Use of plasma creatine kinase pharmacokinetics to estimate the amount of exercise-induced muscle damage in Beagles

2001 ◽  
Vol 62 (9) ◽  
pp. 1375-1380 ◽  
Author(s):  
Guillaume P. Chanoit ◽  
Herve P. Lefebvre ◽  
Karine Orcel ◽  
Valerie Laroute ◽  
Pierre-Louis Toutain ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Exercise Induced ◽  
Plasma Creatine Kinase

Plasma creatine kinase activity and exercise-induced muscle damage in older men

1991 ◽  
Vol 23 (9) ◽  
pp. 1028???1034 ◽  
Author(s):  
THOMAS G. MANFREDI ◽  
ROGER A. FIELDING ◽  
KEVIN P. O??REILLY ◽  
CAROL N. MEREDITH ◽  
HO YONG LEE ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Kinase Activity ◽  
Older Men ◽  
Creatine Kinase Activity ◽  
Exercise Induced ◽  
Plasma Creatine Kinase ◽  
Plasma Creatine Kinase Activity

The Effects of Leucine-Enriched Branched-Chain Amino Acid Supplementation on Recovery After High-Intensity Resistance Exercise

2019 ◽  
Vol 14 (8) ◽  
pp. 1081-1088 ◽  
Author(s):  
Adam D. Osmond ◽  
Dean J. Directo ◽  
Marcus L. Elam ◽  
Gabriela Juache ◽  
Vince C. Kreipke ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Resistance Exercise ◽  
Muscle Damage ◽  
Peak Power ◽  
Average Power ◽  
Amino Acid Supplementation ◽  
Performance Recovery ◽  
Branched Chain ◽  
Exercise Induced ◽  
Plasma Creatine Kinase

Context: Of the 3 branched-chain amino acids (BCAA), leucine has arguably received the most attribution for the role of BCAA supplementation in alleviating symptoms of exercise-induced muscle damage and facilitation of acute performance recovery. Purpose: To examine whether enrichment of a standard BCAA supplement with additional leucine or a standalone leucine (LEU) supplement differentially affects exercise-induced muscle damage and performance recovery compared with a standard BCAA supplement. Methods: A total of 22 recreationally active male and female subjects were recruited and assigned to consume a BCAA, leucine-enriched BCAA (LBCAA), or LEU supplement for 11 d. On the eighth day, subjects performed eccentric-based resistance exercise (ECRE). Lower-body mean average and peak power, plasma creatine kinase, soreness, and pain threshold were measured before and 24, 48, and 72 h after ECRE. Results: LEU showed decreased mean average power (P = .02) and mean peak power (P = .01) from baseline to 48 h post-ECRE, whereas LBCAA and BCAA only trended toward a reduction at 24 hours post-ECRE. At 48 h post-ECRE, BCAA showed greater recovery of mean peak power than LEU (P = .04). At 24 h post-ECRE, LEU demonstrated a greater increase in plasma creatine kinase from baseline than BCAA (P = .04). Area under the curve for creatine kinase was greater in LEU than BCAA (P = .02), whereas BCAA and LBCAA did not differ. Only LEU demonstrated increased soreness during rest and under muscular tension at 24 and 48 h post-ECRE (P < .05). Conclusions: LBCAA failed to afford any advantages over a standard BCAA supplement for postexercise muscle recovery, whereas a LEU supplement was comparatively ineffective.

scholarly journals Comparison of Pro-Regenerative Effects of Carbohydrates and Protein Administrated by Shake and Non-Macro-Nutrient Matched Food Items on the Skeletal Muscle after Acute Endurance Exercise

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 744 ◽  
Author(s):  
Eduard Isenmann ◽  
Franziska Blume ◽  
Daniel Bizjak ◽  
Vera Hundsdörfer ◽  
Sarah Pagano ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Muscle Damage ◽  
Serum Insulin ◽  
Serum Markers ◽  
Serum Creatine Kinase ◽  
Skeletal Muscle Regeneration ◽  
Skeletal Muscle Damage ◽  
Leg Strength ◽  
Exercise Induced

Physical performance and regeneration after exercise is enhanced by the ingestion of proteins and carbohydrates. These nutrients are generally consumed by athletes via whey protein and glucose-based shakes. In this study, effects of protein and carbohydrate on skeletal muscle regeneration, given either by shake or by a meal, were compared. 35 subjects performed a 10 km run. After exercise, they ingested nothing (control), a protein/glucose shake (shake) or a combination of white bread and sour milk cheese (food) in a randomized cross over design. Serum glucose (n = 35), serum insulin (n = 35), serum creatine kinase (n = 15) and myoglobin (n = 15), hematologic parameters, cortisol (n = 35), inflammation markers (n = 27) and leg strength (n = 15) as a functional marker were measured. Insulin secretion was significantly stimulated by shake and food. In contrast, only shake resulted in an increase of blood glucose. Food resulted in a decrease of pro, and stimulation of anti-inflammatory serum markers. The exercise induced skeletal muscle damage, indicated by serum creatine kinase and myoglobin, and exercise induced loss of leg strength was decreased by shake and food. Our data indicate that uptake of protein and carbohydrate by shake or food reduces exercise induced skeletal muscle damage and has pro-regenerative effects.

