Blood Pressure and Dietary Polyunsaturated and Saturated Fats: A Controlled Trial

1985 ◽  
Vol 69 (2) ◽  
pp. 165-175 ◽  
Author(s):  
Barrie M. Margetts ◽  
Lawrence J. Beilin ◽  
Bruce K. Armstrong ◽  
Ian L. Rouse ◽  
Robert Vandongen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Plasma Lipids ◽  
Controlled Trial ◽  
Saturated Fat ◽  
Vegetarian Diet ◽  
Control Group ◽  
Blood Pressure Lowering Effect ◽  
Diet Records ◽  
Pressure Lowering ◽  
Pressure Changes

1. Fifty-four healthy, omnivore normotensive volunteers aged 20-59 years were randomly allocated either to a control group eating a low polyunsaturated to saturated fat ratio (P/S ratio) diet (0.3) throughout, or to one of two experimental groups eating a high P/S ratio diet (1.0) for one of two 6-week experimental periods. Changes in other components were avoided. 2. Twenty-four hour diet records showed substantial changes in the P/S ratio for experimental groups when on the high P/S ratio diet (0.3 to 1.0). 3. There were significant increases in relative concentrations of linoleic acid in plasma phospholipids when on the high P/S ratio diet. 4. There was no consistent effect of dietary P/S ratio elevation from 0.3 to 1.0 on group mean systolic and diastolic blood pressures. Adjustment of blood pressure changes for changes in electrolytes, other dietary components, plasma lipids, weight and other lifestyle variables did not alter this result. 5. It was concluded that the blood pressure lowering effect of a vegetarian diet reported previously was unlikely to have been due to changes in dietary P/S ratio.

scholarly journals BLOOD PRESSURE LOWERING EFFECT OF POLYHERBAL PREPARATION CONTAINING ALLIUM SATIVUM, BELERICAE FRUCTUS, CURCUMA AERUGINOSA, AND AMOMI FRUCTUS ON RAT MODEL OF HYPERTENSION

2019 ◽  
pp. 311-314 ◽  
Author(s):  
DWI ARIS AGUNG NUGRAHANINGSIH ◽  
SHOLIKHAH EN ◽  
MUSTOFA M ◽  
YULIANI FS ◽  
PURWONO S ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Rat Model ◽  
Allium Sativum ◽  
Negative Control ◽  
Control Group ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Lowering Effect ◽  
Treatment Dose ◽  
Pressure Lowering

Objective: The study aimed to investigate the blood pressure lowering effect of the polyherbal preparation contains Allium sativum, Belericae fructus, Curcuma aeruginosa, and Amomi fructus in the animal model of hypertension. Methods: Deoxycorticosterone acetate uninephrectomy salt rat model was used to develop hypertension model. Hypertensive rats were divided into five groups that were no treatment (negative control group [NEG]), hydrochlorothiazide treatment, polyherbal preparation 63 mg/kg treatment (DOSE 1), polyherbal preparation 126 mg/kg treatment (DOSE 2), and polyherbal preparation 252 mg/kg treatment (DOSE 3). The treatment was started after hypertension developed and given for 3 weeks. Results: The result showed that the mean of systolic blood pressure in DOSE 2 group was significantly lower compared with those on NEG group (145.86 mmHg vs. 174.71 mmHg, p<0.05). Conclusion: Our study provides evidence to support the use of the polyherbal preparation containing A. sativum, B. fructus, C. aeruginosa, and A. fructus for lowering blood pressure.

A randomized controlled trial of the effect on blood pressure of dietary non-meat protein versus meat protein in normotensive omnivores

1988 ◽  
Vol 74 (6) ◽  
pp. 665-672 ◽  
Author(s):  
Susan L. Prescott ◽  
David A. Jenner ◽  
Lawrence J. Beilin ◽  
Barrie M. Margetts ◽  
Robert Vandongen
Keyword(s):  
Blood Pressure ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Vegetarian Diet ◽  
Dietary Intakes ◽  
Blood Pressure Lowering ◽  
Meat Protein ◽  
Randomized Controlled ◽  
Pressure Lowering ◽  
Protein Components

