Urinary excretion of digoxin-like immunoreactive factor and arginine-vasopressin in hyper- and hypo-thyroid rats

1991 ◽  
Vol 81 (s25) ◽  
pp. 471-476 ◽  
Author(s):  
Felix Vargas ◽  
Maria J. Baz ◽  
Juan de D. Luna ◽  
Jesus Andrade ◽  
Esteban Jodar ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Hypertonic Saline ◽  
Arginine Vasopressin ◽  
Water Deprivation ◽  
Water Metabolism ◽  
Rat Urine ◽  
Urinary Levels ◽  
Vasopressin Secretion ◽  
Response To Water ◽  
Osmotic Stimuli

1. Urinary excretion of digoxin-like immunoreactive factor and arginine-vasopressin and other parameters related to salt and water metabolism were studied in hyper- and hypo-thyroid rats after different tests. 2. Urinary excretion of arginine-vasopressin was increased in hyperthyroid and reduced in hypothyroid rats with respect to controls, in response to water deprivation or a hypertonic saline load. 3. Control and hypothyroid rats showed the highest urinary excretion of digoxin-like immunoreactive factor after a hypertonic saline load. However, hyperthyroid rats had the highest urinary levels of digoxin-like immunoreactive factor under normal conditions. 4. From these results it is suggested that: (a) hyper- and hypo-thyroid rats exhibit hyper- and hypo-responsiveness of arginine-vasopressin secretion to osmotic stimuli, respectively; (b) an unidentified digoxin-like immunoreactive factor measured in unextracted rat urine may be related to diuresis and natriuresis in control and hypothyroid rats; however, dissociation between this factor and natriuresis is observed in hyperthyroid rats.

Vasopressin, but not oxytocin, is released in response to water deprivation in conscious goats

1986 ◽  
Vol 110 (2) ◽  
pp. 335-340 ◽  
Author(s):  
S. N. Thornton ◽  
G. Leng ◽  
R. J. Bicknell ◽  
C. Chapman ◽  
T. Purdew
Keyword(s):  
Differential Effect ◽  
Water Deprivation ◽  
Sodium Concentration ◽  
Plasma Samples ◽  
Hormonal Response ◽  
Neurohypophysial Hormones ◽  
Regular Manner ◽  
Response To Water ◽  
Osmotic Stimuli

ABSTRACT Plasma samples obtained at 4-h intervals from goats for at least 24 h before and then during 24 h of deprivation of water were analysed by radioimmunoassay for vasopressin and oxytocin concentrations. The samples were also analysed for osmolality and sodium concentration. The differential effect of night/day versus day/night deprivation was also studied. During the two periods before the two deprivations osmolality varied in a regular manner, with low values occurring at 08.00 h. Sodium concentration followed osmolality, whereas vasopressin did not vary during the period before deprivation. During deprivation vasopressin increased along with osmolality and sodium concentration, with the beginning of the increase occurring after the morning feed. Oxytocin levels did not increase during the period of deprivation. These results do not support the hypothesis of general release of neurohypophysial hormones in response to osmotic stimuli but instead indicate there are species variations with respect to hormonal response to water deprivation. J. Endocr. (1986) 110, 335–340

Regulation of vasopressin secretion in a patient with chronic hypernatraemia

1985 ◽  
Vol 110 (3) ◽  
pp. 346-351 ◽  
Author(s):  
Simon Smitz ◽  
Jean-Jacques Legros
Keyword(s):  
Hypertonic Saline ◽  
Arginine Vasopressin ◽  
Plasma Osmolality ◽  
Concomitant Increase ◽  
Specific Radioimmunoassay ◽  
Vasopressin Secretion ◽  
Plasma Arginine ◽  
The Brain ◽  
Unrestricted Diet ◽  
Hypertonic Saline Infusion