A Plasma Creatine Kinase MM Isoforms in the Study of Muscle Damage in Muscular Dystrophy

1987 ◽  
Vol 73 (s17) ◽  
pp. 50P-50P
Author(s):  
S Page ◽  
MJ Jackson ◽  
J Coakley ◽  
RHT Edwards
Keyword(s):  
Creatine Kinase ◽  
Muscular Dystrophy ◽  
Muscle Damage ◽  
Plasma Creatine Kinase

Children Are Less Susceptible to Exercise-Induced Muscle Damage than Adults: A Preliminary Investigation

1996 ◽  
Vol 8 (4) ◽  
pp. 361-367 ◽  
Author(s):  
José M.C. Soares ◽  
Paulo Mota ◽  
José A. Duarte ◽  
Hans J. Appell
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Muscle Pain ◽  
Bench Press ◽  
Preliminary Investigation ◽  
Serum Creatine Kinase ◽  
Subjective Perception ◽  
Adult Group ◽  
Intense Exercise ◽  
Exercise Induced

The aim of the present study was to investigate whether children showed similar signs of muscle overuse like adults after intense exercise. One child group (n = 10) and one adult group (n = 10) of males both had to perform five series of bench press exercises at an intensity of 80% of maximum strength until exhaustion. Maximum isometric strength, subjective perception of muscle pain, was measured before, immediately after, 48 hr, 72 hr, and 1 week after the exercise. Serum creatine kinase (CK) activity was measured before, 48 hr, 72 hr, and 1 week after the exercise. The adults showed all symptoms of muscle overuse: reduced strength, muscle pain, and elevated CK activities until 3 days after the exercise. In contrast, the children experienced only some light muscle pain, but neither showed reduced strength nor elevated CK activities. It is concluded that children’s muscles can easier withstand physical stress than adult muscles.

scholarly journals Do Antioxidant Vitamins Prevent Exercise-Induced Muscle Damage? A Systematic Review

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 372 ◽  
Author(s):  
María Martinez-Ferran ◽  
Fabian Sanchis-Gomar ◽  
Carl J. Lavie ◽  
Giuseppe Lippi ◽  
Helios Pareja-Galeano
Keyword(s):  
Systematic Review ◽  
Creatine Kinase ◽  
Muscle Damage ◽  
Web Of Science ◽  
Exercise Session ◽  
Post Exercise ◽  
High Doses ◽  
Exercise Induced ◽  
Cell Signaling Pathways

Free radicals produced during exercise play a role in modulating cell signaling pathways. High doses of antioxidants may hamper adaptations to exercise training. However, their benefits are unclear. This review aims to examine whether vitamin C (VitC) and/or vitamin E (VitE) supplementation (SUP) prevents exercise-induced muscle damage. The PubMed, Web of Science, Medline, CINAHL, and SPORTDiscus databases were searched, and 21 articles were included. Four studies examined the effects of acute VitC SUP given pre-exercise: in one study, lower CK levels post-exercise was observed; in three, no difference was recorded. In one study, acute VitE SUP reduced CK activity 1 h post-exercise in conditions of hypoxia. In three studies, chronic VitE SUP did not reduce CK activity after an exercise session. Chronic VitE SUP did not reduce creatine kinase (CK) concentrations after three strength training sessions, but it was effective after 6 days of endurance training in another study. Chronic SUP with VitC + E reduced CK activity post-exercise in two studies, but there was no such effect in four studies. Finally, three studies described the effects of chronic VitC + E SUP and long-term exercise, reporting dissimilar results. To conclude, although there is some evidence of a protective effect of VitC and/or VitE against exercise-induced muscle damage, the available data are not conclusive.

scholarly journals Repeated Bout Effect Was More Expressed in Young Adult Males Than in Elderly Males and Boys

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Giedrius Gorianovas ◽  
Albertas Skurvydas ◽  
Vytautas Streckis ◽  
Marius Brazaitis ◽  
Sigitas Kamandulis ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Muscle Soreness ◽  
Repeated Bout Effect ◽  
Adult Males ◽  
Elderly Males ◽  
Dependent Variables ◽  
Drop Jumps ◽  
Exercise Induced ◽  
Repeated Bout

This study investigated possible differences using the same stretch-shortening exercise (SSE) protocol on generally accepted monitoring markers (dependent variables: changes in creatine kinase, muscle soreness, and voluntary and electrically evoked torque) in males across three lifespan stages (childhood versus adulthood versus old age). The protocol consisted of 100 intermittent (30 s interval between jumps) drop jumps to determine the repeated bout effect (RBE) (first and second bouts performed at a 2-week interval). The results showed that indirect symptoms of exercise-induced muscle damage after SSE were more expressed in adult males than in boys and elderly males, suggesting that the muscles of boys and elderly males are more resistant to exercise-induced damage than those of adult males. RBE was more pronounced in adult males than in boys and elderly males, suggesting that the muscles of boys and elderly males are less adaptive to exercise-induced muscle damage than those of adult males.