1. A randomized, controlled trial was carried out to examine whether changes in type and amount of dietary protein were responsible for earlier observations of blood-pressure-lowering effects of lacto-ovo-vegetarian diets. 2. Sixty-four subjects were pair-matched for sex, age, weight and sitting systolic blood pressure, and were randomly allocated to receive one of two types of protein supplement: one containing proteins from meat, the other proteins from non-meat sources. The supplements were balanced in terms of other nutrients. Consumption of other meat, poultry or fish was prohibited. 3. Sitting and standing blood pressures, weight, dietary intakes and plasma and urinary electrolytes were measured at regular intervals during the 12 weeks of trial. Urinary 3-methylhistidine was used as a measure of compliance. 4. Fifty subjects completed the trial. There were no statistically significant blood pressure differences between groups either at baseline or at end-of-trial, neither were there any substantive differences in mean blood pressure changes between baseline and end-of-trial. 3-Methylhistidine excretion was significantly lower in subjects on the non-meat diet. 5. The results suggest that the protein components of the lacto-ovo-vegetarian diet are not responsible for the blood-pressure-lowering effects of that diet.

scholarly journals Blood pressure lowering effect of Pennisetum glaucum in rats

2015 ◽  
Vol 10 (3) ◽  
pp. 494
Author(s):  
Muhammad Naveed Mushtaq ◽  
Muhammad Shoaib Akhtar ◽  
Alamgeer .
Keyword(s):  
Blood Pressure ◽  
Methanolic Extract ◽  
Pennisetum Glaucum ◽  
Invasive Technique ◽  
Maximum Effect ◽  
Control Group ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Lowering Effect ◽  
Pressure Lowering

<p>The present study was carried out to evaluate the seeds of Pennisetum glaucum for its blood pressure lowering effect in rats. Aqueous-methanolic extract of P. glaucum seeds in 250, 500 and 1000 mg/kg doses was studied in normotensive, egg-feed diet and glucose-induced hypertensive rats using non-invasive technique. The extract significantly (p˂0.5 - p˂0.001) decreased blood pressure and heart rate with maximum effect at 1,000 mg/kg dose. The extract was found to prevent rise in blood pressure of egg and glucose fed rats as compared to control group in 21 days study. The extract was safe in mice up to dose of 4 g/kg and sub-chronic toxicity study showed that there was no significant alterations in blood chemistry of extract treated rats. It is conceivable, therefore, that aqueous-methanolic extract of P. glaucum seeds has exerted considerable antihypertensive activity which may be due to the presence of phytochemical constituents.</p><p> </p>

scholarly journals Randomised trial on effect of involving media reporters in salt reduction programme to increase media reports and the public’s knowledge, belief and behaviors on salt and health: Changzhi reporters trial

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0252989
Author(s):  
Zhifang Li ◽  
Xiangxian Feng ◽  
Tao Wu ◽  
Lijing Yan ◽  
Paul Elliott ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Mass Media ◽  
Controlled Trial ◽  
Randomised Trial ◽  
Shanxi Province ◽  
Control Group ◽  
Blood Pressure Lowering Effect ◽  
Salt Reduction ◽  
Salt Substitute ◽  
Media Reports

Objective To assess the effects of a novel mass media intervention in increasing media reports on salt and health by involving media reporters in a scientifically well designed salt reduction trial. Methods We recruited and trained 66 media reporters in Changzhi, Shanxi province, China to conduct a randomized controlled trial on blood pressure lowering effect of salt substitute in Dec, 2012 and Jan 2013 among their own relatives or friends (253 from 129 families in the salt substitute arm and 263 from 133 families in the control arm for two months). We shared trial results and other information on salt and health with the reporters within a month after the trial. We monitored all local newspapers for the number of relevant articles in 3 months before, 3 months during and 3 months after the intervention and at the 6th, 12th, 18th, 24th and 48th months after the intervention. Additionally, we conducted two independent surveys on knowledge, belief and behaviours of salt and health among local citizens before and after the intervention. Results As expected, systolic blood pressure was reduced significantly more in the salt substitute than the control group (-4.7±11.0 mmHg vs -2.6±10.3 mmHg, p<0.001) in the randomized trial. The monthly mean number of relevant articles increased from 0.7 before to 1.7 during (p = 0.263), and further to 6.0 after the intervention (p<0.001), and varied from 2 (p = 0.170) to 4 (p = 0.008) from the 6th to 48th month; the awareness of knowledge on salt and health among local citizens improved significantly after the intervention. Conclusions Media reporters’ participation in a well-designed salt reduction trial significantly increased the number of relevant media reports, and the effect was sustained for a prolonged period. Future mass media public health education programs should consider this innovative strategy for better and sustained impacts.

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