Abstract. A patient with the chronic hypernatraemia syndrome is described. Using a sensitive and specific radioimmunoassay, the plasma arginine-vasopressin (AVP) level was measured under various conditions. With an unrestricted diet, the plasma AVP level was inappropriately low for the degree of plasma hyperosmolality (0.9 pmol/l and 302 mOsm/kg, respectively). After chronic water loading, plasma osmolality was 271 mOsm/kg, plasma AVP level 1.5 pmol/l, and the urine remained hypertonic with respect to the plasma. During hypertonic saline infusion, plasma osmolality increased from 271 to 294 mOsm/kg without a concomitant increase in the plasma AVP concentration. After sc injection of apomorphine and after haemodynamic stimulation, the plasma AVP concentration increased from 0.8 to 36 pmol/l and from 1.2 to 6.3 pmol/I, respectively. These data demonstrate a selective deficiency in the osmoregulation of the AVP secretion. The observed neuroendocrine abnormalities may be linked to a congenital malformation of the brain.

Satiety and inhibition of vasopressin secretion after drinking in dehydrated dogs

1981 ◽  
Vol 240 (4) ◽  
pp. E394-E401 ◽  
Author(s):  
T. N. Thrasher ◽  
J. F. Nistal-Herrera ◽  
L. C. Keil ◽  
D. J. Ramsay
Keyword(s):  
Arginine Vasopressin ◽  
Water Deprivation ◽  
Extracellular Fluid ◽  
Plasma Osmolality ◽  
Rapid Decline ◽  
Vasopressin Secretion

The roles of oropharyngeal and gastric factors in satiation and arginine vasopressin (AVP) secretion were examined in water-deprived dogs. Dogs were prepared with chronic gastric fistulas and received six treatments after 24 h of water deprivation: rehydration with H2O or extracellular fluid (ECF) with the fistula closed; rehydration with H2O or ECF with the fistula open; gastric administration of H2O or ECF via the fistula. Drinking occurred immediately after presentation and was always completed by 6 min. At the end of the 60-min period of observation, water was offered in order to assess the degree of satiety. No differences were observed between the volumes of H2O or ECF consumed. However, only absorption of the water drunk produced complete satiety assessed 60 min later. Drinking H2O caused a fall in plasma AVP 6 min before a detectable decline in osmolality and reached water-replete levels by 15 min after drinking. Drinking H2O or ECF plus removal via the fistula and drinking ECF also brought about a rapid decline in plasma AVP without any change in plasma osmolality. Gastric administration of H2O caused a fall in plasma AVP that coincided with the fall in osmolality, and gastric administration of ECF had no effect on plasma AVP. We conclude that oropharyngeal factors account for temporary satiety and the rapid inhibition of vasopressin secretion.

Natriuresis induced by arginine vasopressin infusion in sheep

1985 ◽  
Vol 249 (6) ◽  
pp. F799-F805 ◽  
Author(s):  
R. G. Park ◽  
M. Congiu ◽  
D. A. Denton ◽  
M. J. McKinley
Keyword(s):  
Arginine Vasopressin ◽  
Water Deprivation ◽  
Essential Role ◽  
Plasma Concentrations ◽  
Free Access ◽  
Daily Output ◽  
Vasopressin Infusion ◽  
Water Infusion ◽  
Access To Water ◽  
Response To Water

The aim of this study was to investigate whether arginine vasopressin (AVP) is natriuretic in sheep at plasma concentrations comparable to those induced by water deprivation. AVP was infused intravenously at 0.1, 0.2, and 0.5 microgram/h for 24-48 h in sheep allowed free access to water. Infusion of AVP at 0.1 microgram/h did not alter renal Na output, whereas infusion of AVP at both 0.2 and 0.5 microgram/h significantly increased daily output of Na in urine. Significant natriuresis did not occur until 3.5 h after the start of AVP infusion at 0.2 microgram/h. Plasma AVP levels induced by these infusions were 9.8 +/- 1.6 (0.1 microgram/h AVP), 21.9 +/- 7.7 (0.2 microgram/h AVP), and 32.5 +/- 9.0 pg/ml (0.5 microgram/h AVP) after 24 h. These concentrations are within the range found in sheep deprived of water for 3 days. Hypophysectomy abolished increases in plasma AVP concentration but not natriuresis in response to water deprivation. This suggests that increased plasma AVP concentration does not play an essential role in the mechanisms subserving dehydration-induced natriuresis.