scholarly journals Oral contraceptive pill use and the susceptibility to markers of exercise-induced muscle damage

2017 ◽  
Vol 117 (7) ◽  
pp. 1393-1402 ◽  
Author(s):  
K. M. Hicks ◽  
G. Onambélé-Pearson ◽  
K. Winwood ◽  
C. I. Morse
Keyword(s):  
Creatine Kinase ◽  
Oral Contraceptive ◽  
Muscle Damage ◽  
Vastus Lateralis ◽  
Oral Contraceptive Pill ◽  
Knee Extension ◽  
Patella Tendon ◽  
Contraceptive Pill ◽  
Exercise Induced ◽  
Tendon Properties

Abstract Purpose Firstly, to establish whether oral contraceptive pill (OCP) users are more susceptible to muscle damage compared to non-users, and secondly, to establish whether differences can be attributed to differences in patella tendon properties. Methods Nine female OCP users and 9 female non-users participated in the investigation. Combining dynamometry, electromyography and ultrasonography, patella tendon properties and vastus lateralis architectural properties were measured pre and during the first of 6 sets of 12 maximal voluntary eccentric knee extensions. Serum oestrogen levels were measured on the 7th day of the pill cycle and the 14th day of menstrual cycle in OCP users and non-users, respectively. Maximal voluntary isometric knee extension torque loss, creatine kinase and muscle soreness were measured 48 h pre-damage, post-damage, and 48, 96 and 168 h post-damage. Results Oestrogen levels were significantly lower in OCP users compared to non-users (209 ± 115 and 433 ± 147 pg/ml, respectively, p = 0.004). Proposed determinants of muscle damage, patella tendon stiffness and maximal eccentric torque did not differ between OCP users and non-users. The change in creatine kinase from pre to peak was significantly higher in OCP users compared to non-users (962 ± 968 and 386 ± 474 Ul, respectively, p = 0.016). There were no other differences in markers of muscle damage. Conclusion Although our findings suggest that, when compared to non-users, the OCP may augment the creatine kinase response following eccentric exercise, it does not increase the susceptibility to any other markers of muscle damage.

scholarly journals Exercise-Induced Muscle Damage and Cardiac Stress During a Marathon Could be Associated with Dietary Intake During the Week Before the Race

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 316 ◽  
Author(s):  
Juan Mielgo-Ayuso ◽  
Julio Calleja-González ◽  
Ignacio Refoyo ◽  
Patxi León-Guereño ◽  
Alfredo Cordova ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Food Intake ◽  
Dietary Intake ◽  
Olive Oil ◽  
Muscle Damage ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Negatively Associated ◽  
Cardiac Stress ◽  
Exercise Induced

Adequate food intake is important prior to endurance running competitions to facilitate adequate exercise intensity. However, no investigations have examined whether dietary intake could prevent exercise-induced muscle damage (EIMD) and cardiac stress (EICS). Thus, this study’s objective was to determine the associations between EIMD, EICS and endurance athlete diets one week before a marathon race. Sixty-nine male runners participated in this study. Food intake during the week prior to the race was collected through a seven-day weighed food record. Dietary intake on race day was also recorded. At the end of the marathon, blood samples were drawn to determine serum creatine kinase (CK) and myoglobin, and muscle–brain isoform creatine kinase (CK-MB), prohormone of brain natriuretic peptide (NT-proBNP), cardiac troponin I (TNI), and cardiac troponin T (TNT) concentration as markers of EIMD and EICS, respectively. To determine the association between these variables, a stepwise regression analysis was carried out. The dependent variable was defined as EIMD or EICS and the independent variables were defined as the number of servings within each different food group. Results showed that the intake of meat during the previous week was positively associated with post-race CK (Standardized Coefficients (β) = 0.643; p < 0.01) and myoglobin (β = 0.698; p < 0.001). Vegetables were negatively associated the concentration of post-race CK (β = −0.482; p = 0.002). Butter and fatty meat were positively associated with NT-proBNP (β = 0.796; p < 0.001) and TNI (β = 0.396; p < 0.001) post-marathon values. However, fish intake was negatively associated with CK (β = −0.272; p = 0.042), TNI (β = −0.593; p < 0.001) and TNT (β = −0.640; p = 0.002) post-marathon concentration. Olive oil was negatively associated with TNI (β = −0.536; p < 0.001) and TNT (β = −0.415; p = 0.021) values. In conclusion, the consumption of meat, butter, and fatty meat might be associated with higher levels of EIMD and EICS. On the other hand, fish, vegetables, and olive oil might have a protective role against EIMD and EICS. The selection of an adequate diet before a marathon might help to reduce some of the acute burdens associated with marathon races.

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