally divergent roles of tribbles as molecular adaptors mediating degradation, changes to signalling cascades and action as decoy kinases.
1996 ◽
Vol 70
(10)
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pp. 6701-6708
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Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase
1993 ◽
Vol 268
(21)
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pp. 16009-16019
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1994 ◽
Vol 269
(22)
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pp. 15756-15761
1993 ◽
Vol 268
(22)
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pp. 16124-16129
2002 ◽
Vol 67
(5)
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pp. 1801-1805
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2000 ◽
Vol 75
(1)
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pp. 11-20
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2010 ◽
Vol 406
(2)
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pp. 233-234
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2004 ◽
Vol 172
(9)
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pp. 5588-5597
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