scholarly journals BLOOD PRESSURE LOWERING EFFECT OF POLYHERBAL PREPARATION CONTAINING ALLIUM SATIVUM, BELERICAE FRUCTUS, CURCUMA AERUGINOSA, AND AMOMI FRUCTUS ON RAT MODEL OF HYPERTENSION

2019 ◽  
pp. 311-314 ◽  
Author(s):  
DWI ARIS AGUNG NUGRAHANINGSIH ◽  
SHOLIKHAH EN ◽  
MUSTOFA M ◽  
YULIANI FS ◽  
PURWONO S ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Rat Model ◽  
Allium Sativum ◽  
Negative Control ◽  
Control Group ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Lowering Effect ◽  
Treatment Dose ◽  
Pressure Lowering

Objective: The study aimed to investigate the blood pressure lowering effect of the polyherbal preparation contains Allium sativum, Belericae fructus, Curcuma aeruginosa, and Amomi fructus in the animal model of hypertension. Methods: Deoxycorticosterone acetate uninephrectomy salt rat model was used to develop hypertension model. Hypertensive rats were divided into five groups that were no treatment (negative control group [NEG]), hydrochlorothiazide treatment, polyherbal preparation 63 mg/kg treatment (DOSE 1), polyherbal preparation 126 mg/kg treatment (DOSE 2), and polyherbal preparation 252 mg/kg treatment (DOSE 3). The treatment was started after hypertension developed and given for 3 weeks. Results: The result showed that the mean of systolic blood pressure in DOSE 2 group was significantly lower compared with those on NEG group (145.86 mmHg vs. 174.71 mmHg, p<0.05). Conclusion: Our study provides evidence to support the use of the polyherbal preparation containing A. sativum, B. fructus, C. aeruginosa, and A. fructus for lowering blood pressure.

scholarly journals Blood pressure lowering effect of Pennisetum glaucum in rats

2015 ◽  
Vol 10 (3) ◽  
pp. 494
Author(s):  
Muhammad Naveed Mushtaq ◽  
Muhammad Shoaib Akhtar ◽  
Alamgeer .
Keyword(s):  
Blood Pressure ◽  
Methanolic Extract ◽  
Pennisetum Glaucum ◽  
Invasive Technique ◽  
Maximum Effect ◽  
Control Group ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Lowering Effect ◽  
Pressure Lowering

<p>The present study was carried out to evaluate the seeds of Pennisetum glaucum for its blood pressure lowering effect in rats. Aqueous-methanolic extract of P. glaucum seeds in 250, 500 and 1000 mg/kg doses was studied in normotensive, egg-feed diet and glucose-induced hypertensive rats using non-invasive technique. The extract significantly (p˂0.5 - p˂0.001) decreased blood pressure and heart rate with maximum effect at 1,000 mg/kg dose. The extract was found to prevent rise in blood pressure of egg and glucose fed rats as compared to control group in 21 days study. The extract was safe in mice up to dose of 4 g/kg and sub-chronic toxicity study showed that there was no significant alterations in blood chemistry of extract treated rats. It is conceivable, therefore, that aqueous-methanolic extract of P. glaucum seeds has exerted considerable antihypertensive activity which may be due to the presence of phytochemical constituents.</p><p> </p>

scholarly journals Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kazuhisa Sugai ◽  
Tomoyoshi Tamura ◽  
Motoaki Sano ◽  
Shizuka Uemura ◽  
Masahiko Fujisawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Parasympathetic Nervous System ◽  
Pressure Control ◽  
Hydrogen Gas ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Night Time ◽  
Lowering Effect ◽  
Pressure Lowering

AbstractA recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H2) improves blood pressure control in end-stage kidney disease. Herein, we examined whether H2 has a salutary effect on hypertension in animal models. We subjected 5/6 nephrectomised rats to inhalation of either H2 (1.3% H2 + 21% O2 + 77.7% N2) or control (21% O2 + 79% N2) gas mixture for 1 h per day. H2 significantly suppressed increases in blood pressure after 5/6 nephrectomy. The anti-hypertensive effect of H2 was also confirmed in rats in a stable hypertensive state 3 weeks after nephrectomy. To examine the detailed effects of H2 on hypertension, we used an implanted telemetry system to continuously monitor blood pressure. H2 exerted an anti-hypertensive effect not only during daytime rest, but also during night-time activities. Spectral analysis of blood pressure variability revealed that H2 improved autonomic imbalance, namely by suppressing the overly active sympathetic nervous system and augmenting parasympathetic nervous system activity; these effects co-occurred with the blood pressure-lowering effect. In conclusion, 1-h daily exposure to H2 exerts an anti-hypertensive effect in an animal model of hypertension.

Blood pressure-lowering effect of dietary (−)-epicatechin administration in L-NAME-treated rats is associated with restored nitric oxide levels

2012 ◽  
Vol 53 (10) ◽  
pp. 1894-1902 ◽  
Author(s):  
Maria C. Litterio ◽  
Grayson Jaggers ◽  
Gulcin Sagdicoglu Celep ◽  
Ana M. Adamo ◽  
Maria A. Costa ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Lowering Effect ◽  
Pressure Lowering

[OP.2C.04] THE BLOOD PRESSURE LOWERING EFFECT ON NEW-ONSET ATRIAL FIBRILLATION

2016 ◽  
Vol 34 ◽  
pp. e22-e23
Author(s):  
G. Mourtzinis ◽  
L. Schiöler ◽  
K. Bengtsson Boström ◽  
T. Kahan ◽  
P. Hjerpe ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Blood Pressure ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Lowering Effect ◽  
Pressure Lowering ◽  
Onset Atrial Fibrillation ◽  
New Onset

scholarly journals Blood pressure-lowering effect of repeated Waon therapy in non-smokers with hypertension

Medicine ◽  
2021 ◽  
Vol 100 (23) ◽  
pp. e26266
Author(s):  
Kazuyuki Kominami ◽  
Etsuko Takahiza ◽  
Mineko Tabuchi ◽  
Masatoshi Akino
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Lowering Effect ◽  
Pressure Lowering
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