Role of renal nerves in regulation of vasopressin secretion and blood pressure in conscious rabbits

1990 ◽  
Vol 258 (4) ◽  
pp. F821-F830 ◽  
Author(s):  
S. Matsukawa ◽  
L. C. Keil ◽  
I. A. Reid
Keyword(s):  
Blood Pressure ◽  
Hypertonic Saline ◽  
Water Deprivation ◽  
Renal Denervation ◽  
Saline Infusion ◽  
Renal Nerves ◽  
Vasopressin Secretion ◽  
The Relationship ◽  
Nitroprusside Infusion ◽  
Hypertonic Saline Infusion

The observation that electrical stimulation of the renal nerves increases vasopressin secretion raises the possibility that the renal nerves may participate in the control of vasopressin secretion. In the present investigation, the effects of renal denervation on the vasopressin response to two reflex stimuli (nitroprusside infusion and hemorrhage) and two osmotic stimuli (hypertonic saline infusion and water deprivation) were studied in conscious, chronically prepared rabbits. Nitroprusside infusion in 13 intact and 14 denervated rabbits caused similar decreases in mean arterial pressure (MAP) and the increase in plasma arginine vasopressin concentration (PAVP) in intact (2.6 +/- 0.3 to 5.8 +/- 0.9 pg/ml, P less than 0.01) and denervated (2.8 +/- 0.3 to 5.7 +/- 1.3 pg/ml, P less than 0.01) rabbits was not significantly different. Hemorrhage (20 ml/kg) in 15 intact and 14 denervated rabbits caused similar decreases in MAP. Again, the increase in PAVP from 2.7 +/- 0.3 to 159.0 +/- 37.1 pg/ml (P less than 0.01) in intact and from 5.0 +/- 1.7 to 115.4 +/- 45.6 pg/ml (P less than 0.01) in denervated rabbits was not significantly different, nor was the relationship between PAVP and MAP in the two groups. In seven intact rabbits, hypertonic saline infusion increased PAVP from 4.0 +/- 0.9 to 10.9 +/- 2.8 pg/ml (P less than 0.05). The change in six denervated rabbits was not significantly different, nor was the relationship between PAVP and plasma osmolality. During water deprivation (24 h) in six intact rabbits, PAVP increased from 4.0 +/- 0.7 to 6.9 +/- 0.6 pg/ml (P less than 0.05). Again, the increase in PAVP in six denervated rabbits was not significantly different from that in the intact rabbits. The change in MAP during water deprivation in the two groups was also not significantly different. Renal cortical norepinephrine concentration in denervated kidneys was less than 10 ng/g wet wt. These results indicate that, in conscious rabbits, renal denervation does not impair the osmotic or reflex regulation of vasopressin secretion, nor does it interfere with blood pressure regulation during hypovolemia or hypotension.

Abnormal arginine-vasopressin secretion and water metabolism in patients with postviral fatigue syndrome

2009 ◽  
Vol 87 (3) ◽  
pp. 234-238 ◽  
Author(s):  
A. M. O. Bakheit ◽  
P. O. Behan ◽  
W. S. Watson ◽  
J. J. Morton
Keyword(s):  
Arginine Vasopressin ◽  
Water Metabolism ◽  
Fatigue Syndrome ◽  
Vasopressin Secretion

Mechanism of drinking-induced inhibition of vasopressin secretion in dehydrated dogs

