The Natural History of Hypertension with Moderate Impairment of Renal Function

1. A continuing prospective study of patients with severe hypertension is now in its eighteenth year. 2. Patients with impaired renal function survive longer with present-day management if control of pressure is good and if renal structural abnormalities are not gross. 3. Since 1960 myocardial infarction, rather than cerebrovascular accident, has been the commonest cause of death.

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Diabetic kidney disease: new clinical and therapeutic issues. Joint position statement of the Italian Diabetes Society and the Italian Society of Nephrology on “The natural history of diabetic kidney disease and treatment of hyperglycemia in patients with type 2 diabetes and impaired renal function”

Journal of Nephrology ◽

10.1007/s40620-019-00650-x ◽

2019 ◽

Vol 33 (1) ◽

pp. 9-35 ◽

Cited By ~ 9

Author(s):

Giuseppe Pugliese ◽

◽

Giuseppe Penno ◽

Andrea Natali ◽

Federica Barutta ◽

...

Keyword(s):

Type 2 Diabetes ◽

Renal Function ◽

Kidney Disease ◽

Natural History ◽

Impaired Renal Function ◽

Diabetic Kidney Disease ◽

Italian Society ◽

Diabetic Kidney ◽

History Of

Abstract Aims This joint document of the Italian Diabetes Society and the Italian Society of Nephrology reviews the natural history of diabetic kidney disease (DKD) in the light of the recent epidemiological literature and provides updated recommendations on anti-hyperglycemic treatment with non-insulin agents. Data Synthesis Recent epidemiological studies have disclosed a wide heterogeneity of DKD. In addition to the classical albuminuric phenotype, two new albuminuria-independent phenotypes have emerged, i.e., “nonalbuminuric renal impairment” and “progressive renal decline”, suggesting that DKD progression toward end-stage kidney disease (ESKD) may occur through two distinct pathways, albuminuric and nonalbuminuric. Several biomarkers have been associated with decline of estimated glomerular filtration rate (eGFR) independent of albuminuria and other clinical variables, thus possibly improving ESKD prediction. However, the pathogenesis and anatomical correlates of these phenotypes are still unclear. Also the management of hyperglycemia in patients with type 2 diabetes and impaired renal function has profoundly changed during the last two decades. New anti-hyperglycemic drugs, which do not cause hypoglycemia and weight gain and, in some cases, seem to provide cardiorenal protection, have become available for treatment of these individuals. In addition, the lowest eGFR safety thresholds for some of the old agents, particularly metformin and insulin secretagogues, have been reconsidered. Conclusions The heterogeneity in the clinical presentation and course of DKD has important implications for the diagnosis, prognosis, and possibly treatment of this complication. The therapeutic options for patients with type 2 diabetes and impaired renal function have substantially increased, thus allowing a better management of these individuals.

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A Prospective Study to Evaluate the Natural History of Wounds in Patients With Dystrophic Epidermolysis Bullosa (DEB)

Case Medical Research ◽

10.31525/ct1-nct04214002 ◽

2019 ◽

Author(s):

Keyword(s):

Natural History ◽

Prospective Study ◽

Epidermolysis Bullosa ◽

Dystrophic Epidermolysis Bullosa ◽

History Of ◽

A Prospective Study

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Natural history of left ventricular size and function after acute myocardial infarction. Assessment and prediction by echocardiographic endocardial surface mapping.

Circulation ◽

10.1161/01.cir.82.2.484 ◽

1990 ◽

Vol 82 (2) ◽

pp. 484-494 ◽

Cited By ~ 85

Author(s):

M H Picard ◽

G T Wilkins ◽

P A Ray ◽

A E Weyman

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Natural History ◽

Left Ventricular ◽

Ventricular Size ◽

Surface Mapping ◽

Left Ventricular Size ◽

History Of ◽

Endocardial Surface ◽

And Function

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Clinical characteristics and natural history of patients with acute myocardial infarction sent home from the emergency room

The American Journal of Cardiology ◽

10.1016/0002-9149(87)90217-7 ◽

1987 ◽

Vol 60 (4) ◽

pp. 219-224 ◽

Cited By ~ 462

Author(s):

Thomas H. Lee ◽

Gregory W. Rouan ◽

Monica C. Weisberg ◽

Donald A. Brand ◽

Denise Acampora ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Natural History ◽

Emergency Room ◽

Clinical Characteristics ◽

History Of

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Performance of the Quantitative Food Frequency Questionnaire Used in the Brazilian Center of the Prospective Study Natural History of Human Papillomavirus Infection in Men: The HIM Study

Journal of the American Dietetic Association ◽

10.1016/j.jada.2011.04.006 ◽

2011 ◽

Vol 111 (7) ◽

pp. 1045-1051 ◽

Cited By ~ 9

Author(s):

Juliana Araujo Teixeira ◽

Maria Luiza Baggio ◽

Anna R. Giuliano ◽

Regina Mara Fisberg ◽

Dirce Maria Lobo Marchioni

Keyword(s):

Human Papillomavirus ◽

Natural History ◽

Prospective Study ◽

Food Frequency Questionnaire ◽

Food Frequency ◽

Human Papillomavirus Infection ◽

Papillomavirus Infection ◽

History Of

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Temporal Course of Plasma Trimethylamine N-Oxide (TMAO) Levels in ST-Elevation Myocardial Infarction

Journal of Clinical Medicine ◽

10.3390/jcm10235677 ◽

2021 ◽

Vol 10 (23) ◽

pp. 5677

Author(s):

Mohammad A. Almesned ◽

Femke M. Prins ◽

Erik Lipšic ◽

Margery A. Connelly ◽

Erwin Garcia ◽

...

Keyword(s):

Myocardial Infarction ◽

Renal Function ◽

Infarct Size ◽

Impaired Renal Function ◽

Left Ventricular ◽

St Elevation Myocardial Infarction ◽

Left Ventricular Ejection ◽

Ventricular Ejection Fraction ◽

Temporal Course ◽

St Elevation

The gut metabolite trimethylamine N-oxide (TMAO) at admission has a prognostic value in ST-elevation myocardial infarction (STEMI) patients. However, its sequential changes and relationship with long-term infarct-related outcomes after primary percutaneous coronary intervention (PCI) remain elusive. We delineated the temporal course of TMAO and its relationship with infarct size and left ventricular ejection fraction (LVEF) post-PCI, adjusting for the estimated glomerular filtration rate (eGFR). We measured TMAO levels at admission, 24 h and 4 months post-PCI in 379 STEMI patients. Infarct size and LVEF were determined by cardiac magnetic resonance 4 months after PCI. TMAO levels decreased from admission (4.13 ± 4.37 μM) to 24 h (3.41 ± 5.84 μM, p = 0.001) and increased from 24 h to 4 months (3.70 ± 3.86 μM, p = 0.026). Higher TMAO values at 24 h were correlated to smaller infarct sizes (rho = −0.16, p = 0.024). Larger declines between admission and 4 months suggestively correlated with smaller infarct size, and larger TMAO increases between 24 h and 4 months were associated with larger infarct size (rho = −0.19, p = 0.008 and rho = −0.18, p = 0.019, respectively). Upon eGFR stratification using 90 mL/min/1.73 m2 as a cut-off, significant associations between TMAO and infarct size were only noted in subjects with impaired renal function. In conclusion, TMAO levels in post-PCI STEMI patients are prone to fluctuations, and these fluctuations could be prognostic for infarct size, particularly in patients with impaired renal function.

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