1991 ◽  
Vol 261 (5) ◽  
pp. R1226-R1233 ◽  
Author(s):  
B. H. Appelgren ◽  
T. N. Thrasher ◽  
L. C. Keil ◽  
D. J. Ramsay
Keyword(s):  
Arginine Vasopressin ◽  
Water Deprivation ◽  
Control Experiment ◽  
Control Period ◽  
Easy Access ◽  
Inhibitory Input ◽  
Inhibitory Mechanism ◽  
Blood Samples ◽  
Time Control ◽  
Vasopressin Secretion

Ingestion of water stimulates a powerful inhibitory input to secretion of arginine vasopressin (AVP) in many species. A previous study in dogs has suggested that the stimulus arises from activation of oropharyngeal receptors, but the nature of the stimulus is unknown. The objectives of this study were to determine if the taste, osmolality, or temperature of the solution ingested constituted an important element in the inhibitory mechanism and if these same attributes affected the volume ingested in response to 24 h of water deprivation in conscious dogs. Experiments consisted of a control period, a 6-min period of access to fluid, and a 60-min period after drinking, with blood samples taken frequently to assess changes in plasma AVP. Dogs were placed in a sling that allowed them to stand or lie supported with easy access to a bowl. The solutions were water at 20 and 38 degrees C; 0.9% NaCl at 20 and 38 degrees C; 1.8 and 2.7% NaCl at 20 degrees C; 5% glucose and mannitol and 10% mannitol at 20 degrees C; and liquified food at 20 degrees C. In the time-control experiment dogs were allowed to see but not drink water for 6 min.(ABSTRACT TRUNCATED AT 250 WORDS)

Inappropriate vasopressin secretion in two dogs

1988 ◽  
Vol 117 (1) ◽  
pp. 59-64 ◽  
Author(s):  
A. Rijnberk ◽  
W. J. Biewenga ◽  
J. A. Mol
Keyword(s):  
Hypertonic Saline ◽  
Arginine Vasopressin ◽  
Plasma Osmolality ◽  
High Plasma ◽  
The Other ◽  
Normal Response ◽  
Vasopressin Secretion ◽  
Low Threshold ◽  
Normal Sensitivity ◽  
Hypertonic Saline Infusion

Abstract. Two dogs with hyponatremia due to inappropriate arginine vasopressin (AVP) secretion are described. Threshold and sensitivity of AVP secretion were investigated by increasing plasma osmolality with hypertonic saline infusion. In one dog, osmoregulation of AVP secretion occurred at normal sensitivity but at a low threshold. The other dog had a relatively high plasma AVP concentration under (resting) hypotonic conditions with an otherwise normal response to increasing plasma tonicity. In the absence of evidence for associated disease, it is suggested that both dogs have an idiopathic form of the syndrome of inappropriate AVP secretion.

Norepinephrine regulates arginine vasopressin secretion in hypothalamic paraventricular nucleus relating with pain modulation

Neuropeptides ◽  
2009 ◽  
Vol 43 (4) ◽  
pp. 259-265 ◽  
Author(s):  
Jun Yang ◽  
Hui-Feng Yuan ◽  
Wen-Yan Liu ◽  
Xiao-Xia Zhang ◽  
Jian-Peng Feng ◽  
...  
Keyword(s):  
Paraventricular Nucleus ◽  
Arginine Vasopressin ◽  
Pain Modulation ◽  
Hypothalamic Paraventricular Nucleus ◽  
Vasopressin Secretion

scholarly journals Water Metabolism in Preterm Infants during the first Week of Life and its Regulation by Arginine-Vasopressin(AVP)

1986 ◽  
Vol 20 (11) ◽  
pp. 1181-1181
Author(s):  
H Stegner ◽  
R Henkel ◽  
J C Commentz ◽  
H H Hellwege ◽  
R P Willig
Keyword(s):  
Preterm Infants ◽  
Arginine Vasopressin ◽  
Water Metabolism
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